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Gene: STC1 |
Gene summary for STC1 |
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Gene information | Species | Human | Gene symbol | STC1 | Gene ID | 6781 |
Gene name | stanniocalcin 1 | |
Gene Alias | STC | |
Cytomap | 8p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P52823 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6781 | STC1 | GSM4909291 | Human | Breast | IDC | 7.08e-12 | 4.35e-01 | 0.1753 |
6781 | STC1 | GSM4909296 | Human | Breast | IDC | 1.57e-03 | -1.37e-01 | 0.1524 |
6781 | STC1 | GSM4909308 | Human | Breast | IDC | 6.60e-14 | 3.30e-01 | 0.158 |
6781 | STC1 | GSM4909319 | Human | Breast | IDC | 1.12e-09 | 1.92e-01 | 0.1563 |
6781 | STC1 | brca1 | Human | Breast | Precancer | 3.51e-04 | -1.34e-01 | -0.0338 |
6781 | STC1 | brca10 | Human | Breast | Precancer | 4.77e-05 | 2.51e-01 | -0.0029 |
6781 | STC1 | DCIS2 | Human | Breast | DCIS | 9.19e-26 | 5.55e-01 | 0.0085 |
6781 | STC1 | LZE8T | Human | Esophagus | ESCC | 2.15e-05 | 5.99e-01 | 0.067 |
6781 | STC1 | LZE6T | Human | Esophagus | ESCC | 2.10e-16 | 7.35e-01 | 0.0845 |
6781 | STC1 | P2T-E | Human | Esophagus | ESCC | 1.14e-08 | 3.62e-01 | 0.1177 |
6781 | STC1 | P4T-E | Human | Esophagus | ESCC | 4.08e-04 | 2.26e-01 | 0.1323 |
6781 | STC1 | P16T-E | Human | Esophagus | ESCC | 7.06e-05 | 2.27e-01 | 0.1153 |
6781 | STC1 | P19T-E | Human | Esophagus | ESCC | 4.19e-02 | 7.63e-01 | 0.1662 |
6781 | STC1 | P26T-E | Human | Esophagus | ESCC | 8.40e-11 | 4.66e-01 | 0.1276 |
6781 | STC1 | P36T-E | Human | Esophagus | ESCC | 1.17e-15 | 2.00e+00 | 0.1187 |
6781 | STC1 | P37T-E | Human | Esophagus | ESCC | 1.13e-13 | 6.07e-01 | 0.1371 |
6781 | STC1 | P56T-E | Human | Esophagus | ESCC | 1.43e-06 | 6.77e-01 | 0.1613 |
6781 | STC1 | P76T-E | Human | Esophagus | ESCC | 8.69e-04 | 4.93e-01 | 0.1207 |
6781 | STC1 | P89T-E | Human | Esophagus | ESCC | 1.03e-10 | 2.42e+00 | 0.1752 |
6781 | STC1 | P107T-E | Human | Esophagus | ESCC | 3.38e-06 | 4.27e-01 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016678 | Breast | Precancer | ameboidal-type cell migration | 47/1080 | 475/18723 | 2.19e-04 | 3.35e-03 | 47 |
GO:00486087 | Breast | Precancer | reproductive structure development | 43/1080 | 424/18723 | 2.36e-04 | 3.56e-03 | 43 |
GO:00614587 | Breast | Precancer | reproductive system development | 43/1080 | 427/18723 | 2.75e-04 | 4.00e-03 | 43 |
GO:00105943 | Breast | Precancer | regulation of endothelial cell migration | 27/1080 | 232/18723 | 4.12e-04 | 5.55e-03 | 27 |
GO:00018907 | Breast | Precancer | placenta development | 19/1080 | 144/18723 | 6.26e-04 | 7.78e-03 | 19 |
GO:00713846 | Breast | Precancer | cellular response to corticosteroid stimulus | 11/1080 | 61/18723 | 6.54e-04 | 8.01e-03 | 11 |
GO:00713856 | Breast | Precancer | cellular response to glucocorticoid stimulus | 10/1080 | 56/18723 | 1.23e-03 | 1.32e-02 | 10 |
GO:00515919 | Breast | Precancer | response to cAMP | 13/1080 | 93/18723 | 2.57e-03 | 2.33e-02 | 13 |
GO:00466839 | Breast | Precancer | response to organophosphorus | 16/1080 | 131/18723 | 3.60e-03 | 2.98e-02 | 16 |
GO:00109596 | Breast | Precancer | regulation of metal ion transport | 37/1080 | 406/18723 | 4.07e-03 | 3.22e-02 | 37 |
GO:00020649 | Breast | Precancer | epithelial cell development | 23/1080 | 220/18723 | 4.28e-03 | 3.35e-02 | 23 |
GO:00140749 | Breast | Precancer | response to purine-containing compound | 17/1080 | 148/18723 | 5.17e-03 | 3.86e-02 | 17 |
GO:00075845 | Breast | Precancer | response to nutrient | 19/1080 | 174/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:00015036 | Breast | Precancer | ossification | 36/1080 | 408/18723 | 7.53e-03 | 4.98e-02 | 36 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
GO:007048214 | Breast | IDC | response to oxygen levels | 64/1434 | 347/18723 | 3.45e-11 | 5.57e-09 | 64 |
GO:003629314 | Breast | IDC | response to decreased oxygen levels | 60/1434 | 322/18723 | 9.26e-11 | 1.25e-08 | 60 |
GO:000166614 | Breast | IDC | response to hypoxia | 58/1434 | 307/18723 | 1.09e-10 | 1.38e-08 | 58 |
GO:003196013 | Breast | IDC | response to corticosteroid | 37/1434 | 167/18723 | 3.10e-09 | 2.63e-07 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STC1 | SNV | Missense_Mutation | c.368A>G | p.Glu123Gly | p.E123G | P52823 | protein_coding | deleterious(0) | possibly_damaging(0.478) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STC1 | SNV | Missense_Mutation | c.299C>T | p.Ala100Val | p.A100V | P52823 | protein_coding | deleterious(0.03) | benign(0.225) | TCGA-S3-A6ZG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
STC1 | SNV | Missense_Mutation | rs758995378 | c.274N>A | p.Val92Ile | p.V92I | P52823 | protein_coding | tolerated(0.58) | probably_damaging(0.988) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
STC1 | SNV | Missense_Mutation | novel | c.441G>T | p.Glu147Asp | p.E147D | P52823 | protein_coding | tolerated(0.07) | probably_damaging(0.992) | TCGA-DS-A3LQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
STC1 | SNV | Missense_Mutation | novel | c.603C>A | p.His201Gln | p.H201Q | P52823 | protein_coding | tolerated(0.33) | benign(0.093) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STC1 | SNV | Missense_Mutation | c.280N>C | p.Glu94Gln | p.E94Q | P52823 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STC1 | SNV | Missense_Mutation | c.284N>A | p.Ser95Asn | p.S95N | P52823 | protein_coding | deleterious(0.03) | benign(0.153) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
STC1 | SNV | Missense_Mutation | rs139152218 | c.445N>A | p.Val149Ile | p.V149I | P52823 | protein_coding | tolerated(0.89) | benign(0.011) | TCGA-CM-6165-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STC1 | SNV | Missense_Mutation | novel | c.497G>A | p.Ser166Asn | p.S166N | P52823 | protein_coding | deleterious(0.04) | possibly_damaging(0.738) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STC1 | SNV | Missense_Mutation | rs765625301 | c.656C>T | p.Pro219Leu | p.P219L | P52823 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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