![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC2A13 |
Gene summary for SLC2A13 |
![]() |
Gene information | Species | Human | Gene symbol | SLC2A13 | Gene ID | 114134 |
Gene name | solute carrier family 2 member 13 | |
Gene Alias | HMIT | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q96QE2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114134 | SLC2A13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.98e-36 | -9.98e-01 | 0.0155 |
114134 | SLC2A13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.55e-11 | -7.06e-01 | -0.1808 |
114134 | SLC2A13 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.73e-08 | -1.09e+00 | 0.0216 |
114134 | SLC2A13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.65e-05 | -6.54e-01 | -0.0811 |
114134 | SLC2A13 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.25e-11 | -7.00e-01 | -0.1088 |
114134 | SLC2A13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.21e-08 | -7.76e-01 | -0.1207 |
114134 | SLC2A13 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.92e-07 | -7.51e-01 | -0.1526 |
114134 | SLC2A13 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.26e-30 | -7.66e-01 | -0.1464 |
114134 | SLC2A13 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.42e-24 | -6.87e-01 | -0.1001 |
114134 | SLC2A13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.54e-10 | -7.19e-01 | -0.059 |
114134 | SLC2A13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.32e-03 | -7.29e-01 | -0.1706 |
114134 | SLC2A13 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.13e-04 | -8.70e-01 | -0.2061 |
114134 | SLC2A13 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.13e-03 | -9.23e-01 | -0.1462 |
114134 | SLC2A13 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.16e-04 | -7.53e-01 | -0.0842 |
114134 | SLC2A13 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.41e-03 | -9.95e-01 | -0.00410000000000005 |
114134 | SLC2A13 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.43e-09 | -9.63e-01 | -0.0179 |
114134 | SLC2A13 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.86e-29 | -9.85e-01 | 0.096 |
114134 | SLC2A13 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.88e-04 | -8.93e-01 | 0.0446 |
114134 | SLC2A13 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.00e-03 | -9.63e-01 | 0.0451 |
114134 | SLC2A13 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.72e-07 | -9.23e-01 | 0.0528 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00342508 | Lung | IAC | positive regulation of cellular amide metabolic process | 34/2061 | 162/18723 | 1.55e-04 | 2.82e-03 | 34 |
GO:003425013 | Lung | AIS | positive regulation of cellular amide metabolic process | 31/1849 | 162/18723 | 2.41e-04 | 4.78e-03 | 31 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC2A13 | SNV | Missense_Mutation | c.781G>C | p.Glu261Gln | p.E261Q | Q96QE2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A04U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
SLC2A13 | SNV | Missense_Mutation | c.1078G>A | p.Asp360Asn | p.D360N | Q96QE2 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
SLC2A13 | SNV | Missense_Mutation | novel | c.1125C>G | p.Phe375Leu | p.F375L | Q96QE2 | protein_coding | deleterious(0) | benign(0.348) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
SLC2A13 | SNV | Missense_Mutation | c.1141N>A | p.Gly381Arg | p.G381R | Q96QE2 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC2A13 | SNV | Missense_Mutation | c.1440N>T | p.Trp480Cys | p.W480C | Q96QE2 | protein_coding | tolerated(0.08) | benign(0.023) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC2A13 | SNV | Missense_Mutation | c.1605A>G | p.Ile535Met | p.I535M | Q96QE2 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC2A13 | SNV | Missense_Mutation | c.1679N>T | p.Ser560Leu | p.S560L | Q96QE2 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC2A13 | SNV | Missense_Mutation | c.847N>T | p.Arg283Cys | p.R283C | Q96QE2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SLC2A13 | SNV | Missense_Mutation | novel | c.1180N>G | p.Thr394Ala | p.T394A | Q96QE2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC2A13 | SNV | Missense_Mutation | c.1187N>A | p.Gly396Asp | p.G396D | Q96QE2 | protein_coding | tolerated(0.06) | possibly_damaging(0.88) | TCGA-AA-A01T-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |