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Gene: TMEM126A |
Gene summary for TMEM126A |
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Gene information | Species | Human | Gene symbol | TMEM126A | Gene ID | 84233 |
Gene name | transmembrane protein 126A | |
Gene Alias | OPA7 | |
Cytomap | 11q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9H061 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84233 | TMEM126A | LZE4T | Human | Esophagus | ESCC | 6.38e-18 | 2.97e-01 | 0.0811 |
84233 | TMEM126A | LZE7T | Human | Esophagus | ESCC | 5.66e-05 | 1.66e-01 | 0.0667 |
84233 | TMEM126A | LZE8T | Human | Esophagus | ESCC | 4.66e-07 | 1.26e-01 | 0.067 |
84233 | TMEM126A | LZE24T | Human | Esophagus | ESCC | 8.12e-20 | 5.46e-01 | 0.0596 |
84233 | TMEM126A | LZE6T | Human | Esophagus | ESCC | 2.12e-03 | 2.22e-01 | 0.0845 |
84233 | TMEM126A | P1T-E | Human | Esophagus | ESCC | 2.81e-03 | 2.47e-01 | 0.0875 |
84233 | TMEM126A | P2T-E | Human | Esophagus | ESCC | 8.07e-17 | 1.92e-01 | 0.1177 |
84233 | TMEM126A | P4T-E | Human | Esophagus | ESCC | 3.05e-56 | 1.29e+00 | 0.1323 |
84233 | TMEM126A | P5T-E | Human | Esophagus | ESCC | 7.66e-37 | 8.07e-01 | 0.1327 |
84233 | TMEM126A | P8T-E | Human | Esophagus | ESCC | 3.92e-04 | 6.31e-02 | 0.0889 |
84233 | TMEM126A | P9T-E | Human | Esophagus | ESCC | 1.70e-24 | 3.98e-01 | 0.1131 |
84233 | TMEM126A | P10T-E | Human | Esophagus | ESCC | 9.06e-23 | 3.85e-01 | 0.116 |
84233 | TMEM126A | P11T-E | Human | Esophagus | ESCC | 1.06e-21 | 7.47e-01 | 0.1426 |
84233 | TMEM126A | P12T-E | Human | Esophagus | ESCC | 1.96e-27 | 4.83e-01 | 0.1122 |
84233 | TMEM126A | P15T-E | Human | Esophagus | ESCC | 1.69e-09 | 1.29e-01 | 0.1149 |
84233 | TMEM126A | P16T-E | Human | Esophagus | ESCC | 2.26e-24 | 4.85e-01 | 0.1153 |
84233 | TMEM126A | P17T-E | Human | Esophagus | ESCC | 7.93e-11 | 5.39e-01 | 0.1278 |
84233 | TMEM126A | P19T-E | Human | Esophagus | ESCC | 5.19e-15 | 7.38e-01 | 0.1662 |
84233 | TMEM126A | P20T-E | Human | Esophagus | ESCC | 9.70e-13 | 2.34e-01 | 0.1124 |
84233 | TMEM126A | P21T-E | Human | Esophagus | ESCC | 3.90e-61 | 1.28e+00 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032981111 | Thyroid | PTC | mitochondrial respiratory chain complex I assembly | 43/5968 | 57/18723 | 1.73e-11 | 6.81e-10 | 43 |
GO:003310832 | Thyroid | ATC | mitochondrial respiratory chain complex assembly | 65/6293 | 93/18723 | 8.86e-13 | 3.81e-11 | 65 |
GO:001025732 | Thyroid | ATC | NADH dehydrogenase complex assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
GO:003298132 | Thyroid | ATC | mitochondrial respiratory chain complex I assembly | 43/6293 | 57/18723 | 1.20e-10 | 3.75e-09 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM126A | SNV | Missense_Mutation | c.151N>C | p.Asn51His | p.N51H | Q9H061 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
TMEM126A | SNV | Missense_Mutation | novel | c.273N>T | p.Leu91Phe | p.L91F | Q9H061 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM126A | SNV | Missense_Mutation | rs765038408 | c.409N>G | p.Leu137Val | p.L137V | Q9H061 | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM126A | SNV | Missense_Mutation | c.9N>G | p.Asn3Lys | p.N3K | Q9H061 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM126A | SNV | Missense_Mutation | c.218N>T | p.Gly73Val | p.G73V | Q9H061 | protein_coding | tolerated(1) | benign(0) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM126A | insertion | Nonsense_Mutation | novel | c.390_391insAACATGATTTAAAGAAT | p.Ala131AsnfsTer4 | p.A131Nfs*4 | Q9H061 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM126A | SNV | Missense_Mutation | novel | c.514N>C | p.Tyr172His | p.Y172H | Q9H061 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A0GR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM126A | SNV | Missense_Mutation | novel | c.188N>A | p.Ala63Asp | p.A63D | Q9H061 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM126A | SNV | Missense_Mutation | rs377476349 | c.190N>T | p.Arg64Cys | p.R64C | Q9H061 | protein_coding | tolerated(0.11) | possibly_damaging(0.828) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM126A | SNV | Missense_Mutation | novel | c.514T>C | p.Tyr172His | p.Y172H | Q9H061 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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