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Gene: TRIM11 |
Gene summary for TRIM11 |
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Gene information | Species | Human | Gene symbol | TRIM11 | Gene ID | 81559 |
Gene name | tripartite motif containing 11 | |
Gene Alias | BIA1 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96F44 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81559 | TRIM11 | LZE7T | Human | Esophagus | ESCC | 4.35e-07 | 2.01e-01 | 0.0667 |
81559 | TRIM11 | LZE20T | Human | Esophagus | ESCC | 1.09e-07 | 1.95e-01 | 0.0662 |
81559 | TRIM11 | LZE21D1 | Human | Esophagus | HGIN | 1.49e-02 | 1.98e-01 | 0.0632 |
81559 | TRIM11 | LZE24T | Human | Esophagus | ESCC | 4.30e-09 | 3.32e-01 | 0.0596 |
81559 | TRIM11 | LZE22D3 | Human | Esophagus | HGIN | 4.34e-02 | 3.75e-01 | 0.0653 |
81559 | TRIM11 | LZE21T | Human | Esophagus | ESCC | 1.98e-02 | 2.78e-01 | 0.0655 |
81559 | TRIM11 | P1T-E | Human | Esophagus | ESCC | 1.99e-10 | 5.34e-01 | 0.0875 |
81559 | TRIM11 | P2T-E | Human | Esophagus | ESCC | 6.69e-20 | 2.76e-01 | 0.1177 |
81559 | TRIM11 | P4T-E | Human | Esophagus | ESCC | 6.84e-08 | 1.44e-01 | 0.1323 |
81559 | TRIM11 | P5T-E | Human | Esophagus | ESCC | 9.50e-18 | 3.65e-01 | 0.1327 |
81559 | TRIM11 | P8T-E | Human | Esophagus | ESCC | 1.98e-13 | 1.58e-01 | 0.0889 |
81559 | TRIM11 | P9T-E | Human | Esophagus | ESCC | 6.06e-13 | 2.31e-01 | 0.1131 |
81559 | TRIM11 | P10T-E | Human | Esophagus | ESCC | 1.11e-19 | 2.23e-01 | 0.116 |
81559 | TRIM11 | P11T-E | Human | Esophagus | ESCC | 1.92e-06 | 3.10e-01 | 0.1426 |
81559 | TRIM11 | P12T-E | Human | Esophagus | ESCC | 9.70e-14 | 2.06e-01 | 0.1122 |
81559 | TRIM11 | P15T-E | Human | Esophagus | ESCC | 1.69e-20 | 5.00e-01 | 0.1149 |
81559 | TRIM11 | P16T-E | Human | Esophagus | ESCC | 3.82e-08 | 2.26e-01 | 0.1153 |
81559 | TRIM11 | P17T-E | Human | Esophagus | ESCC | 5.87e-04 | 2.78e-01 | 0.1278 |
81559 | TRIM11 | P20T-E | Human | Esophagus | ESCC | 1.65e-14 | 3.62e-01 | 0.1124 |
81559 | TRIM11 | P21T-E | Human | Esophagus | ESCC | 1.05e-20 | 3.35e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:001908017 | Esophagus | ESCC | viral gene expression | 80/8552 | 94/18723 | 2.04e-15 | 1.28e-13 | 80 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:0050792111 | Esophagus | ESCC | regulation of viral process | 119/8552 | 164/18723 | 2.19e-12 | 9.03e-11 | 119 |
GO:1903900111 | Esophagus | ESCC | regulation of viral life cycle | 106/8552 | 148/18723 | 1.26e-10 | 3.72e-09 | 106 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:0051701111 | Esophagus | ESCC | biological process involved in interaction with host | 135/8552 | 203/18723 | 1.49e-09 | 3.49e-08 | 135 |
GO:0052126111 | Esophagus | ESCC | movement in host environment | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:0048524110 | Esophagus | ESCC | positive regulation of viral process | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:001908312 | Esophagus | ESCC | viral transcription | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:004852516 | Esophagus | ESCC | negative regulation of viral process | 66/8552 | 92/18723 | 3.49e-07 | 4.88e-06 | 66 |
GO:0044409111 | Esophagus | ESCC | entry into host | 96/8552 | 151/18723 | 6.73e-06 | 6.84e-05 | 96 |
GO:001907614 | Esophagus | ESCC | viral release from host cell | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:003589014 | Esophagus | ESCC | exit from host | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:003589114 | Esophagus | ESCC | exit from host cell | 28/8552 | 34/18723 | 1.21e-05 | 1.12e-04 | 28 |
GO:190390217 | Esophagus | ESCC | positive regulation of viral life cycle | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM11 | SNV | Missense_Mutation | novel | c.1289C>T | p.Pro430Leu | p.P430L | Q96F44 | protein_coding | deleterious(0.03) | benign(0.1) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
TRIM11 | SNV | Missense_Mutation | rs759457960 | c.982N>A | p.Gly328Ser | p.G328S | Q96F44 | protein_coding | tolerated(0.69) | benign(0.007) | TCGA-D8-A141-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
TRIM11 | SNV | Missense_Mutation | rs765073440 | c.1208G>A | p.Arg403His | p.R403H | Q96F44 | protein_coding | tolerated(0.48) | possibly_damaging(0.485) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRIM11 | SNV | Missense_Mutation | c.430G>C | p.Glu144Gln | p.E144Q | Q96F44 | protein_coding | tolerated(0.21) | benign(0.065) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIM11 | SNV | Missense_Mutation | novel | c.1312N>A | p.Leu438Met | p.L438M | Q96F44 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TRIM11 | SNV | Missense_Mutation | c.812C>T | p.Thr271Ile | p.T271I | Q96F44 | protein_coding | deleterious(0.01) | possibly_damaging(0.459) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM11 | SNV | Missense_Mutation | rs766842071 | c.1231N>A | p.Glu411Lys | p.E411K | Q96F44 | protein_coding | deleterious(0) | possibly_damaging(0.546) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRIM11 | SNV | Missense_Mutation | rs766187778 | c.1087N>A | p.Val363Met | p.V363M | Q96F44 | protein_coding | deleterious(0.03) | possibly_damaging(0.47) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRIM11 | SNV | Missense_Mutation | rs766986706 | c.1315C>T | p.Arg439Trp | p.R439W | Q96F44 | protein_coding | tolerated(0.17) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIM11 | SNV | Missense_Mutation | rs751530642 | c.557G>A | p.Arg186His | p.R186H | Q96F44 | protein_coding | tolerated(0.8) | benign(0.007) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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