|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: WBP1 |
Gene summary for WBP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | WBP1 | Gene ID | 23559 |
| Gene name | WW domain binding protein 1 | |
| Gene Alias | WBP-1 | |
| Cytomap | 2p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96G27 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23559 | WBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-08 | 1.93e-01 | 0.0155 |
| 23559 | WBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.65e-07 | 2.41e-01 | -0.1808 |
| 23559 | WBP1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
| 23559 | WBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.76e-01 | -0.0811 |
| 23559 | WBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.70e-01 | -0.1088 |
| 23559 | WBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.42e-16 | 3.03e-01 | -0.1954 |
| 23559 | WBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 4.03e-01 | -0.2602 |
| 23559 | WBP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.03e-08 | 2.57e-01 | -0.1207 |
| 23559 | WBP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.35e-06 | 2.45e-01 | -0.1526 |
| 23559 | WBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.35e-15 | 2.94e-01 | -0.1464 |
| 23559 | WBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.47e-08 | 1.81e-01 | -0.1001 |
| 23559 | WBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.26e-01 | -0.059 |
| 23559 | WBP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.15e-01 | -0.2061 |
| 23559 | WBP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.52e-01 | -0.1462 |
| 23559 | WBP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-05 | 2.30e-01 | -0.0842 |
| 23559 | WBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.77e-13 | 3.09e-01 | 0.096 |
| 23559 | WBP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.36e-01 | 0.0446 |
| 23559 | WBP1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.03e-05 | 4.04e-01 | 0.0451 |
| 23559 | WBP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.49e-06 | 3.07e-01 | 0.0528 |
| 23559 | WBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-07 | 3.59e-01 | 0.0131 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
| GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
| GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
| GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
| GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
| GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
| GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
| GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
| GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
| GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
| GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
| GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
| GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
| GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
| GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
| GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| WBP1 | SNV | Missense_Mutation | novel | c.249N>T | p.Arg83Ser | p.R83S | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
| WBP1 | SNV | Missense_Mutation | novel | c.274N>C | p.Glu92Gln | p.E92Q | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| WBP1 | SNV | Missense_Mutation | c.31N>C | p.Glu11Gln | p.E11Q | Q96G27 | protein_coding | deleterious_low_confidence(0.01) | benign(0.171) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| WBP1 | insertion | Frame_Shift_Ins | rs547055147 | c.551dupC | p.His185SerfsTer5 | p.H185Sfs*5 | Q96G27 | protein_coding | TCGA-C5-A7CM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
| WBP1 | SNV | Missense_Mutation | c.458N>A | p.Ser153Asn | p.S153N | Q96G27 | protein_coding | deleterious(0.04) | benign(0) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| WBP1 | SNV | Missense_Mutation | novel | c.278N>A | p.Ile93Asn | p.I93N | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
| WBP1 | deletion | Frame_Shift_Del | c.545delN | p.Pro184LeufsTer11 | p.P184Lfs*11 | Q96G27 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delT | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |