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Gene: SLC39A6 |
Gene summary for SLC39A6 |
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Gene information | Species | Human | Gene symbol | SLC39A6 | Gene ID | 25800 |
Gene name | solute carrier family 39 member 6 | |
Gene Alias | LIV-1 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q13433 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25800 | SLC39A6 | GSM4909282 | Human | Breast | IDC | 6.66e-03 | -3.13e-01 | -0.0288 |
25800 | SLC39A6 | GSM4909285 | Human | Breast | IDC | 2.07e-04 | -6.95e-02 | 0.21 |
25800 | SLC39A6 | GSM4909286 | Human | Breast | IDC | 1.11e-06 | -9.16e-02 | 0.1081 |
25800 | SLC39A6 | GSM4909288 | Human | Breast | IDC | 3.85e-02 | -4.41e-01 | 0.0988 |
25800 | SLC39A6 | GSM4909294 | Human | Breast | IDC | 4.36e-02 | -3.15e-01 | 0.2022 |
25800 | SLC39A6 | GSM4909296 | Human | Breast | IDC | 3.76e-06 | -2.58e-01 | 0.1524 |
25800 | SLC39A6 | GSM4909297 | Human | Breast | IDC | 4.91e-10 | -2.08e-01 | 0.1517 |
25800 | SLC39A6 | GSM4909298 | Human | Breast | IDC | 5.20e-03 | -1.74e-01 | 0.1551 |
25800 | SLC39A6 | GSM4909301 | Human | Breast | IDC | 6.91e-52 | 9.36e-01 | 0.1577 |
25800 | SLC39A6 | GSM4909303 | Human | Breast | IDC | 1.10e-09 | 6.64e-01 | 0.0438 |
25800 | SLC39A6 | GSM4909307 | Human | Breast | IDC | 1.45e-42 | 9.14e-01 | 0.1569 |
25800 | SLC39A6 | GSM4909308 | Human | Breast | IDC | 2.77e-87 | 1.18e+00 | 0.158 |
25800 | SLC39A6 | GSM4909309 | Human | Breast | IDC | 3.05e-04 | 2.86e-01 | 0.0483 |
25800 | SLC39A6 | GSM4909311 | Human | Breast | IDC | 7.04e-22 | -3.32e-01 | 0.1534 |
25800 | SLC39A6 | GSM4909312 | Human | Breast | IDC | 2.02e-04 | -1.17e-01 | 0.1552 |
25800 | SLC39A6 | GSM4909313 | Human | Breast | IDC | 1.10e-15 | 5.94e-01 | 0.0391 |
25800 | SLC39A6 | GSM4909315 | Human | Breast | IDC | 1.83e-09 | -3.51e-01 | 0.21 |
25800 | SLC39A6 | GSM4909319 | Human | Breast | IDC | 1.49e-30 | -2.92e-01 | 0.1563 |
25800 | SLC39A6 | GSM4909321 | Human | Breast | IDC | 2.24e-10 | 3.00e-01 | 0.1559 |
25800 | SLC39A6 | brca1 | Human | Breast | Precancer | 3.24e-06 | -3.35e-01 | -0.0338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00550695 | Oral cavity | OSCC | zinc ion homeostasis | 24/7305 | 40/18723 | 5.76e-03 | 2.22e-02 | 24 |
GO:00068825 | Oral cavity | OSCC | cellular zinc ion homeostasis | 23/7305 | 38/18723 | 5.87e-03 | 2.24e-02 | 23 |
GO:005507616 | Oral cavity | LP | transition metal ion homeostasis | 54/4623 | 138/18723 | 1.19e-04 | 1.40e-03 | 54 |
GO:004691615 | Oral cavity | LP | cellular transition metal ion homeostasis | 46/4623 | 115/18723 | 2.02e-04 | 2.20e-03 | 46 |
GO:00550769 | Prostate | BPH | transition metal ion homeostasis | 43/3107 | 138/18723 | 1.66e-05 | 2.07e-04 | 43 |
GO:00469167 | Prostate | BPH | cellular transition metal ion homeostasis | 35/3107 | 115/18723 | 1.64e-04 | 1.42e-03 | 35 |
GO:005507615 | Prostate | Tumor | transition metal ion homeostasis | 45/3246 | 138/18723 | 9.11e-06 | 1.33e-04 | 45 |
GO:004691614 | Prostate | Tumor | cellular transition metal ion homeostasis | 37/3246 | 115/18723 | 7.56e-05 | 7.88e-04 | 37 |
GO:005507618 | Skin | cSCC | transition metal ion homeostasis | 57/4864 | 138/18723 | 5.96e-05 | 5.86e-04 | 57 |
GO:004691610 | Skin | cSCC | cellular transition metal ion homeostasis | 48/4864 | 115/18723 | 1.63e-04 | 1.43e-03 | 48 |
GO:00068826 | Skin | cSCC | cellular zinc ion homeostasis | 17/4864 | 38/18723 | 9.41e-03 | 4.25e-02 | 17 |
GO:0055076110 | Thyroid | PTC | transition metal ion homeostasis | 62/5968 | 138/18723 | 8.66e-04 | 5.30e-03 | 62 |
GO:005507632 | Thyroid | ATC | transition metal ion homeostasis | 66/6293 | 138/18723 | 3.64e-04 | 2.25e-03 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0501033 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0501043 | Breast | DCIS | Alzheimer disease | 105/846 | 384/8465 | 3.23e-23 | 1.49e-21 | 1.10e-21 | 105 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0501053 | Breast | DCIS | Alzheimer disease | 105/846 | 384/8465 | 3.23e-23 | 1.49e-21 | 1.10e-21 | 105 |
hsa0501226 | Endometrium | AEH | Parkinson disease | 115/1197 | 266/8465 | 6.24e-32 | 1.01e-29 | 7.42e-30 | 115 |
hsa0501020 | Endometrium | AEH | Alzheimer disease | 124/1197 | 384/8465 | 1.20e-20 | 3.91e-19 | 2.86e-19 | 124 |
hsa05012111 | Endometrium | AEH | Parkinson disease | 115/1197 | 266/8465 | 6.24e-32 | 1.01e-29 | 7.42e-30 | 115 |
hsa05010110 | Endometrium | AEH | Alzheimer disease | 124/1197 | 384/8465 | 1.20e-20 | 3.91e-19 | 2.86e-19 | 124 |
hsa0501227 | Endometrium | EEC | Parkinson disease | 117/1237 | 266/8465 | 5.97e-32 | 9.82e-30 | 7.32e-30 | 117 |
hsa0501025 | Endometrium | EEC | Alzheimer disease | 126/1237 | 384/8465 | 2.25e-20 | 7.40e-19 | 5.52e-19 | 126 |
hsa0501236 | Endometrium | EEC | Parkinson disease | 117/1237 | 266/8465 | 5.97e-32 | 9.82e-30 | 7.32e-30 | 117 |
hsa0501035 | Endometrium | EEC | Alzheimer disease | 126/1237 | 384/8465 | 2.25e-20 | 7.40e-19 | 5.52e-19 | 126 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC39A6 | SNV | Missense_Mutation | c.2047G>A | p.Glu683Lys | p.E683K | Q13433 | protein_coding | deleterious(0.04) | benign(0.115) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR | |
SLC39A6 | SNV | Missense_Mutation | novel | c.2061N>A | p.Met687Ile | p.M687I | Q13433 | protein_coding | deleterious(0.05) | possibly_damaging(0.561) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC39A6 | SNV | Missense_Mutation | c.113N>A | p.Pro38Gln | p.P38Q | Q13433 | protein_coding | deleterious(0.02) | benign(0.122) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SLC39A6 | SNV | Missense_Mutation | c.2122G>A | p.Glu708Lys | p.E708K | Q13433 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC39A6 | SNV | Missense_Mutation | c.2047N>C | p.Glu683Gln | p.E683Q | Q13433 | protein_coding | deleterious(0.04) | benign(0.233) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC39A6 | SNV | Missense_Mutation | c.2012N>T | p.Gly671Val | p.G671V | Q13433 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
SLC39A6 | SNV | Missense_Mutation | c.1384N>A | p.Asp462Asn | p.D462N | Q13433 | protein_coding | tolerated(0.1) | benign(0.079) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
SLC39A6 | SNV | Missense_Mutation | c.787N>C | p.Glu263Gln | p.E263Q | Q13433 | protein_coding | tolerated(0.1) | benign(0.038) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
SLC39A6 | SNV | Missense_Mutation | novel | c.353C>T | p.Ser118Leu | p.S118L | Q13433 | protein_coding | tolerated(0.3) | benign(0) | TCGA-ZJ-AAXJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC39A6 | SNV | Missense_Mutation | rs201226313 | c.2254N>T | p.Arg752Cys | p.R752C | Q13433 | protein_coding | deleterious(0.01) | possibly_damaging(0.613) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
25800 | SLC39A6 | TRANSPORTER, ENZYME, DRUGGABLE GENOME, CELL SURFACE | SGN LIV1A |
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