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Gene: WBP2 |
Gene summary for WBP2 |
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Gene information | Species | Human | Gene symbol | WBP2 | Gene ID | 23558 |
Gene name | WW domain binding protein 2 | |
Gene Alias | DFNB107 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q969T9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23558 | WBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.04e-11 | 5.44e-01 | -0.1808 |
23558 | WBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.27e-09 | 3.33e-01 | -0.1954 |
23558 | WBP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.39e-09 | 1.02e+00 | -0.2602 |
23558 | WBP2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.54e-05 | 5.14e-01 | -0.2196 |
23558 | WBP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.71e-09 | 3.14e-01 | -0.1464 |
23558 | WBP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.76e-03 | 1.96e-01 | -0.1001 |
23558 | WBP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.49e-10 | 4.43e-01 | -0.059 |
23558 | WBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.44e-04 | 1.84e-01 | 0.096 |
23558 | WBP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.68e-04 | 2.31e-01 | 0.0338 |
23558 | WBP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.26e-06 | 1.80e-01 | 0.0674 |
23558 | WBP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.33e-03 | 2.00e-01 | 0.294 |
23558 | WBP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.21e-04 | 2.07e-01 | 0.281 |
23558 | WBP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.91e-17 | 4.00e-01 | 0.3859 |
23558 | WBP2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.71e-09 | 2.90e-01 | 0.3005 |
23558 | WBP2 | LZE4T | Human | Esophagus | ESCC | 2.54e-20 | 3.94e-01 | 0.0811 |
23558 | WBP2 | LZE7T | Human | Esophagus | ESCC | 2.35e-10 | 4.88e-01 | 0.0667 |
23558 | WBP2 | LZE8T | Human | Esophagus | ESCC | 6.31e-09 | 1.88e-01 | 0.067 |
23558 | WBP2 | LZE20T | Human | Esophagus | ESCC | 1.00e-06 | 4.03e-01 | 0.0662 |
23558 | WBP2 | LZE22D1 | Human | Esophagus | HGIN | 7.46e-03 | 1.11e-01 | 0.0595 |
23558 | WBP2 | LZE22T | Human | Esophagus | ESCC | 3.52e-06 | 4.97e-01 | 0.068 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00305182 | Colorectum | MSS | intracellular steroid hormone receptor signaling pathway | 44/3467 | 116/18723 | 6.95e-07 | 2.49e-05 | 44 |
GO:00097552 | Colorectum | MSS | hormone-mediated signaling pathway | 63/3467 | 190/18723 | 9.26e-07 | 3.23e-05 | 63 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:0030520 | Colorectum | MSS | intracellular estrogen receptor signaling pathway | 21/3467 | 54/18723 | 3.68e-04 | 4.66e-03 | 21 |
GO:0033143 | Colorectum | MSS | regulation of intracellular steroid hormone receptor signaling pathway | 26/3467 | 74/18723 | 5.15e-04 | 5.97e-03 | 26 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:0032570 | Colorectum | MSS | response to progesterone | 14/3467 | 37/18723 | 4.55e-03 | 3.20e-02 | 14 |
GO:00310562 | Colorectum | MSS | regulation of histone modification | 41/3467 | 152/18723 | 6.41e-03 | 4.27e-02 | 41 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:003052220 | Esophagus | HGIN | intracellular receptor signaling pathway | 62/2587 | 265/18723 | 1.63e-05 | 4.50e-04 | 62 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:004854527 | Esophagus | HGIN | response to steroid hormone | 73/2587 | 339/18723 | 6.06e-05 | 1.40e-03 | 73 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
GO:00310568 | Esophagus | HGIN | regulation of histone modification | 36/2587 | 152/18723 | 7.06e-04 | 9.52e-03 | 36 |
GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
GO:00325708 | Esophagus | HGIN | response to progesterone | 13/2587 | 37/18723 | 9.03e-04 | 1.15e-02 | 13 |
GO:003051818 | Esophagus | HGIN | intracellular steroid hormone receptor signaling pathway | 29/2587 | 116/18723 | 9.06e-04 | 1.15e-02 | 29 |
GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
GO:007138320 | Esophagus | HGIN | cellular response to steroid hormone stimulus | 44/2587 | 204/18723 | 1.56e-03 | 1.79e-02 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WBP2 | SNV | Missense_Mutation | c.332N>G | p.Lys111Arg | p.K111R | Q969T9 | protein_coding | deleterious(0.02) | probably_damaging(0.933) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
WBP2 | SNV | Missense_Mutation | rs563500410 | c.299C>T | p.Ala100Val | p.A100V | Q969T9 | protein_coding | deleterious(0.01) | benign(0.37) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WBP2 | SNV | Missense_Mutation | novel | c.514N>C | p.Tyr172His | p.Y172H | Q969T9 | protein_coding | tolerated(0.14) | possibly_damaging(0.597) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WBP2 | SNV | Missense_Mutation | rs367581512 | c.682N>A | p.Ala228Thr | p.A228T | Q969T9 | protein_coding | tolerated(0.1) | probably_damaging(0.995) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WBP2 | SNV | Missense_Mutation | c.500N>A | p.Pro167His | p.P167H | Q969T9 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
WBP2 | SNV | Missense_Mutation | rs771265316 | c.256N>A | p.Val86Ile | p.V86I | Q969T9 | protein_coding | tolerated(0.05) | probably_damaging(0.979) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WBP2 | SNV | Missense_Mutation | rs760988068 | c.293N>T | p.Ala98Val | p.A98V | Q969T9 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WBP2 | SNV | Missense_Mutation | rs563500410 | c.299N>T | p.Ala100Val | p.A100V | Q969T9 | protein_coding | deleterious(0.01) | benign(0.37) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WBP2 | SNV | Missense_Mutation | novel | c.389N>T | p.Ala130Val | p.A130V | Q969T9 | protein_coding | deleterious(0) | possibly_damaging(0.61) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
WBP2 | SNV | Missense_Mutation | novel | c.175N>G | p.Phe59Val | p.F59V | Q969T9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DI-A1NO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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