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Gene: TIMM23 |
Gene summary for TIMM23 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TIMM23 | Gene ID | 100287932 |
| Gene name | translocase of inner mitochondrial membrane 23 | |
| Gene Alias | TIM23 | |
| Cytomap | 10q11.22 | |
| Gene Type | protein-coding | GO ID | GO:0006605 | UniProtAcc | O14925 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100287932 | TIMM23 | LZE2T | Human | Esophagus | ESCC | 3.43e-04 | 6.98e-01 | 0.082 |
| 100287932 | TIMM23 | LZE4T | Human | Esophagus | ESCC | 9.41e-11 | 2.28e-01 | 0.0811 |
| 100287932 | TIMM23 | LZE5T | Human | Esophagus | ESCC | 3.81e-04 | 3.67e-01 | 0.0514 |
| 100287932 | TIMM23 | LZE7T | Human | Esophagus | ESCC | 3.67e-07 | 3.40e-01 | 0.0667 |
| 100287932 | TIMM23 | LZE8T | Human | Esophagus | ESCC | 3.45e-08 | 4.07e-01 | 0.067 |
| 100287932 | TIMM23 | LZE20T | Human | Esophagus | ESCC | 3.89e-06 | 1.76e-01 | 0.0662 |
| 100287932 | TIMM23 | LZE24T | Human | Esophagus | ESCC | 8.33e-25 | 8.17e-01 | 0.0596 |
| 100287932 | TIMM23 | LZE21T | Human | Esophagus | ESCC | 2.92e-03 | 3.71e-01 | 0.0655 |
| 100287932 | TIMM23 | LZE6T | Human | Esophagus | ESCC | 1.42e-07 | 3.08e-01 | 0.0845 |
| 100287932 | TIMM23 | P1T-E | Human | Esophagus | ESCC | 4.04e-04 | 4.61e-01 | 0.0875 |
| 100287932 | TIMM23 | P2T-E | Human | Esophagus | ESCC | 4.64e-23 | 5.24e-01 | 0.1177 |
| 100287932 | TIMM23 | P4T-E | Human | Esophagus | ESCC | 2.23e-34 | 1.10e+00 | 0.1323 |
| 100287932 | TIMM23 | P5T-E | Human | Esophagus | ESCC | 2.27e-40 | 8.10e-01 | 0.1327 |
| 100287932 | TIMM23 | P8T-E | Human | Esophagus | ESCC | 1.00e-24 | 5.97e-01 | 0.0889 |
| 100287932 | TIMM23 | P9T-E | Human | Esophagus | ESCC | 1.10e-22 | 3.00e-01 | 0.1131 |
| 100287932 | TIMM23 | P10T-E | Human | Esophagus | ESCC | 5.14e-23 | 4.45e-01 | 0.116 |
| 100287932 | TIMM23 | P11T-E | Human | Esophagus | ESCC | 3.94e-15 | 8.64e-01 | 0.1426 |
| 100287932 | TIMM23 | P12T-E | Human | Esophagus | ESCC | 8.11e-33 | 7.10e-01 | 0.1122 |
| 100287932 | TIMM23 | P15T-E | Human | Esophagus | ESCC | 1.04e-28 | 7.43e-01 | 0.1149 |
| 100287932 | TIMM23 | P16T-E | Human | Esophagus | ESCC | 1.32e-17 | 3.55e-01 | 0.1153 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
| GO:19905422 | Colorectum | MSS | mitochondrial transmembrane transport | 41/3467 | 102/18723 | 2.70e-07 | 1.11e-05 | 41 |
| GO:00705852 | Colorectum | MSS | protein localization to mitochondrion | 47/3467 | 125/18723 | 3.98e-07 | 1.58e-05 | 47 |
| GO:00726552 | Colorectum | MSS | establishment of protein localization to mitochondrion | 44/3467 | 120/18723 | 2.03e-06 | 6.28e-05 | 44 |
| GO:00170382 | Colorectum | MSS | protein import | 65/3467 | 206/18723 | 4.28e-06 | 1.22e-04 | 65 |
| GO:00066262 | Colorectum | MSS | protein targeting to mitochondrion | 36/3467 | 100/18723 | 2.65e-05 | 5.46e-04 | 36 |
| GO:00718062 | Colorectum | MSS | protein transmembrane transport | 20/3467 | 59/18723 | 3.53e-03 | 2.63e-02 | 20 |
| GO:0065002 | Colorectum | MSS | intracellular protein transmembrane transport | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
| GO:00725944 | Colorectum | FAP | establishment of protein localization to organelle | 96/2622 | 422/18723 | 6.63e-07 | 3.20e-05 | 96 |
| GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
| GO:19905423 | Colorectum | FAP | mitochondrial transmembrane transport | 29/2622 | 102/18723 | 1.09e-04 | 1.80e-03 | 29 |
| GO:00170384 | Colorectum | FAP | protein import | 47/2622 | 206/18723 | 4.10e-04 | 4.94e-03 | 47 |
| GO:00068394 | Colorectum | FAP | mitochondrial transport | 55/2622 | 254/18723 | 5.58e-04 | 6.24e-03 | 55 |
| GO:00650021 | Colorectum | FAP | intracellular protein transmembrane transport | 14/2622 | 51/18723 | 8.70e-03 | 4.98e-02 | 14 |
| GO:00725945 | Colorectum | CRC | establishment of protein localization to organelle | 74/2078 | 422/18723 | 4.38e-05 | 1.05e-03 | 74 |
| GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
| GO:00170385 | Colorectum | CRC | protein import | 38/2078 | 206/18723 | 1.14e-03 | 1.31e-02 | 38 |
| GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
| GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
| GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TIMM23 | SNV | Missense_Mutation | novel | c.82C>T | p.His28Tyr | p.H28Y | O14925 | protein_coding | deleterious(0.03) | benign(0.139) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.335N>T | p.Arg112Ile | p.R112I | O14925 | protein_coding | deleterious(0) | possibly_damaging(0.701) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| TIMM23 | SNV | Missense_Mutation | novel | c.266N>T | p.Ala89Val | p.A89V | O14925 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.415A>G | p.Ser139Gly | p.S139G | O14925 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.215G>A | p.Arg72Lys | p.R72K | O14925 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.520N>A | p.Leu174Ile | p.L174I | O14925 | protein_coding | tolerated(0.1) | benign(0.084) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.113N>T | p.Gly38Val | p.G38V | O14925 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AX-A05T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.338A>T | p.Asn113Ile | p.N113I | O14925 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.524N>A | p.Arg175Gln | p.R175Q | O14925 | protein_coding | tolerated(0.29) | benign(0.009) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| TIMM23 | SNV | Missense_Mutation | novel | c.260N>A | p.Gly87Glu | p.G87E | O14925 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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