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Gene: TWSG1 |
Gene summary for TWSG1 |
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Gene information | Species | Human | Gene symbol | TWSG1 | Gene ID | 57045 |
Gene name | twisted gastrulation BMP signaling modulator 1 | |
Gene Alias | TSG | |
Cytomap | 18p11.22 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9GZX9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57045 | TWSG1 | LZE2T | Human | Esophagus | ESCC | 9.37e-05 | 9.51e-01 | 0.082 |
57045 | TWSG1 | LZE7T | Human | Esophagus | ESCC | 2.00e-02 | 3.81e-01 | 0.0667 |
57045 | TWSG1 | LZE22T | Human | Esophagus | ESCC | 3.21e-03 | 9.72e-02 | 0.068 |
57045 | TWSG1 | LZE24T | Human | Esophagus | ESCC | 1.38e-12 | 4.23e-01 | 0.0596 |
57045 | TWSG1 | LZE6T | Human | Esophagus | ESCC | 2.90e-03 | -6.91e-03 | 0.0845 |
57045 | TWSG1 | P1T-E | Human | Esophagus | ESCC | 3.49e-06 | 1.71e-01 | 0.0875 |
57045 | TWSG1 | P2T-E | Human | Esophagus | ESCC | 7.07e-27 | 7.35e-01 | 0.1177 |
57045 | TWSG1 | P4T-E | Human | Esophagus | ESCC | 1.48e-24 | 5.70e-01 | 0.1323 |
57045 | TWSG1 | P5T-E | Human | Esophagus | ESCC | 4.20e-09 | 3.46e-01 | 0.1327 |
57045 | TWSG1 | P8T-E | Human | Esophagus | ESCC | 9.96e-17 | 3.12e-01 | 0.0889 |
57045 | TWSG1 | P9T-E | Human | Esophagus | ESCC | 1.57e-12 | 1.39e-01 | 0.1131 |
57045 | TWSG1 | P10T-E | Human | Esophagus | ESCC | 6.06e-09 | 1.77e-01 | 0.116 |
57045 | TWSG1 | P11T-E | Human | Esophagus | ESCC | 2.06e-06 | 5.16e-01 | 0.1426 |
57045 | TWSG1 | P12T-E | Human | Esophagus | ESCC | 4.95e-31 | 7.79e-01 | 0.1122 |
57045 | TWSG1 | P15T-E | Human | Esophagus | ESCC | 6.06e-10 | 2.56e-01 | 0.1149 |
57045 | TWSG1 | P16T-E | Human | Esophagus | ESCC | 5.85e-19 | 4.26e-01 | 0.1153 |
57045 | TWSG1 | P20T-E | Human | Esophagus | ESCC | 5.88e-12 | 2.22e-01 | 0.1124 |
57045 | TWSG1 | P21T-E | Human | Esophagus | ESCC | 5.33e-28 | 4.34e-01 | 0.1617 |
57045 | TWSG1 | P22T-E | Human | Esophagus | ESCC | 1.96e-24 | 4.93e-01 | 0.1236 |
57045 | TWSG1 | P23T-E | Human | Esophagus | ESCC | 1.76e-27 | 7.51e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071798 | Oral cavity | OSCC | transforming growth factor beta receptor signaling pathway | 109/7305 | 198/18723 | 3.21e-06 | 3.86e-05 | 109 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:002240718 | Oral cavity | OSCC | regulation of cell-cell adhesion | 218/7305 | 448/18723 | 1.71e-05 | 1.68e-04 | 218 |
GO:000164910 | Oral cavity | OSCC | osteoblast differentiation | 118/7305 | 229/18723 | 7.51e-05 | 5.85e-04 | 118 |
GO:005086315 | Oral cavity | OSCC | regulation of T cell activation | 161/7305 | 329/18723 | 1.44e-04 | 1.02e-03 | 161 |
GO:000715916 | Oral cavity | OSCC | leukocyte cell-cell adhesion | 178/7305 | 371/18723 | 2.44e-04 | 1.57e-03 | 178 |
GO:190303715 | Oral cavity | OSCC | regulation of leukocyte cell-cell adhesion | 162/7305 | 336/18723 | 3.39e-04 | 2.08e-03 | 162 |
GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
GO:00073697 | Oral cavity | OSCC | gastrulation | 95/7305 | 185/18723 | 4.17e-04 | 2.54e-03 | 95 |
GO:00017043 | Oral cavity | OSCC | formation of primary germ layer | 65/7305 | 121/18723 | 7.08e-04 | 3.90e-03 | 65 |
GO:004209816 | Oral cavity | OSCC | T cell proliferation | 100/7305 | 199/18723 | 7.93e-04 | 4.27e-03 | 100 |
GO:00071629 | Oral cavity | OSCC | negative regulation of cell adhesion | 145/7305 | 303/18723 | 9.95e-04 | 5.18e-03 | 145 |
GO:002261214 | Oral cavity | OSCC | gland morphogenesis | 62/7305 | 118/18723 | 1.91e-03 | 8.94e-03 | 62 |
GO:00466333 | Oral cavity | OSCC | alpha-beta T cell proliferation | 24/7305 | 38/18723 | 2.21e-03 | 1.00e-02 | 24 |
GO:00071789 | Oral cavity | OSCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 165/7305 | 355/18723 | 2.31e-03 | 1.02e-02 | 165 |
GO:00466403 | Oral cavity | OSCC | regulation of alpha-beta T cell proliferation | 22/7305 | 35/18723 | 3.65e-03 | 1.51e-02 | 22 |
GO:0046642 | Oral cavity | OSCC | negative regulation of alpha-beta T cell proliferation | 10/7305 | 13/18723 | 6.32e-03 | 2.35e-02 | 10 |
GO:00706618 | Oral cavity | OSCC | leukocyte proliferation | 145/7305 | 318/18723 | 9.31e-03 | 3.33e-02 | 145 |
GO:00456674 | Oral cavity | OSCC | regulation of osteoblast differentiation | 65/7305 | 132/18723 | 1.06e-02 | 3.60e-02 | 65 |
GO:0035739 | Oral cavity | OSCC | CD4-positive, alpha-beta T cell proliferation | 9/7305 | 12/18723 | 1.27e-02 | 4.24e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TWSG1 | SNV | Missense_Mutation | c.155A>T | p.Asn52Ile | p.N52I | Q9GZX9 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.331G>C | p.Asp111His | p.D111H | Q9GZX9 | protein_coding | tolerated(0.08) | benign(0.05) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TWSG1 | deletion | Frame_Shift_Del | novel | c.534delN | p.His179IlefsTer41 | p.H179Ifs*41 | Q9GZX9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TWSG1 | SNV | Missense_Mutation | rs376720221 | c.226N>G | p.Met76Val | p.M76V | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.07) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TWSG1 | SNV | Missense_Mutation | c.521N>G | p.Asp174Gly | p.D174G | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.233) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.307N>A | p.Leu103Ile | p.L103I | Q9GZX9 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TWSG1 | SNV | Missense_Mutation | c.251N>T | p.Asp84Val | p.D84V | Q9GZX9 | protein_coding | deleterious(0.03) | possibly_damaging(0.494) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TWSG1 | SNV | Missense_Mutation | c.454N>G | p.Ser152Gly | p.S152G | Q9GZX9 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
TWSG1 | SNV | Missense_Mutation | novel | c.393G>T | p.Glu131Asp | p.E131D | Q9GZX9 | protein_coding | tolerated(0.13) | benign(0.424) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TWSG1 | SNV | Missense_Mutation | c.325N>C | p.Glu109Gln | p.E109Q | Q9GZX9 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-CI-6620-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Ancillary | leucovorin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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