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Gene: TENM1 |
Gene summary for TENM1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TENM1 | Gene ID | 10178 |
| Gene name | teneurin transmembrane protein 1 | |
| Gene Alias | ODZ1 | |
| Cytomap | Xq25 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9UKZ4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10178 | TENM1 | NAFLD1 | Human | Liver | NAFLD | 4.11e-09 | 9.67e-01 | -0.04 |
| 10178 | TENM1 | S43 | Human | Liver | Cirrhotic | 2.30e-06 | -1.83e-01 | -0.0187 |
| 10178 | TENM1 | HCC1_Meng | Human | Liver | HCC | 7.26e-19 | -1.23e-01 | 0.0246 |
| 10178 | TENM1 | HCC2_Meng | Human | Liver | HCC | 5.01e-07 | -1.83e-01 | 0.0107 |
| 10178 | TENM1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.05e-05 | -1.83e-01 | 0.0202 |
| 10178 | TENM1 | cirrhotic2 | Human | Liver | Cirrhotic | 2.30e-06 | -1.83e-01 | 0.0201 |
| 10178 | TENM1 | cirrhotic3 | Human | Liver | Cirrhotic | 2.51e-02 | -1.83e-01 | 0.0215 |
| 10178 | TENM1 | HCC1 | Human | Liver | HCC | 3.93e-02 | 2.95e+00 | 0.5336 |
| 10178 | TENM1 | HCC2 | Human | Liver | HCC | 4.46e-06 | 2.93e+00 | 0.5341 |
| 10178 | TENM1 | Pt13.a | Human | Liver | HCC | 2.30e-06 | -1.83e-01 | 0.021 |
| 10178 | TENM1 | Pt14.d | Human | Liver | HCC | 2.30e-06 | -1.83e-01 | 0.0143 |
| 10178 | TENM1 | male-WTA | Human | Thyroid | PTC | 3.28e-16 | 2.89e-01 | 0.1037 |
| 10178 | TENM1 | female-WTA | Human | Thyroid | PTC | 2.08e-02 | 2.87e-01 | 0.0726 |
| 10178 | TENM1 | PTC01 | Human | Thyroid | PTC | 2.00e-43 | 9.15e-01 | 0.1899 |
| 10178 | TENM1 | PTC03 | Human | Thyroid | PTC | 1.10e-12 | 5.51e-01 | 0.1784 |
| 10178 | TENM1 | PTC04 | Human | Thyroid | PTC | 6.01e-94 | 1.81e+00 | 0.1927 |
| 10178 | TENM1 | PTC05 | Human | Thyroid | PTC | 9.48e-35 | 1.20e+00 | 0.2065 |
| 10178 | TENM1 | PTC06 | Human | Thyroid | PTC | 1.45e-58 | 1.42e+00 | 0.2057 |
| 10178 | TENM1 | PTC07 | Human | Thyroid | PTC | 8.07e-80 | 1.39e+00 | 0.2044 |
| 10178 | TENM1 | ATC13 | Human | Thyroid | ATC | 2.29e-02 | 7.26e-02 | 0.34 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00331576 | Liver | NAFLD | regulation of intracellular protein transport | 37/1882 | 229/18723 | 2.55e-03 | 2.36e-02 | 37 |
| GO:00322737 | Liver | NAFLD | positive regulation of protein polymerization | 25/1882 | 138/18723 | 2.61e-03 | 2.41e-02 | 25 |
| GO:00325356 | Liver | NAFLD | regulation of cellular component size | 55/1882 | 383/18723 | 4.31e-03 | 3.55e-02 | 55 |
| GO:00300417 | Liver | NAFLD | actin filament polymerization | 31/1882 | 191/18723 | 5.06e-03 | 3.96e-02 | 31 |
| GO:00323866 | Liver | NAFLD | regulation of intracellular transport | 49/1882 | 337/18723 | 5.34e-03 | 4.11e-02 | 49 |
| GO:00323886 | Liver | NAFLD | positive regulation of intracellular transport | 32/1882 | 202/18723 | 6.42e-03 | 4.69e-02 | 32 |
| GO:00308337 | Liver | NAFLD | regulation of actin filament polymerization | 28/1882 | 172/18723 | 7.15e-03 | 4.96e-02 | 28 |
| GO:00719005 | Liver | NAFLD | regulation of protein serine/threonine kinase activity | 51/1882 | 359/18723 | 7.17e-03 | 4.96e-02 | 51 |
| GO:003238611 | Liver | Cirrhotic | regulation of intracellular transport | 147/4634 | 337/18723 | 1.84e-14 | 1.72e-12 | 147 |
| GO:003315711 | Liver | Cirrhotic | regulation of intracellular protein transport | 108/4634 | 229/18723 | 1.23e-13 | 1.04e-11 | 108 |
| GO:190495112 | Liver | Cirrhotic | positive regulation of establishment of protein localization | 135/4634 | 319/18723 | 3.20e-12 | 2.28e-10 | 135 |
| GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
| GO:000701512 | Liver | Cirrhotic | actin filament organization | 171/4634 | 442/18723 | 3.93e-11 | 2.30e-09 | 171 |
| GO:005122212 | Liver | Cirrhotic | positive regulation of protein transport | 126/4634 | 303/18723 | 6.85e-11 | 3.77e-09 | 126 |
| GO:003238811 | Liver | Cirrhotic | positive regulation of intracellular transport | 92/4634 | 202/18723 | 8.60e-11 | 4.66e-09 | 92 |
| GO:009031611 | Liver | Cirrhotic | positive regulation of intracellular protein transport | 77/4634 | 160/18723 | 1.17e-10 | 6.21e-09 | 77 |
| GO:190290312 | Liver | Cirrhotic | regulation of supramolecular fiber organization | 148/4634 | 383/18723 | 8.85e-10 | 4.08e-08 | 148 |
| GO:003297012 | Liver | Cirrhotic | regulation of actin filament-based process | 152/4634 | 397/18723 | 1.12e-09 | 5.00e-08 | 152 |
| GO:003295612 | Liver | Cirrhotic | regulation of actin cytoskeleton organization | 136/4634 | 358/18723 | 1.47e-08 | 5.49e-07 | 136 |
| GO:005125812 | Liver | Cirrhotic | protein polymerization | 116/4634 | 297/18723 | 2.87e-08 | 9.78e-07 | 116 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TENM1 | SNV | Missense_Mutation | novel | c.2285N>A | p.Arg762Gln | p.R762Q | Q9UKZ4 | protein_coding | tolerated(0.2) | benign(0) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
| TENM1 | SNV | Missense_Mutation | novel | c.3210N>T | p.Trp1070Cys | p.W1070C | Q9UKZ4 | protein_coding | deleterious(0.03) | benign(0.237) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
| TENM1 | SNV | Missense_Mutation | c.3745G>T | p.Ala1249Ser | p.A1249S | Q9UKZ4 | protein_coding | deleterious(0.05) | benign(0.14) | TCGA-A2-A0T3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| TENM1 | SNV | Missense_Mutation | novel | c.5852C>A | p.Thr1951Asn | p.T1951N | Q9UKZ4 | protein_coding | deleterious(0.02) | benign(0.034) | TCGA-A7-A3IY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
| TENM1 | SNV | Missense_Mutation | rs758151979 | c.2608N>A | p.Asp870Asn | p.D870N | Q9UKZ4 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
| TENM1 | SNV | Missense_Mutation | c.1548N>C | p.Met516Ile | p.M516I | Q9UKZ4 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| TENM1 | SNV | Missense_Mutation | c.6070N>G | p.Gln2024Glu | p.Q2024E | Q9UKZ4 | protein_coding | deleterious(0.02) | benign(0.057) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TENM1 | SNV | Missense_Mutation | c.3254A>C | p.Lys1085Thr | p.K1085T | Q9UKZ4 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| TENM1 | SNV | Missense_Mutation | c.7543N>A | p.Glu2515Lys | p.E2515K | Q9UKZ4 | protein_coding | tolerated(0.52) | benign(0.038) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TENM1 | SNV | Missense_Mutation | novel | c.4348N>A | p.Glu1450Lys | p.E1450K | Q9UKZ4 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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