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Gene: TDP1 |
Gene summary for TDP1 |
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Gene information | Species | Human | Gene symbol | TDP1 | Gene ID | 55775 |
Gene name | tyrosyl-DNA phosphodiesterase 1 | |
Gene Alias | TDP1 | |
Cytomap | 14q32.11 | |
Gene Type | protein-coding | GO ID | GO:0000012 | UniProtAcc | A0A024R6L5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55775 | TDP1 | LZE4T | Human | Esophagus | ESCC | 1.15e-05 | 1.21e-01 | 0.0811 |
55775 | TDP1 | LZE7T | Human | Esophagus | ESCC | 2.58e-03 | 1.45e-01 | 0.0667 |
55775 | TDP1 | LZE24T | Human | Esophagus | ESCC | 2.23e-09 | 1.88e-01 | 0.0596 |
55775 | TDP1 | P1T-E | Human | Esophagus | ESCC | 9.50e-03 | 1.34e-01 | 0.0875 |
55775 | TDP1 | P2T-E | Human | Esophagus | ESCC | 2.08e-08 | 2.21e-01 | 0.1177 |
55775 | TDP1 | P4T-E | Human | Esophagus | ESCC | 2.17e-11 | 3.20e-01 | 0.1323 |
55775 | TDP1 | P5T-E | Human | Esophagus | ESCC | 5.40e-06 | 1.53e-01 | 0.1327 |
55775 | TDP1 | P8T-E | Human | Esophagus | ESCC | 1.60e-05 | 1.37e-01 | 0.0889 |
55775 | TDP1 | P10T-E | Human | Esophagus | ESCC | 5.23e-12 | 2.33e-01 | 0.116 |
55775 | TDP1 | P11T-E | Human | Esophagus | ESCC | 1.32e-04 | 1.76e-01 | 0.1426 |
55775 | TDP1 | P12T-E | Human | Esophagus | ESCC | 1.73e-18 | 2.92e-01 | 0.1122 |
55775 | TDP1 | P15T-E | Human | Esophagus | ESCC | 2.99e-12 | 3.15e-01 | 0.1149 |
55775 | TDP1 | P16T-E | Human | Esophagus | ESCC | 2.22e-09 | 2.11e-01 | 0.1153 |
55775 | TDP1 | P17T-E | Human | Esophagus | ESCC | 1.17e-02 | 2.38e-01 | 0.1278 |
55775 | TDP1 | P20T-E | Human | Esophagus | ESCC | 8.33e-07 | 1.46e-01 | 0.1124 |
55775 | TDP1 | P21T-E | Human | Esophagus | ESCC | 8.00e-11 | 1.80e-01 | 0.1617 |
55775 | TDP1 | P22T-E | Human | Esophagus | ESCC | 1.64e-03 | 6.23e-02 | 0.1236 |
55775 | TDP1 | P23T-E | Human | Esophagus | ESCC | 8.85e-07 | 1.61e-01 | 0.108 |
55775 | TDP1 | P24T-E | Human | Esophagus | ESCC | 1.82e-05 | 1.70e-01 | 0.1287 |
55775 | TDP1 | P26T-E | Human | Esophagus | ESCC | 1.17e-08 | 2.00e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00303084 | Oral cavity | OSCC | negative regulation of cell growth | 101/7305 | 188/18723 | 2.85e-05 | 2.63e-04 | 101 |
GO:00517029 | Oral cavity | OSCC | biological process involved in interaction with symbiont | 54/7305 | 94/18723 | 2.20e-04 | 1.44e-03 | 54 |
GO:0010458 | Oral cavity | OSCC | exit from mitosis | 21/7305 | 29/18723 | 2.73e-04 | 1.73e-03 | 21 |
GO:00485889 | Oral cavity | OSCC | developmental cell growth | 116/7305 | 234/18723 | 6.20e-04 | 3.50e-03 | 116 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
GO:00439232 | Oral cavity | OSCC | positive regulation by host of viral transcription | 12/7305 | 16/18723 | 3.83e-03 | 1.57e-02 | 12 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa034104 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa0341011 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TDP1 | SNV | Missense_Mutation | rs766476915 | c.1459N>T | p.Arg487Cys | p.R487C | Q9NUW8 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TDP1 | SNV | Missense_Mutation | c.377N>C | p.Arg126Thr | p.R126T | Q9NUW8 | protein_coding | tolerated(0.09) | benign(0) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDP1 | SNV | Missense_Mutation | c.436N>A | p.Glu146Lys | p.E146K | Q9NUW8 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TDP1 | SNV | Missense_Mutation | rs772139596 | c.1799N>T | p.Thr600Met | p.T600M | Q9NUW8 | protein_coding | deleterious(0.01) | possibly_damaging(0.89) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDP1 | SNV | Missense_Mutation | c.1571N>T | p.Ala524Val | p.A524V | Q9NUW8 | protein_coding | tolerated(0.13) | benign(0.013) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
TDP1 | SNV | Missense_Mutation | c.1177C>T | p.Pro393Ser | p.P393S | Q9NUW8 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TDP1 | SNV | Missense_Mutation | rs765018747 | c.1219N>A | p.Asp407Asn | p.D407N | Q9NUW8 | protein_coding | tolerated(0.06) | benign(0.401) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDP1 | SNV | Missense_Mutation | novel | c.97C>A | p.Leu33Ile | p.L33I | Q9NUW8 | protein_coding | tolerated_low_confidence(0.15) | benign(0.014) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDP1 | SNV | Missense_Mutation | novel | c.97N>A | p.Leu33Ile | p.L33I | Q9NUW8 | protein_coding | tolerated_low_confidence(0.15) | benign(0.014) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TDP1 | SNV | Missense_Mutation | novel | c.1289C>T | p.Pro430Leu | p.P430L | Q9NUW8 | protein_coding | tolerated(0.79) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | FUMARPROTOCETRARIC ACID | FUMARPROTOCETRARIC ACID | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | TESTOSTERONE | TESTOSTERONE | 19883083 | |
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | ELLIPTECINE | ELLIPTECINE | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | PROTOPORPHYRIN | PROTOPORPHYRIN | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | ORTHO-PHTHALALDEHYDE | ORTHO-PHTHALALDEHYDE | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | NIMESULIDE | NIMESULIDE | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | BENZYL SALICYLATE | BENZYL SALICYLATE | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | AMPICILLIN TRIHYDRATE | AMPICILLIN TRIHYDRATE | ||
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | NSC-88915 | CHEMBL387152 | 19883083 | |
55775 | TDP1 | DRUGGABLE GENOME, ENZYME, DNA REPAIR | NOREPINEPHRINE | NOREPINEPHRINE |
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