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Gene: SLC35B4 |
Gene summary for SLC35B4 |
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Gene information | Species | Human | Gene symbol | SLC35B4 | Gene ID | 84912 |
Gene name | solute carrier family 35 member B4 | |
Gene Alias | YEA | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q969S0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84912 | SLC35B4 | HCC1_Meng | Human | Liver | HCC | 3.01e-49 | 5.34e-02 | 0.0246 |
84912 | SLC35B4 | HCC2_Meng | Human | Liver | HCC | 1.66e-09 | -1.75e-02 | 0.0107 |
84912 | SLC35B4 | HCC1 | Human | Liver | HCC | 1.64e-02 | 2.21e+00 | 0.5336 |
84912 | SLC35B4 | HCC2 | Human | Liver | HCC | 6.09e-17 | 3.29e+00 | 0.5341 |
84912 | SLC35B4 | HCC5 | Human | Liver | HCC | 1.62e-03 | 2.12e+00 | 0.4932 |
84912 | SLC35B4 | S014 | Human | Liver | HCC | 5.43e-03 | 3.24e-01 | 0.2254 |
84912 | SLC35B4 | S015 | Human | Liver | HCC | 3.73e-05 | 4.30e-01 | 0.2375 |
84912 | SLC35B4 | S016 | Human | Liver | HCC | 4.42e-05 | 3.23e-01 | 0.2243 |
84912 | SLC35B4 | S028 | Human | Liver | HCC | 2.53e-09 | 5.32e-01 | 0.2503 |
84912 | SLC35B4 | S029 | Human | Liver | HCC | 2.37e-02 | 3.58e-01 | 0.2581 |
84912 | SLC35B4 | male-WTA | Human | Thyroid | PTC | 4.50e-05 | 4.80e-02 | 0.1037 |
84912 | SLC35B4 | PTC01 | Human | Thyroid | PTC | 2.74e-05 | 8.45e-02 | 0.1899 |
84912 | SLC35B4 | PTC05 | Human | Thyroid | PTC | 9.52e-04 | 1.83e-01 | 0.2065 |
84912 | SLC35B4 | PTC06 | Human | Thyroid | PTC | 1.97e-05 | 1.35e-01 | 0.2057 |
84912 | SLC35B4 | PTC07 | Human | Thyroid | PTC | 2.88e-06 | 1.37e-01 | 0.2044 |
84912 | SLC35B4 | ATC09 | Human | Thyroid | ATC | 2.26e-06 | 2.17e-01 | 0.2871 |
84912 | SLC35B4 | ATC11 | Human | Thyroid | ATC | 7.49e-03 | 2.68e-01 | 0.3386 |
84912 | SLC35B4 | ATC12 | Human | Thyroid | ATC | 7.47e-18 | 4.24e-01 | 0.34 |
84912 | SLC35B4 | ATC13 | Human | Thyroid | ATC | 2.34e-20 | 3.64e-01 | 0.34 |
84912 | SLC35B4 | ATC1 | Human | Thyroid | ATC | 2.63e-07 | 2.56e-01 | 0.2878 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000600615 | Thyroid | PTC | glucose metabolic process | 90/5968 | 196/18723 | 2.54e-05 | 2.50e-04 | 90 |
GO:00061097 | Thyroid | PTC | regulation of carbohydrate metabolic process | 75/5968 | 178/18723 | 2.44e-03 | 1.27e-02 | 75 |
GO:00463644 | Thyroid | PTC | monosaccharide biosynthetic process | 37/5968 | 82/18723 | 8.07e-03 | 3.40e-02 | 37 |
GO:00109066 | Thyroid | PTC | regulation of glucose metabolic process | 50/5968 | 119/18723 | 1.25e-02 | 4.88e-02 | 50 |
GO:001593122 | Thyroid | ATC | nucleobase-containing compound transport | 122/6293 | 222/18723 | 4.30e-11 | 1.41e-09 | 122 |
GO:001931814 | Thyroid | ATC | hexose metabolic process | 111/6293 | 237/18723 | 1.51e-05 | 1.41e-04 | 111 |
GO:000599615 | Thyroid | ATC | monosaccharide metabolic process | 118/6293 | 257/18723 | 2.56e-05 | 2.20e-04 | 118 |
GO:000600616 | Thyroid | ATC | glucose metabolic process | 93/6293 | 196/18723 | 3.85e-05 | 3.14e-04 | 93 |
GO:000610913 | Thyroid | ATC | regulation of carbohydrate metabolic process | 78/6293 | 178/18723 | 2.81e-03 | 1.28e-02 | 78 |
GO:004636411 | Thyroid | ATC | monosaccharide biosynthetic process | 39/6293 | 82/18723 | 6.04e-03 | 2.42e-02 | 39 |
GO:001090612 | Thyroid | ATC | regulation of glucose metabolic process | 52/6293 | 119/18723 | 1.37e-02 | 4.77e-02 | 52 |
GO:00193194 | Thyroid | ATC | hexose biosynthetic process | 36/6293 | 78/18723 | 1.43e-02 | 4.92e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35B4 | SNV | Missense_Mutation | novel | c.450G>T | p.Glu150Asp | p.E150D | Q969S0 | protein_coding | tolerated(0.27) | benign(0.009) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35B4 | SNV | Missense_Mutation | c.446N>A | p.Ser149Asn | p.S149N | Q969S0 | protein_coding | tolerated(0.36) | benign(0) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC35B4 | SNV | Missense_Mutation | c.740T>C | p.Ile247Thr | p.I247T | Q969S0 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
SLC35B4 | SNV | Missense_Mutation | novel | c.520T>C | p.Ser174Pro | p.S174P | Q969S0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC35B4 | SNV | Missense_Mutation | rs762326247 | c.758N>A | p.Cys253Tyr | p.C253Y | Q969S0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC35B4 | SNV | Missense_Mutation | rs374056103 | c.697G>A | p.Gly233Arg | p.G233R | Q969S0 | protein_coding | deleterious(0.01) | possibly_damaging(0.5) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35B4 | SNV | Missense_Mutation | novel | c.735G>A | p.Met245Ile | p.M245I | Q969S0 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC35B4 | SNV | Missense_Mutation | rs759264873 | c.827G>A | p.Arg276His | p.R276H | Q969S0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SLC35B4 | SNV | Missense_Mutation | novel | c.721T>C | p.Phe241Leu | p.F241L | Q969S0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35B4 | SNV | Missense_Mutation | novel | c.494N>A | p.Gly165Glu | p.G165E | Q969S0 | protein_coding | deleterious(0.04) | benign(0.157) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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