GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064866 | Thyroid | PTC | protein glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:00434136 | Thyroid | PTC | macromolecule glycosylation | 94/5968 | 226/18723 | 1.25e-03 | 7.13e-03 | 94 |
GO:0031507 | Thyroid | PTC | heterochromatin assembly | 22/5968 | 39/18723 | 1.32e-03 | 7.47e-03 | 22 |
GO:00018246 | Thyroid | PTC | blastocyst development | 49/5968 | 106/18723 | 1.37e-03 | 7.72e-03 | 49 |
GO:00458142 | Thyroid | PTC | negative regulation of gene expression, epigenetic | 26/5968 | 50/18723 | 2.44e-03 | 1.27e-02 | 26 |
GO:00708282 | Thyroid | PTC | heterochromatin organization | 24/5968 | 46/18723 | 3.34e-03 | 1.63e-02 | 24 |
GO:00700855 | Thyroid | PTC | glycosylation | 96/5968 | 240/18723 | 4.57e-03 | 2.15e-02 | 96 |
GO:00091013 | Thyroid | PTC | glycoprotein biosynthetic process | 123/5968 | 317/18723 | 5.05e-03 | 2.33e-02 | 123 |
GO:00091003 | Thyroid | PTC | glycoprotein metabolic process | 147/5968 | 387/18723 | 5.87e-03 | 2.64e-02 | 147 |
GO:00609688 | Thyroid | PTC | regulation of gene silencing | 36/5968 | 81/18723 | 1.18e-02 | 4.64e-02 | 36 |
GO:001657017 | Thyroid | ATC | histone modification | 243/6293 | 463/18723 | 2.23e-17 | 2.27e-15 | 243 |
GO:004670024 | Thyroid | ATC | heterocycle catabolic process | 228/6293 | 445/18723 | 7.26e-15 | 4.50e-13 | 228 |
GO:004427025 | Thyroid | ATC | cellular nitrogen compound catabolic process | 229/6293 | 451/18723 | 2.25e-14 | 1.27e-12 | 229 |
GO:001943924 | Thyroid | ATC | aromatic compound catabolic process | 232/6293 | 467/18723 | 3.05e-13 | 1.44e-11 | 232 |
GO:190136124 | Thyroid | ATC | organic cyclic compound catabolic process | 238/6293 | 495/18723 | 1.12e-11 | 4.12e-10 | 238 |
GO:000170126 | Thyroid | ATC | in utero embryonic development | 183/6293 | 367/18723 | 6.62e-11 | 2.11e-09 | 183 |
GO:003105616 | Thyroid | ATC | regulation of histone modification | 85/6293 | 152/18723 | 1.23e-08 | 2.55e-07 | 85 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:003105811 | Thyroid | ATC | positive regulation of histone modification | 52/6293 | 92/18723 | 5.21e-06 | 5.61e-05 | 52 |
GO:009872722 | Thyroid | ATC | maintenance of cell number | 70/6293 | 134/18723 | 6.45e-06 | 6.69e-05 | 70 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TET1 | ECM | Lung | AAH | GPR137C,AP001636.3,PLEKHA7, etc. | 4.29e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AAH/regulons_activity_in_dotplot.png) |
TET1 | ECM | Lung | ADJ | GPR137C,AP001636.3,PLEKHA7, etc. | 3.95e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TET1 | MYOFIB | Lung | ADJ | GPR137C,AP001636.3,PLEKHA7, etc. | 1.81e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TET1 | FIB | Lung | ADJ | GPR137C,AP001636.3,PLEKHA7, etc. | 1.29e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
TET1 | ECM | Lung | AIS | GPR137C,AP001636.3,PLEKHA7, etc. | 4.29e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AIS/regulons_activity_in_dotplot.png) |
TET1 | FIB | Lung | IAC | GPR137C,AP001636.3,PLEKHA7, etc. | 2.65e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TET1 | MYOFIB | Lung | IAC | GPR137C,AP001636.3,PLEKHA7, etc. | 3.10e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_IAC/regulons_activity_in_dotplot.png) |
TET1 | ECM | Lung | MIAC | GPR137C,AP001636.3,PLEKHA7, etc. | 3.90e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_MIAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TET1 | SNV | Missense_Mutation | novel | c.3184N>A | p.Asp1062Asn | p.D1062N | Q8NFU7 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
TET1 | SNV | Missense_Mutation | rs778536892 | c.23G>A | p.Arg8Lys | p.R8K | Q8NFU7 | protein_coding | tolerated(0.49) | benign(0.018) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
TET1 | SNV | Missense_Mutation | novel | c.4185T>A | p.Phe1395Leu | p.F1395L | Q8NFU7 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | | c.1580C>T | p.Ser527Leu | p.S527L | Q8NFU7 | protein_coding | tolerated(0.12) | benign(0) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | novel | c.3095N>T | p.Ser1032Phe | p.S1032F | Q8NFU7 | protein_coding | tolerated(0.09) | benign(0.021) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
TET1 | SNV | Missense_Mutation | novel | c.554N>A | p.Ser185Asn | p.S185N | Q8NFU7 | protein_coding | tolerated(0.15) | possibly_damaging(0.459) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | novel | c.984N>C | p.Lys328Asn | p.K328N | Q8NFU7 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | rs538486517 | c.1452N>T | p.Glu484Asp | p.E484D | Q8NFU7 | protein_coding | deleterious(0.02) | benign(0.28) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | rs369109149 | c.2234N>A | p.Arg745Gln | p.R745Q | Q8NFU7 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | novel | c.2594N>C | p.Lys865Thr | p.K865T | Q8NFU7 | protein_coding | tolerated(0.12) | benign(0.01) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |