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Gene: THUMPD3 |
Gene summary for THUMPD3 |
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Gene information | Species | Human | Gene symbol | THUMPD3 | Gene ID | 25917 |
Gene name | THUMP domain containing 3 | |
Gene Alias | THUMPD3 | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | A0A024R2F4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25917 | THUMPD3 | LZE4T | Human | Esophagus | ESCC | 1.36e-08 | 2.04e-01 | 0.0811 |
25917 | THUMPD3 | LZE7T | Human | Esophagus | ESCC | 7.88e-04 | 1.38e-01 | 0.0667 |
25917 | THUMPD3 | LZE20T | Human | Esophagus | ESCC | 1.81e-02 | 3.92e-02 | 0.0662 |
25917 | THUMPD3 | LZE24T | Human | Esophagus | ESCC | 4.10e-11 | 2.02e-01 | 0.0596 |
25917 | THUMPD3 | LZE21T | Human | Esophagus | ESCC | 1.41e-02 | 1.49e-01 | 0.0655 |
25917 | THUMPD3 | LZE6T | Human | Esophagus | ESCC | 1.59e-03 | 2.09e-01 | 0.0845 |
25917 | THUMPD3 | P1T-E | Human | Esophagus | ESCC | 3.87e-09 | 3.42e-01 | 0.0875 |
25917 | THUMPD3 | P2T-E | Human | Esophagus | ESCC | 5.12e-30 | 4.29e-01 | 0.1177 |
25917 | THUMPD3 | P4T-E | Human | Esophagus | ESCC | 2.55e-28 | 6.15e-01 | 0.1323 |
25917 | THUMPD3 | P5T-E | Human | Esophagus | ESCC | 2.76e-36 | 7.00e-01 | 0.1327 |
25917 | THUMPD3 | P8T-E | Human | Esophagus | ESCC | 6.41e-15 | 2.38e-01 | 0.0889 |
25917 | THUMPD3 | P9T-E | Human | Esophagus | ESCC | 6.42e-05 | 1.58e-01 | 0.1131 |
25917 | THUMPD3 | P10T-E | Human | Esophagus | ESCC | 2.13e-13 | 2.21e-01 | 0.116 |
25917 | THUMPD3 | P11T-E | Human | Esophagus | ESCC | 1.07e-11 | 5.28e-01 | 0.1426 |
25917 | THUMPD3 | P12T-E | Human | Esophagus | ESCC | 5.35e-24 | 4.33e-01 | 0.1122 |
25917 | THUMPD3 | P15T-E | Human | Esophagus | ESCC | 1.40e-12 | 2.33e-01 | 0.1149 |
25917 | THUMPD3 | P16T-E | Human | Esophagus | ESCC | 3.81e-31 | 3.87e-01 | 0.1153 |
25917 | THUMPD3 | P17T-E | Human | Esophagus | ESCC | 8.38e-06 | 1.81e-01 | 0.1278 |
25917 | THUMPD3 | P19T-E | Human | Esophagus | ESCC | 3.09e-10 | 3.77e-01 | 0.1662 |
25917 | THUMPD3 | P20T-E | Human | Esophagus | ESCC | 1.98e-16 | 3.70e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
GO:00434142 | Oral cavity | OSCC | macromolecule methylation | 149/7305 | 316/18723 | 1.82e-03 | 8.60e-03 | 149 |
GO:00322591 | Oral cavity | OSCC | methylation | 168/7305 | 364/18723 | 3.03e-03 | 1.31e-02 | 168 |
GO:003447013 | Prostate | Tumor | ncRNA processing | 94/3246 | 395/18723 | 6.02e-04 | 4.31e-03 | 94 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:004341411 | Skin | cSCC | macromolecule methylation | 107/4864 | 316/18723 | 1.03e-03 | 6.94e-03 | 107 |
GO:00080334 | Skin | cSCC | tRNA processing | 49/4864 | 127/18723 | 1.20e-03 | 7.81e-03 | 49 |
GO:00322593 | Skin | cSCC | methylation | 120/4864 | 364/18723 | 1.61e-03 | 9.93e-03 | 120 |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
GO:00094513 | Skin | cSCC | RNA modification | 58/4864 | 167/18723 | 7.33e-03 | 3.47e-02 | 58 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THUMPD3 | SNV | Missense_Mutation | novel | c.991N>T | p.Gly331Trp | p.G331W | Q9BV44 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
THUMPD3 | SNV | Missense_Mutation | novel | c.120N>G | p.Ile40Met | p.I40M | Q9BV44 | protein_coding | deleterious(0) | possibly_damaging(0.826) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
THUMPD3 | SNV | Missense_Mutation | novel | c.1285N>A | p.Glu429Lys | p.E429K | Q9BV44 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1JS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
THUMPD3 | SNV | Missense_Mutation | rs766648779 | c.526A>T | p.Thr176Ser | p.T176S | Q9BV44 | protein_coding | tolerated(0.77) | benign(0) | TCGA-E2-A1L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
THUMPD3 | insertion | Nonsense_Mutation | novel | c.166_167insAGATCTTGTGAGACTTATTCACTACCACAAGAACAGTA | p.Val56GlufsTer4 | p.V56Efs*4 | Q9BV44 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
THUMPD3 | SNV | Missense_Mutation | novel | c.31N>T | p.Leu11Phe | p.L11F | Q9BV44 | protein_coding | tolerated_low_confidence(0.14) | benign(0.007) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
THUMPD3 | SNV | Missense_Mutation | novel | c.977N>A | p.Pro326Gln | p.P326Q | Q9BV44 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THUMPD3 | SNV | Missense_Mutation | c.1114A>T | p.Ile372Phe | p.I372F | Q9BV44 | protein_coding | tolerated(0.05) | possibly_damaging(0.49) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
THUMPD3 | SNV | Missense_Mutation | c.1519G>A | p.Glu507Lys | p.E507K | Q9BV44 | protein_coding | tolerated_low_confidence(0.05) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
THUMPD3 | SNV | Missense_Mutation | rs140248268 | c.541N>T | p.Asp181Tyr | p.D181Y | Q9BV44 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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