Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/TOP2A_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TOP2A_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TOP2A_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TOP2A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TOP2A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TOP2A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TOP2A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TOP2A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002241113 | Breast | DCIS | cellular component disassembly | 48/1390 | 443/18723 | 5.35e-03 | 3.92e-02 | 48 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0048524 | Colorectum | AD | positive regulation of viral process | 31/3918 | 65/18723 | 1.33e-06 | 4.23e-05 | 31 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:1903900 | Colorectum | AD | regulation of viral life cycle | 51/3918 | 148/18723 | 9.01e-05 | 1.38e-03 | 51 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0045069 | Colorectum | AD | regulation of viral genome replication | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0042752 | Colorectum | AD | regulation of circadian rhythm | 40/3918 | 121/18723 | 1.24e-03 | 1.09e-02 | 40 |
GO:0045070 | Colorectum | AD | positive regulation of viral genome replication | 14/3918 | 30/18723 | 1.43e-03 | 1.22e-02 | 14 |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00190582 | Colorectum | MSS | viral life cycle | 111/3467 | 317/18723 | 1.65e-12 | 2.95e-10 | 111 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00190792 | Colorectum | MSS | viral genome replication | 49/3467 | 131/18723 | 2.73e-07 | 1.11e-05 | 49 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOP2A | SNV | Missense_Mutation | novel | c.4138N>A | p.Glu1380Lys | p.E1380K | P11388 | protein_coding | tolerated(0.53) | benign(0.01) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
TOP2A | SNV | Missense_Mutation | | c.570N>G | p.Phe190Leu | p.F190L | P11388 | protein_coding | tolerated(0.11) | possibly_damaging(0.511) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TOP2A | SNV | Missense_Mutation | rs777230505 | c.3644N>A | p.Arg1215His | p.R1215H | P11388 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AQ-A0Y5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD |
TOP2A | SNV | Missense_Mutation | | c.2843A>G | p.Glu948Gly | p.E948G | P11388 | protein_coding | deleterious(0.03) | benign(0.05) | TCGA-E9-A1RD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TOP2A | insertion | Nonsense_Mutation | novel | c.1399_1400insTTGGTTAAATTGAGGATACTTACGTTTGCTCTTATTTCAT | p.Thr467IlefsTer3 | p.T467Ifs*3 | P11388 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
TOP2A | insertion | Frame_Shift_Ins | novel | c.2071_2072insGCTTATACTTTCAC | p.Thr691SerfsTer8 | p.T691Sfs*8 | P11388 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOP2A | insertion | Nonsense_Mutation | novel | c.1736_1737insTGTTTCAACTGGCTAAA | p.Lys579AsnfsTer6 | p.K579Nfs*6 | P11388 | protein_coding | | | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
TOP2A | SNV | Missense_Mutation | | c.4144G>C | p.Asp1382His | p.D1382H | P11388 | protein_coding | deleterious(0.01) | benign(0.146) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOP2A | SNV | Missense_Mutation | | c.1794G>T | p.Trp598Cys | p.W598C | P11388 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOP2A | insertion | Frame_Shift_Ins | novel | c.4236_4237insGTTTGTAATTTCAGTTTCATCTGGGA | p.Asn1413ValfsTer11 | p.N1413Vfs*11 | P11388 | protein_coding | | | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | inhibitor | CHEMBL1186894 | AMRUBICIN | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | EPIPODOPHYLLOTOXIN 4-(MORPHOLINE)CARBAMATE | CHEMBL1773343 | 21489802 |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | DTS-201 | | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | DOXORUBICIN | DOXORUBICIN | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | ANTHRACYCLINE | | 14978790,15068318 |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | BECATECARIN | BECATECARIN | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | VORELOXIN | VOSAROXIN | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | DOXORUBICIN | DOXORUBICIN | |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | ELLIPTECINE | ELLIPTECINE | 18816045,19783445 |
7153 | TOP2A | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME | | DOXORUBICIN | DOXORUBICIN | |