Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SNRNP70

Gene summary for SNRNP70

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SNRNP70

Gene ID

6625

Gene namesmall nuclear ribonucleoprotein U1 subunit 70
Gene AliasRNPU1Z
Cytomap19q13.33
Gene Typeprotein-coding
GO ID

GO:0000375

UniProtAcc

P08621


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6625SNRNP70HTA11_1938_2000001011HumanColorectumAD1.26e-106.89e-01-0.0811
6625SNRNP70HTA11_347_2000001011HumanColorectumAD1.49e-053.43e-01-0.1954
6625SNRNP70HTA11_3361_2000001011HumanColorectumAD5.64e-044.01e-01-0.1207
6625SNRNP70HTA11_696_2000001011HumanColorectumAD2.89e-055.10e-01-0.1464
6625SNRNP70HTA11_1391_2000001011HumanColorectumAD8.10e-168.59e-01-0.059
6625SNRNP70HTA11_866_3004761011HumanColorectumAD1.32e-085.59e-010.096
6625SNRNP70HTA11_10711_2000001011HumanColorectumAD4.34e-086.19e-010.0338
6625SNRNP70HTA11_7696_3000711011HumanColorectumAD7.21e-217.85e-010.0674
6625SNRNP70HTA11_99999970781_79442HumanColorectumMSS6.29e-054.55e-010.294
6625SNRNP70HTA11_99999965104_69814HumanColorectumMSS2.87e-116.98e-010.281
6625SNRNP70HTA11_99999971662_82457HumanColorectumMSS9.47e-148.84e-010.3859
6625SNRNP70HTA11_99999974143_84620HumanColorectumMSS6.87e-065.31e-010.3005
6625SNRNP70A015-C-203HumanColorectumFAP1.86e-193.97e-01-0.1294
6625SNRNP70A002-C-201HumanColorectumFAP7.19e-071.41e-010.0324
6625SNRNP70A001-C-108HumanColorectumFAP2.78e-03-1.87e-02-0.0272
6625SNRNP70A002-C-205HumanColorectumFAP2.93e-09-7.64e-02-0.1236
6625SNRNP70A015-C-006HumanColorectumFAP9.89e-091.47e-01-0.0994
6625SNRNP70A015-C-106HumanColorectumFAP1.61e-083.62e-01-0.0511
6625SNRNP70A002-C-114HumanColorectumFAP2.90e-104.63e-02-0.1561
6625SNRNP70A015-C-104HumanColorectumFAP2.02e-264.20e-01-0.1899
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00421762ColorectumMSSregulation of protein catabolic process145/3467391/187232.03e-181.17e-15145
GO:19033112ColorectumMSSregulation of mRNA metabolic process115/3467288/187231.23e-176.41e-15115
GO:00003772ColorectumMSSRNA splicing, via transesterification reactions with bulged adenosine as nucleophile121/3467320/187232.52e-168.27e-14121
GO:00003982ColorectumMSSmRNA splicing, via spliceosome121/3467320/187232.52e-168.27e-14121
GO:00003752ColorectumMSSRNA splicing, via transesterification reactions122/3467324/187232.75e-168.58e-14122
GO:00434842ColorectumMSSregulation of RNA splicing66/3467148/187232.44e-135.25e-1166
GO:00313302ColorectumMSSnegative regulation of cellular catabolic process96/3467262/187232.67e-124.63e-1096
GO:00098952ColorectumMSSnegative regulation of catabolic process110/3467320/187237.88e-121.20e-09110
GO:00506842ColorectumMSSregulation of mRNA processing57/3467137/187232.88e-102.68e-0857
GO:00480242ColorectumMSSregulation of mRNA splicing, via spliceosome46/3467101/187234.20e-103.49e-0846
GO:00064572ColorectumMSSprotein folding71/3467212/187231.25e-075.91e-0671
GO:00421772ColorectumMSSnegative regulation of protein catabolic process47/3467121/187231.28e-076.01e-0647
GO:00105062ColorectumMSSregulation of autophagy95/3467317/187234.36e-071.71e-0595
GO:19033131ColorectumMSSpositive regulation of mRNA metabolic process42/3467118/187238.17e-062.06e-0442
GO:00331201ColorectumMSSpositive regulation of RNA splicing17/346737/187231.22e-041.89e-0317
GO:00420262ColorectumMSSprotein refolding11/346723/187231.29e-031.23e-0211
GO:00480261ColorectumMSSpositive regulation of mRNA splicing, via spliceosome10/346722/187233.42e-032.56e-0210
GO:00105071ColorectumMSSnegative regulation of autophagy26/346785/187234.84e-033.38e-0226
GO:19033114ColorectumFAPregulation of mRNA metabolic process97/2622288/187231.35e-174.13e-1497
GO:00421764ColorectumFAPregulation of protein catabolic process106/2622391/187235.00e-123.06e-09106
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa03040ColorectumADSpliceosome73/2092217/84651.73e-039.68e-036.18e-0373
hsa030401ColorectumADSpliceosome73/2092217/84651.73e-039.68e-036.18e-0373
hsa030402ColorectumMSSSpliceosome66/1875217/84652.58e-031.27e-027.81e-0366
hsa030403ColorectumMSSSpliceosome66/1875217/84652.58e-031.27e-027.81e-0366
hsa030409EndometriumAEHSpliceosome54/1197217/84651.47e-051.65e-041.21e-0454
hsa0304014EndometriumAEHSpliceosome54/1197217/84651.47e-051.65e-041.21e-0454
hsa0304024EndometriumEECSpliceosome54/1237217/84653.78e-053.88e-042.89e-0454
hsa0304034EndometriumEECSpliceosome54/1237217/84653.78e-053.88e-042.89e-0454
hsa0304018EsophagusHGINSpliceosome79/1383217/84653.22e-137.00e-125.56e-1279
hsa0304019EsophagusHGINSpliceosome79/1383217/84653.22e-137.00e-125.56e-1279
hsa0304027EsophagusESCCSpliceosome128/4205217/84653.31e-038.79e-034.50e-03128
hsa0304037EsophagusESCCSpliceosome128/4205217/84653.31e-038.79e-034.50e-03128
hsa030407LiverCirrhoticSpliceosome102/2530217/84655.69e-089.47e-075.84e-07102
hsa0304012LiverCirrhoticSpliceosome102/2530217/84655.69e-089.47e-075.84e-07102
hsa0304022LiverHCCSpliceosome122/4020217/84655.55e-031.60e-028.91e-03122
hsa0304032LiverHCCSpliceosome122/4020217/84655.55e-031.60e-028.91e-03122
hsa0304016Oral cavityOSCCSpliceosome123/3704217/84657.21e-052.74e-041.40e-04123
hsa0304017Oral cavityOSCCSpliceosome123/3704217/84657.21e-052.74e-041.40e-04123
hsa0304026Oral cavityLPSpliceosome106/2418217/84651.30e-102.40e-091.55e-09106
hsa0304036Oral cavityLPSpliceosome106/2418217/84651.30e-102.40e-091.55e-09106
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
SNRNP70STMBreastADJDDX17,CDC42EP5,MALAT1, etc.1.20e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SNRNP70LUMPBreastDCISDDX17,CDC42EP5,MALAT1, etc.2.42e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SNRNP70BASBreastIDCDDX17,CDC42EP5,MALAT1, etc.6.15e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SNRNP70SNVMissense_Mutationc.372N>Cp.Glu124Aspp.E124DP08621protein_codingtolerated(0.06)possibly_damaging(0.758)TCGA-BH-A0B8-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
SNRNP70SNVMissense_Mutationnovelc.708N>Ap.Asp236Glup.D236EP08621protein_codingtolerated(0.9)benign(0)TCGA-BH-A0DQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SNRNP70SNVMissense_Mutationnovelc.797C>Tp.Ser266Leup.S266LP08621protein_codingdeleterious(0.01)benign(0.098)TCGA-C5-A3HE-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
SNRNP70SNVMissense_Mutationc.292N>Gp.Gln98Glup.Q98EP08621protein_codingtolerated(0.4)benign(0.001)TCGA-DR-A0ZM-01Cervixcervical & endocervical cancerFemale<65III/IVUnspecificCisplatinSD
SNRNP70SNVMissense_Mutationc.653N>Ap.Arg218Hisp.R218HP08621protein_codingdeleterious(0.02)possibly_damaging(0.744)TCGA-A6-6781-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyoxaliplatinSD
SNRNP70SNVMissense_Mutationc.194A>Gp.Glu65Glyp.E65GP08621protein_codingdeleterious(0)probably_damaging(0.992)TCGA-F4-6854-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SNRNP70SNVMissense_Mutationc.1286N>Tp.Gly429Valp.G429VP08621protein_codingdeleterious_low_confidence(0)probably_damaging(0.998)TCGA-G4-6302-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SNRNP70SNVMissense_Mutationc.141N>Tp.Glu47Aspp.E47DP08621protein_codingtolerated(0.1)benign(0.115)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
SNRNP70SNVMissense_Mutationnovelc.155N>Ap.Arg52Glnp.R52QP08621protein_codingtolerated(0.11)benign(0.094)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
SNRNP70SNVMissense_Mutationnovelc.170N>Ap.Pro57Glnp.P57QP08621protein_codingdeleterious(0.05)possibly_damaging(0.688)TCGA-A5-A2K3-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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