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Gene: TXNDC12 |
Gene summary for TXNDC12 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TXNDC12 | Gene ID | 51060 |
| Gene name | thioredoxin domain containing 12 | |
| Gene Alias | AG1 | |
| Cytomap | 1p32.3 | |
| Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | O95881 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51060 | TXNDC12 | LZE2D | Human | Esophagus | HGIN | 2.08e-02 | 3.38e-01 | 0.0642 |
| 51060 | TXNDC12 | LZE4T | Human | Esophagus | ESCC | 2.20e-12 | 5.05e-01 | 0.0811 |
| 51060 | TXNDC12 | LZE7T | Human | Esophagus | ESCC | 1.27e-09 | 7.05e-01 | 0.0667 |
| 51060 | TXNDC12 | LZE8T | Human | Esophagus | ESCC | 5.77e-05 | 3.53e-01 | 0.067 |
| 51060 | TXNDC12 | LZE20T | Human | Esophagus | ESCC | 8.91e-06 | 4.68e-01 | 0.0662 |
| 51060 | TXNDC12 | LZE22T | Human | Esophagus | ESCC | 1.80e-07 | 1.12e+00 | 0.068 |
| 51060 | TXNDC12 | LZE24T | Human | Esophagus | ESCC | 9.68e-28 | 8.60e-01 | 0.0596 |
| 51060 | TXNDC12 | LZE21T | Human | Esophagus | ESCC | 1.19e-03 | 5.11e-01 | 0.0655 |
| 51060 | TXNDC12 | LZE6T | Human | Esophagus | ESCC | 1.83e-08 | 8.65e-01 | 0.0845 |
| 51060 | TXNDC12 | P1T-E | Human | Esophagus | ESCC | 5.53e-11 | 6.41e-01 | 0.0875 |
| 51060 | TXNDC12 | P2T-E | Human | Esophagus | ESCC | 4.90e-61 | 1.13e+00 | 0.1177 |
| 51060 | TXNDC12 | P4T-E | Human | Esophagus | ESCC | 5.19e-41 | 1.03e+00 | 0.1323 |
| 51060 | TXNDC12 | P5T-E | Human | Esophagus | ESCC | 3.46e-27 | 7.38e-01 | 0.1327 |
| 51060 | TXNDC12 | P8T-E | Human | Esophagus | ESCC | 6.88e-57 | 1.22e+00 | 0.0889 |
| 51060 | TXNDC12 | P9T-E | Human | Esophagus | ESCC | 1.66e-30 | 8.02e-01 | 0.1131 |
| 51060 | TXNDC12 | P10T-E | Human | Esophagus | ESCC | 3.02e-56 | 1.23e+00 | 0.116 |
| 51060 | TXNDC12 | P11T-E | Human | Esophagus | ESCC | 1.36e-21 | 1.10e+00 | 0.1426 |
| 51060 | TXNDC12 | P12T-E | Human | Esophagus | ESCC | 1.83e-39 | 8.99e-01 | 0.1122 |
| 51060 | TXNDC12 | P15T-E | Human | Esophagus | ESCC | 8.55e-56 | 1.29e+00 | 0.1149 |
| 51060 | TXNDC12 | P16T-E | Human | Esophagus | ESCC | 1.38e-22 | 5.62e-01 | 0.1153 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:190223516 | Esophagus | ESCC | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 24/8552 | 32/18723 | 7.22e-04 | 3.77e-03 | 24 |
| GO:1902236111 | Esophagus | ESCC | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
| GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
| GO:200123312 | Liver | Cirrhotic | regulation of apoptotic signaling pathway | 163/4634 | 356/18723 | 2.62e-18 | 4.43e-16 | 163 |
| GO:009719312 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway | 130/4634 | 288/18723 | 2.69e-14 | 2.45e-12 | 130 |
| GO:20012427 | Liver | Cirrhotic | regulation of intrinsic apoptotic signaling pathway | 82/4634 | 164/18723 | 2.35e-12 | 1.71e-10 | 82 |
| GO:20012347 | Liver | Cirrhotic | negative regulation of apoptotic signaling pathway | 102/4634 | 224/18723 | 8.40e-12 | 5.60e-10 | 102 |
| GO:19058977 | Liver | Cirrhotic | regulation of response to endoplasmic reticulum stress | 46/4634 | 82/18723 | 1.28e-09 | 5.56e-08 | 46 |
| GO:20012437 | Liver | Cirrhotic | negative regulation of intrinsic apoptotic signaling pathway | 47/4634 | 98/18723 | 5.26e-07 | 1.17e-05 | 47 |
| GO:19035737 | Liver | Cirrhotic | negative regulation of response to endoplasmic reticulum stress | 26/4634 | 44/18723 | 1.30e-06 | 2.59e-05 | 26 |
| GO:00700596 | Liver | Cirrhotic | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/4634 | 63/18723 | 1.90e-04 | 1.76e-03 | 29 |
| GO:19022353 | Liver | Cirrhotic | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 17/4634 | 32/18723 | 5.24e-04 | 4.14e-03 | 17 |
| GO:19022367 | Liver | Cirrhotic | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 11/4634 | 20/18723 | 3.61e-03 | 1.99e-02 | 11 |
| GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
| GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
| GO:009719322 | Liver | HCC | intrinsic apoptotic signaling pathway | 184/7958 | 288/18723 | 1.50e-13 | 8.32e-12 | 184 |
| GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
| GO:200124212 | Liver | HCC | regulation of intrinsic apoptotic signaling pathway | 109/7958 | 164/18723 | 4.52e-10 | 1.45e-08 | 109 |
| GO:190589712 | Liver | HCC | regulation of response to endoplasmic reticulum stress | 62/7958 | 82/18723 | 1.06e-09 | 3.23e-08 | 62 |
| GO:200124312 | Liver | HCC | negative regulation of intrinsic apoptotic signaling pathway | 67/7958 | 98/18723 | 1.97e-07 | 3.55e-06 | 67 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
| hsa004809 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
| hsa0048012 | Liver | Cirrhotic | Glutathione metabolism | 30/2530 | 57/8465 | 2.63e-04 | 1.72e-03 | 1.06e-03 | 30 |
| hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
| hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
| hsa0048016 | Oral cavity | OSCC | Glutathione metabolism | 36/3704 | 57/8465 | 2.41e-03 | 6.41e-03 | 3.26e-03 | 36 |
| hsa0048017 | Oral cavity | OSCC | Glutathione metabolism | 36/3704 | 57/8465 | 2.41e-03 | 6.41e-03 | 3.26e-03 | 36 |
| hsa0048024 | Oral cavity | LP | Glutathione metabolism | 25/2418 | 57/8465 | 9.58e-03 | 3.47e-02 | 2.24e-02 | 25 |
| hsa0048034 | Oral cavity | LP | Glutathione metabolism | 25/2418 | 57/8465 | 9.58e-03 | 3.47e-02 | 2.24e-02 | 25 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TXNDC12 | SNV | Missense_Mutation | novel | c.51N>A | p.Phe17Leu | p.F17L | O95881 | protein_coding | tolerated(0.34) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| TXNDC12 | SNV | Missense_Mutation | c.310G>T | p.Asp104Tyr | p.D104Y | O95881 | protein_coding | deleterious(0.04) | probably_damaging(0.911) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TXNDC12 | SNV | Missense_Mutation | rs779015159 | c.359C>T | p.Pro120Leu | p.P120L | O95881 | protein_coding | deleterious(0) | possibly_damaging(0.681) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNDC12 | SNV | Missense_Mutation | novel | c.309A>C | p.Glu103Asp | p.E103D | O95881 | protein_coding | tolerated(0.22) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNDC12 | SNV | Missense_Mutation | novel | c.303N>C | p.Lys101Asn | p.K101N | O95881 | protein_coding | tolerated(0.13) | benign(0.019) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNDC12 | SNV | Missense_Mutation | rs763663263 | c.433N>A | p.Glu145Lys | p.E145K | O95881 | protein_coding | tolerated(0.14) | benign(0.035) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| TXNDC12 | SNV | Missense_Mutation | c.225N>C | p.Lys75Asn | p.K75N | O95881 | protein_coding | deleterious(0.02) | probably_damaging(0.975) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TXNDC12 | SNV | Missense_Mutation | c.58N>A | p.Leu20Ile | p.L20I | O95881 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-BS-A0TA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
| TXNDC12 | SNV | Missense_Mutation | novel | c.106G>A | p.Asp36Asn | p.D36N | O95881 | protein_coding | deleterious(0.01) | benign(0.301) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
| TXNDC12 | SNV | Missense_Mutation | novel | c.283N>C | p.Glu95Gln | p.E95Q | O95881 | protein_coding | tolerated(0.12) | benign(0.33) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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