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Gene: TPRN |
Gene summary for TPRN |
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Gene information | Species | Human | Gene symbol | TPRN | Gene ID | 286262 |
Gene name | taperin | |
Gene Alias | C9orf75 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q4KMQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
286262 | TPRN | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.43e-06 | 3.07e-01 | -0.1808 |
286262 | TPRN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-05 | 2.18e-01 | -0.1954 |
286262 | TPRN | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.20e-05 | 3.28e-01 | -0.1207 |
286262 | TPRN | HTA11_696_2000001011 | Human | Colorectum | AD | 1.10e-06 | 3.23e-01 | -0.1464 |
286262 | TPRN | HTA11_866_2000001011 | Human | Colorectum | AD | 1.35e-02 | 1.79e-01 | -0.1001 |
286262 | TPRN | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.77e-10 | 4.79e-01 | -0.059 |
286262 | TPRN | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.95e-07 | 2.68e-01 | 0.0674 |
286262 | TPRN | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.50e-06 | 1.75e-01 | 0.3859 |
286262 | TPRN | HCC1_Meng | Human | Liver | HCC | 1.25e-25 | 4.96e-02 | 0.0246 |
286262 | TPRN | HCC2_Meng | Human | Liver | HCC | 7.11e-08 | 8.02e-02 | 0.0107 |
286262 | TPRN | HCC2 | Human | Liver | HCC | 1.46e-03 | 3.10e+00 | 0.5341 |
286262 | TPRN | S027 | Human | Liver | HCC | 9.53e-04 | 3.65e-01 | 0.2446 |
286262 | TPRN | S028 | Human | Liver | HCC | 5.73e-09 | 5.32e-01 | 0.2503 |
286262 | TPRN | S029 | Human | Liver | HCC | 6.37e-15 | 7.18e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060117 | Colorectum | AD | auditory receptor cell development | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0035773 | Colorectum | AD | insulin secretion involved in cellular response to glucose stimulus | 27/3918 | 73/18723 | 1.17e-03 | 1.05e-02 | 27 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0060088 | Colorectum | AD | auditory receptor cell stereocilium organization | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:0060119 | Colorectum | AD | inner ear receptor cell development | 17/3918 | 45/18723 | 7.10e-03 | 4.33e-02 | 17 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00439541 | Colorectum | SER | cellular component maintenance | 22/2897 | 61/18723 | 6.47e-05 | 1.49e-03 | 22 |
GO:00342841 | Colorectum | SER | response to monosaccharide | 56/2897 | 225/18723 | 1.52e-04 | 2.98e-03 | 56 |
GO:00097431 | Colorectum | SER | response to carbohydrate | 60/2897 | 253/18723 | 3.66e-04 | 5.67e-03 | 60 |
GO:00097491 | Colorectum | SER | response to glucose | 52/2897 | 212/18723 | 3.75e-04 | 5.74e-03 | 52 |
GO:00064701 | Colorectum | SER | protein dephosphorylation | 65/2897 | 281/18723 | 4.44e-04 | 6.51e-03 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPRN | deletion | Frame_Shift_Del | novel | c.1947delN | p.Leu650CysfsTer110 | p.L650Cfs*110 | Q4KMQ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TPRN | deletion | Frame_Shift_Del | novel | c.1490delN | p.Gly497AlafsTer46 | p.G497Afs*46 | Q4KMQ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TPRN | SNV | Missense_Mutation | novel | c.1651N>C | p.Glu551Gln | p.E551Q | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | c.944T>C | p.Leu315Pro | p.L315P | Q4KMQ1 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-EA-A78R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TPRN | SNV | Missense_Mutation | c.1876N>C | p.Glu626Gln | p.E626Q | Q4KMQ1 | protein_coding | tolerated(0.19) | possibly_damaging(0.686) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TPRN | SNV | Missense_Mutation | c.1657G>A | p.Glu553Lys | p.E553K | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD | |
TPRN | SNV | Missense_Mutation | rs749999995 | c.863N>T | p.Ser288Phe | p.S288F | Q4KMQ1 | protein_coding | deleterious(0) | possibly_damaging(0.795) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | rs754397078 | c.1819N>C | p.Glu607Gln | p.E607Q | Q4KMQ1 | protein_coding | deleterious(0.05) | possibly_damaging(0.829) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | c.974N>G | p.Ala325Gly | p.A325G | Q4KMQ1 | protein_coding | deleterious(0) | benign(0.067) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TPRN | SNV | Missense_Mutation | c.914C>T | p.Pro305Leu | p.P305L | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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