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Gene: TAF9 |
Gene summary for TAF9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TAF9 | Gene ID | 6880 |
| Gene name | TATA-box binding protein associated factor 9 | |
| Gene Alias | MGC:5067 | |
| Cytomap | 5q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0000491 | UniProtAcc | Q16594 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 6880 | TAF9 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.48e-07 | 2.20e-01 | -0.1088 |
| 6880 | TAF9 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.56e-06 | 1.69e-01 | -0.1954 |
| 6880 | TAF9 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.23e-03 | 1.63e-01 | -0.1526 |
| 6880 | TAF9 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-03 | 1.10e-01 | -0.1464 |
| 6880 | TAF9 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 3.56e-01 | -0.1706 |
| 6880 | TAF9 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.96e-03 | 1.79e-01 | -0.0179 |
| 6880 | TAF9 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.92e-06 | 1.77e-01 | 0.096 |
| 6880 | TAF9 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.31e-01 | 0.0131 |
| 6880 | TAF9 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.04e-05 | 3.17e-01 | -0.0177 |
| 6880 | TAF9 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.19e-07 | 5.97e-01 | 0.0171 |
| 6880 | TAF9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.44e-12 | 2.41e-01 | 0.0674 |
| 6880 | TAF9 | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.71e-07 | 4.93e-01 | -0.0124 |
| 6880 | TAF9 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.92e-06 | 2.06e-01 | 0.0588 |
| 6880 | TAF9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.92e-23 | 4.12e-01 | 0.294 |
| 6880 | TAF9 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.42e-04 | 4.33e-01 | 0.3487 |
| 6880 | TAF9 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.11e-14 | 3.47e-01 | 0.3859 |
| 6880 | TAF9 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.14e-04 | 1.99e-01 | 0.2585 |
| 6880 | TAF9 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.61e-02 | 8.75e-02 | 0.3005 |
| 6880 | TAF9 | LZE4T | Human | Esophagus | ESCC | 2.98e-11 | 3.61e-01 | 0.0811 |
| 6880 | TAF9 | LZE7T | Human | Esophagus | ESCC | 2.45e-02 | 2.94e-01 | 0.0667 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903051 | Colorectum | AD | negative regulation of proteolysis involved in cellular protein catabolic process | 31/3918 | 64/18723 | 8.71e-07 | 2.98e-05 | 31 |
| GO:2000059 | Colorectum | AD | negative regulation of ubiquitin-dependent protein catabolic process | 24/3918 | 48/18723 | 7.38e-06 | 1.81e-04 | 24 |
| GO:0072331 | Colorectum | AD | signal transduction by p53 class mediator | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
| GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
| GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
| GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
| GO:1901799 | Colorectum | AD | negative regulation of proteasomal protein catabolic process | 23/3918 | 49/18723 | 4.18e-05 | 7.37e-04 | 23 |
| GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
| GO:0032435 | Colorectum | AD | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 18/3918 | 35/18723 | 6.33e-05 | 1.05e-03 | 18 |
| GO:1901796 | Colorectum | AD | regulation of signal transduction by p53 class mediator | 36/3918 | 93/18723 | 6.58e-05 | 1.07e-03 | 36 |
| GO:0072332 | Colorectum | AD | intrinsic apoptotic signaling pathway by p53 class mediator | 30/3918 | 76/18723 | 1.72e-04 | 2.33e-03 | 30 |
| GO:1902253 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 15/3918 | 29/18723 | 2.38e-04 | 3.03e-03 | 15 |
| GO:0008630 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to DNA damage | 33/3918 | 99/18723 | 2.71e-03 | 2.05e-02 | 33 |
| GO:00421761 | Colorectum | SER | regulation of protein catabolic process | 126/2897 | 391/18723 | 5.33e-17 | 2.52e-14 | 126 |
| GO:19033621 | Colorectum | SER | regulation of cellular protein catabolic process | 91/2897 | 255/18723 | 1.22e-15 | 5.36e-13 | 91 |
| GO:19030501 | Colorectum | SER | regulation of proteolysis involved in cellular protein catabolic process | 77/2897 | 221/18723 | 7.85e-13 | 2.00e-10 | 77 |
| GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
| GO:20012421 | Colorectum | SER | regulation of intrinsic apoptotic signaling pathway | 59/2897 | 164/18723 | 8.42e-11 | 1.20e-08 | 59 |
| GO:00971931 | Colorectum | SER | intrinsic apoptotic signaling pathway | 87/2897 | 288/18723 | 1.67e-10 | 2.32e-08 | 87 |
| GO:20012331 | Colorectum | SER | regulation of apoptotic signaling pathway | 101/2897 | 356/18723 | 3.05e-10 | 4.07e-08 | 101 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
| hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
| hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
| hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| TAF9 | DC | Cervix | ADJ | AC016831.1,EIF4EBP3,AK6, etc. | 1.67e-01 |  |
| TAF9 | DC | Cervix | N_HPV | AC016831.1,EIF4EBP3,AK6, etc. | 2.03e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TAF9 | SNV | Missense_Mutation | c.238N>T | p.Asp80Tyr | p.D80Y | Q16594 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
| TAF9 | SNV | Missense_Mutation | novel | c.553N>G | p.Gln185Glu | p.Q185E | Q16594 | protein_coding | tolerated(0.11) | possibly_damaging(0.749) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| TAF9 | SNV | Missense_Mutation | c.268N>T | p.Asp90Tyr | p.D90Y | Q16594 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TAF9 | SNV | Missense_Mutation | rs374084798 | c.235N>A | p.Ala79Thr | p.A79T | Q16594 | protein_coding | tolerated(0.42) | benign(0.025) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TAF9 | SNV | Missense_Mutation | novel | c.280N>T | p.Asp94Tyr | p.D94Y | Q16594 | protein_coding | deleterious(0) | possibly_damaging(0.492) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TAF9 | deletion | Frame_Shift_Del | c.275delN | p.Leu92TyrfsTer2 | p.L92Yfs*2 | Q16594 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |||
| TAF9 | SNV | Missense_Mutation | c.266G>T | p.Arg89Ile | p.R89I | Q16594 | protein_coding | deleterious(0) | possibly_damaging(0.588) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
| TAF9 | SNV | Missense_Mutation | c.268N>T | p.Asp90Tyr | p.D90Y | Q16594 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| TAF9 | SNV | Missense_Mutation | c.272N>G | p.Phe91Cys | p.F91C | Q16594 | protein_coding | deleterious(0.01) | probably_damaging(0.926) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| TAF9 | SNV | Missense_Mutation | novel | c.165A>C | p.Lys55Asn | p.K55N | Q16594 | protein_coding | tolerated(0.11) | benign(0.022) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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