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Gene: UNC93B1 |
Gene summary for UNC93B1 |
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Gene information | Species | Human | Gene symbol | UNC93B1 | Gene ID | 81622 |
Gene name | unc-93 homolog B1, TLR signaling regulator | |
Gene Alias | IIAE1 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | Q9H1C4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81622 | UNC93B1 | LZE5T | Human | Esophagus | ESCC | 4.72e-02 | 2.20e-01 | 0.0514 |
81622 | UNC93B1 | LZE20T | Human | Esophagus | ESCC | 4.91e-14 | 5.53e-01 | 0.0662 |
81622 | UNC93B1 | LZE22T | Human | Esophagus | ESCC | 9.15e-04 | 5.07e-01 | 0.068 |
81622 | UNC93B1 | LZE24T | Human | Esophagus | ESCC | 4.65e-26 | 8.83e-01 | 0.0596 |
81622 | UNC93B1 | P1T-E | Human | Esophagus | ESCC | 5.97e-10 | 5.68e-01 | 0.0875 |
81622 | UNC93B1 | P2T-E | Human | Esophagus | ESCC | 2.55e-25 | 4.05e-01 | 0.1177 |
81622 | UNC93B1 | P4T-E | Human | Esophagus | ESCC | 5.96e-30 | 6.87e-01 | 0.1323 |
81622 | UNC93B1 | P5T-E | Human | Esophagus | ESCC | 1.15e-34 | 6.67e-01 | 0.1327 |
81622 | UNC93B1 | P8T-E | Human | Esophagus | ESCC | 6.49e-47 | 8.76e-01 | 0.0889 |
81622 | UNC93B1 | P9T-E | Human | Esophagus | ESCC | 1.63e-09 | 2.83e-01 | 0.1131 |
81622 | UNC93B1 | P10T-E | Human | Esophagus | ESCC | 6.96e-04 | 5.11e-02 | 0.116 |
81622 | UNC93B1 | P11T-E | Human | Esophagus | ESCC | 4.28e-18 | 5.07e-01 | 0.1426 |
81622 | UNC93B1 | P12T-E | Human | Esophagus | ESCC | 2.84e-10 | 2.08e-01 | 0.1122 |
81622 | UNC93B1 | P15T-E | Human | Esophagus | ESCC | 7.12e-33 | 7.36e-01 | 0.1149 |
81622 | UNC93B1 | P16T-E | Human | Esophagus | ESCC | 4.16e-04 | 1.17e-01 | 0.1153 |
81622 | UNC93B1 | P17T-E | Human | Esophagus | ESCC | 5.57e-07 | 3.41e-01 | 0.1278 |
81622 | UNC93B1 | P20T-E | Human | Esophagus | ESCC | 1.26e-12 | 2.76e-01 | 0.1124 |
81622 | UNC93B1 | P21T-E | Human | Esophagus | ESCC | 1.47e-22 | 4.32e-01 | 0.1617 |
81622 | UNC93B1 | P22T-E | Human | Esophagus | ESCC | 1.28e-37 | 6.95e-01 | 0.1236 |
81622 | UNC93B1 | P23T-E | Human | Esophagus | ESCC | 7.10e-29 | 6.46e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01405467 | Thyroid | PTC | defense response to symbiont | 108/5968 | 265/18723 | 1.34e-03 | 7.55e-03 | 108 |
GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
GO:005160712 | Thyroid | ATC | defense response to virus | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:014054612 | Thyroid | ATC | defense response to symbiont | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNC93B1 | SNV | Missense_Mutation | novel | c.286N>A | p.Glu96Lys | p.E96K | Q9H1C4 | protein_coding | deleterious(0.01) | possibly_damaging(0.466) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
UNC93B1 | SNV | Missense_Mutation | c.1313N>T | p.Ala438Val | p.A438V | Q9H1C4 | protein_coding | tolerated(0.77) | benign(0) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
UNC93B1 | SNV | Missense_Mutation | rs750571331 | c.1517N>T | p.Ala506Val | p.A506V | Q9H1C4 | protein_coding | tolerated(1) | benign(0) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
UNC93B1 | SNV | Missense_Mutation | c.631G>T | p.Gly211Cys | p.G211C | Q9H1C4 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD | ||
UNC93B1 | SNV | Missense_Mutation | novel | c.414N>T | p.Met138Ile | p.M138I | Q9H1C4 | protein_coding | tolerated(0.26) | benign(0.03) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC93B1 | SNV | Missense_Mutation | novel | c.935N>C | p.Arg312Pro | p.R312P | Q9H1C4 | protein_coding | deleterious(0.01) | probably_damaging(0.941) | TCGA-GM-A2DF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
UNC93B1 | SNV | Missense_Mutation | novel | c.1675N>A | p.Gly559Ser | p.G559S | Q9H1C4 | protein_coding | tolerated_low_confidence(0.47) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UNC93B1 | SNV | Missense_Mutation | rs750571331 | c.1517N>T | p.Ala506Val | p.A506V | Q9H1C4 | protein_coding | tolerated(1) | benign(0) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
UNC93B1 | SNV | Missense_Mutation | rs750571331 | c.1517C>T | p.Ala506Val | p.A506V | Q9H1C4 | protein_coding | tolerated(1) | benign(0) | TCGA-LP-A4AU-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
UNC93B1 | SNV | Missense_Mutation | novel | c.1157N>T | p.Ala386Val | p.A386V | Q9H1C4 | protein_coding | tolerated(0.27) | benign(0.343) | TCGA-VS-A954-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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