Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: SLC16A1

Gene summary for SLC16A1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SLC16A1

Gene ID

6566

Gene namesolute carrier family 16 member 1
Gene AliasHHF7
Cytomap1p13.2
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

A0A024R0H1


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6566SLC16A1HTA11_1938_2000001011HumanColorectumAD4.43e-034.08e-01-0.0811
6566SLC16A1HTA11_83_2000001011HumanColorectumSER1.38e-055.91e-01-0.1526
6566SLC16A1HTA11_99999970781_79442HumanColorectumMSS3.00e-033.07e-010.294
6566SLC16A1HTA11_99999971662_82457HumanColorectumMSS4.32e-105.18e-010.3859
6566SLC16A1A015-C-203HumanColorectumFAP4.90e-03-1.63e-01-0.1294
6566SLC16A1A002-C-205HumanColorectumFAP5.97e-05-1.90e-01-0.1236
6566SLC16A1A015-C-005HumanColorectumFAP5.99e-04-2.04e-01-0.0336
6566SLC16A1A002-C-114HumanColorectumFAP2.07e-04-1.97e-01-0.1561
6566SLC16A1A015-C-104HumanColorectumFAP1.01e-03-1.85e-01-0.1899
6566SLC16A1A002-C-016HumanColorectumFAP3.90e-04-1.43e-010.0521
6566SLC16A1A015-C-002HumanColorectumFAP1.17e-03-2.16e-01-0.0763
6566SLC16A1A002-C-116HumanColorectumFAP3.57e-03-1.48e-01-0.0452
6566SLC16A1A014-C-008HumanColorectumFAP2.33e-04-2.16e-01-0.191
6566SLC16A1A018-E-020HumanColorectumFAP5.75e-05-2.00e-01-0.2034
6566SLC16A1LZE4THumanEsophagusESCC3.98e-102.00e-010.0811
6566SLC16A1LZE5THumanEsophagusESCC2.86e-02-4.75e-010.0514
6566SLC16A1LZE7THumanEsophagusESCC7.73e-11-2.85e-010.0667
6566SLC16A1LZE8THumanEsophagusESCC3.64e-08-5.70e-010.067
6566SLC16A1LZE21D1HumanEsophagusHGIN9.97e-03-5.12e-010.0632
6566SLC16A1LZE22D1HumanEsophagusHGIN3.13e-04-6.05e-010.0595
Page: 1 2 3 4 5 6 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00716921ColorectumSERprotein localization to extracellular region80/2897368/187238.13e-041.01e-0280
GO:00300731ColorectumSERinsulin secretion46/2897195/187231.86e-031.90e-0246
GO:00507961ColorectumSERregulation of insulin secretion40/2897165/187232.10e-032.06e-0240
GO:00425931ColorectumSERglucose homeostasis57/2897258/187232.92e-032.59e-0257
GO:00158331ColorectumSERpeptide transport58/2897264/187233.08e-032.70e-0258
GO:00335001ColorectumSERcarbohydrate homeostasis57/2897259/187233.20e-032.76e-0257
GO:00900871ColorectumSERregulation of peptide transport46/2897202/187233.86e-033.18e-0246
GO:00027911ColorectumSERregulation of peptide secretion45/2897200/187235.35e-034.03e-0245
GO:00902761ColorectumSERregulation of peptide hormone secretion44/2897196/187236.08e-034.42e-0244
GO:00316672ColorectumMSSresponse to nutrient levels125/3467474/187231.24e-052.88e-04125
GO:00335002ColorectumMSScarbohydrate homeostasis76/3467259/187231.37e-053.14e-0476
GO:00507082ColorectumMSSregulation of protein secretion78/3467268/187231.47e-053.33e-0478
GO:00425932ColorectumMSSglucose homeostasis75/3467258/187232.22e-054.69e-0475
GO:00093062ColorectumMSSprotein secretion98/3467359/187232.43e-055.09e-0498
GO:00355922ColorectumMSSestablishment of protein localization to extracellular region98/3467360/187232.75e-055.58e-0498
GO:00716922ColorectumMSSprotein localization to extracellular region99/3467368/187234.17e-057.83e-0499
GO:00507962ColorectumMSSregulation of insulin secretion50/3467165/187231.61e-042.31e-0350
GO:00300732ColorectumMSSinsulin secretion56/3467195/187233.21e-044.18e-0356
GO:00158332ColorectumMSSpeptide transport71/3467264/187234.79e-045.60e-0371
GO:00900872ColorectumMSSregulation of peptide transport55/3467202/187231.44e-031.34e-0255
Page: 1 2 3 4 5 6 7 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SLC16A1SNVMissense_Mutationrs151166713c.1285G>Ap.Val429Ilep.V429IP53985protein_codingtolerated(1)benign(0.012)TCGA-A2-A25E-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanPD
SLC16A1SNVMissense_Mutationnovelc.1007C>Tp.Ser336Phep.S336FP53985protein_codingdeleterious(0)probably_damaging(0.981)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SLC16A1SNVMissense_Mutationc.402G>Tp.Met134Ilep.M134IP53985protein_codingtolerated(0.56)benign(0.013)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SLC16A1SNVMissense_Mutationrs759149434c.256C>Tp.Arg86Cysp.R86CP53985protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SLC16A1SNVMissense_Mutationnovelc.992N>Gp.Tyr331Cysp.Y331CP53985protein_codingdeleterious(0.01)probably_damaging(0.999)TCGA-D8-A13Z-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicineSD
SLC16A1SNVMissense_Mutationc.867N>Cp.Lys289Asnp.K289NP53985protein_codingdeleterious(0)probably_damaging(0.997)TCGA-D8-A27G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SLC16A1SNVMissense_Mutationrs746931470c.1250N>Ap.Gly417Glup.G417EP53985protein_codingdeleterious(0.02)possibly_damaging(0.597)TCGA-E2-A15K-06Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
SLC16A1SNVMissense_Mutationc.81C>Gp.Phe27Leup.F27LP53985protein_codingdeleterious(0.01)probably_damaging(0.995)TCGA-E2-A1IH-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyaromasinSD
SLC16A1insertionFrame_Shift_Insrs606231309c.41dupCp.Asp15ArgfsTer34p.D15Rfs*34P53985protein_codingTCGA-AN-A0FV-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SLC16A1SNVMissense_Mutationnovelc.1499N>Gp.Val500Glyp.V500GP53985protein_codingdeleterious_low_confidence(0)possibly_damaging(0.637)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEBUTYRATE11882670
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMESODIUM BUTYRATE11882670
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEinhibitor404859052
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEinhibitor252827471
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEPMA14525727
6566SLC16A1TRANSPORTER, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOMEinhibitor384403683
Page: 1