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Gene: WDR5 |
Gene summary for WDR5 |
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Gene information | Species | Human | Gene symbol | WDR5 | Gene ID | 11091 |
Gene name | WD repeat domain 5 | |
Gene Alias | BIG-3 | |
Cytomap | 9q34.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P61964 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11091 | WDR5 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.89e-03 | 1.86e-01 | -0.1954 |
11091 | WDR5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.06e-05 | 3.75e-01 | -0.059 |
11091 | WDR5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.91e-03 | 3.19e-01 | -0.0179 |
11091 | WDR5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.09e-06 | 3.44e-01 | 0.096 |
11091 | WDR5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.22e-03 | 2.23e-01 | 0.0674 |
11091 | WDR5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.11e-04 | 3.35e-01 | 0.294 |
11091 | WDR5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.51e-02 | 7.47e-01 | 0.3487 |
11091 | WDR5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.05e-09 | 5.25e-01 | 0.281 |
11091 | WDR5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.29e-18 | 7.05e-01 | 0.3859 |
11091 | WDR5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.89e-07 | 3.73e-01 | 0.3005 |
11091 | WDR5 | A015-C-203 | Human | Colorectum | FAP | 3.29e-02 | -7.49e-02 | -0.1294 |
11091 | WDR5 | A002-C-116 | Human | Colorectum | FAP | 2.00e-05 | -1.43e-01 | -0.0452 |
11091 | WDR5 | LZE4T | Human | Esophagus | ESCC | 1.35e-02 | 6.12e-02 | 0.0811 |
11091 | WDR5 | LZE20T | Human | Esophagus | ESCC | 2.89e-04 | 1.70e-01 | 0.0662 |
11091 | WDR5 | LZE24T | Human | Esophagus | ESCC | 1.17e-10 | 3.24e-01 | 0.0596 |
11091 | WDR5 | LZE21T | Human | Esophagus | ESCC | 2.34e-03 | 3.59e-01 | 0.0655 |
11091 | WDR5 | P1T-E | Human | Esophagus | ESCC | 5.88e-04 | 3.33e-01 | 0.0875 |
11091 | WDR5 | P2T-E | Human | Esophagus | ESCC | 1.51e-50 | 9.32e-01 | 0.1177 |
11091 | WDR5 | P4T-E | Human | Esophagus | ESCC | 3.19e-28 | 6.97e-01 | 0.1323 |
11091 | WDR5 | P5T-E | Human | Esophagus | ESCC | 1.57e-30 | 6.36e-01 | 0.1327 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00059963 | Colorectum | FAP | monosaccharide metabolic process | 59/2622 | 257/18723 | 6.79e-05 | 1.28e-03 | 59 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:0010675 | Colorectum | FAP | regulation of cellular carbohydrate metabolic process | 35/2622 | 146/18723 | 8.41e-04 | 8.72e-03 | 35 |
GO:00620131 | Colorectum | FAP | positive regulation of small molecule metabolic process | 34/2622 | 143/18723 | 1.15e-03 | 1.10e-02 | 34 |
GO:0045913 | Colorectum | FAP | positive regulation of carbohydrate metabolic process | 20/2622 | 75/18723 | 2.80e-03 | 2.15e-02 | 20 |
GO:0006479 | Colorectum | FAP | protein methylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0008213 | Colorectum | FAP | protein alkylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0034968 | Colorectum | FAP | histone lysine methylation | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:0016571 | Colorectum | FAP | histone methylation | 31/2622 | 141/18723 | 6.47e-03 | 4.03e-02 | 31 |
GO:0010906 | Colorectum | FAP | regulation of glucose metabolic process | 27/2622 | 119/18723 | 6.87e-03 | 4.22e-02 | 27 |
GO:007149626 | Esophagus | HGIN | cellular response to external stimulus | 71/2587 | 320/18723 | 2.77e-05 | 7.19e-04 | 71 |
GO:003166820 | Esophagus | HGIN | cellular response to extracellular stimulus | 56/2587 | 246/18723 | 9.05e-05 | 1.97e-03 | 56 |
GO:003166920 | Esophagus | HGIN | cellular response to nutrient levels | 47/2587 | 215/18723 | 8.20e-04 | 1.07e-02 | 47 |
GO:003166726 | Esophagus | HGIN | response to nutrient levels | 89/2587 | 474/18723 | 1.41e-03 | 1.64e-02 | 89 |
GO:000926719 | Esophagus | HGIN | cellular response to starvation | 34/2587 | 156/18723 | 4.21e-03 | 3.77e-02 | 34 |
GO:004259418 | Esophagus | HGIN | response to starvation | 41/2587 | 197/18723 | 4.34e-03 | 3.84e-02 | 41 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR5 | SNV | Missense_Mutation | rs746477625 | c.949N>A | p.Ala317Thr | p.A317T | P61964 | protein_coding | deleterious(0.03) | possibly_damaging(0.554) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR5 | SNV | Missense_Mutation | novel | c.906N>G | p.Asp302Glu | p.D302E | P61964 | protein_coding | deleterious(0.04) | benign(0.058) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR5 | SNV | Missense_Mutation | novel | c.221N>T | p.Ala74Val | p.A74V | P61964 | protein_coding | tolerated(0.25) | benign(0.005) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WDR5 | SNV | Missense_Mutation | c.689N>C | p.Leu230Pro | p.L230P | P61964 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR5 | SNV | Missense_Mutation | c.874N>C | p.Glu292Gln | p.E292Q | P61964 | protein_coding | tolerated(0.11) | benign(0.267) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
WDR5 | deletion | Frame_Shift_Del | c.642delN | p.Val217CysfsTer4 | p.V217Cfs*4 | P61964 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
WDR5 | insertion | Frame_Shift_Ins | rs780890680 | c.648dupC | p.Val217ArgfsTer42 | p.V217Rfs*42 | P61964 | protein_coding | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | ||
WDR5 | deletion | Frame_Shift_Del | c.642delN | p.Val217CysfsTer4 | p.V217Cfs*4 | P61964 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WDR5 | deletion | Frame_Shift_Del | c.648delC | p.Val217CysfsTer4 | p.V217Cfs*4 | P61964 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WDR5 | deletion | Frame_Shift_Del | c.642delN | p.Val217CysfsTer4 | p.V217Cfs*4 | P61964 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11091 | WDR5 | DRUGGABLE GENOME, TUMOR SUPPRESSOR | antagonist | 249565911 |
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