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Gene: SHC1 |
Gene summary for SHC1 |
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Gene information | Species | Human | Gene symbol | SHC1 | Gene ID | 6464 |
Gene name | SHC adaptor protein 1 | |
Gene Alias | SHC | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P29353 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6464 | SHC1 | LZE4T | Human | Esophagus | ESCC | 1.68e-16 | 5.59e-01 | 0.0811 |
6464 | SHC1 | LZE7T | Human | Esophagus | ESCC | 7.66e-03 | 3.48e-01 | 0.0667 |
6464 | SHC1 | LZE8T | Human | Esophagus | ESCC | 3.94e-02 | 2.36e-01 | 0.067 |
6464 | SHC1 | LZE20T | Human | Esophagus | ESCC | 4.59e-02 | 9.01e-02 | 0.0662 |
6464 | SHC1 | LZE22T | Human | Esophagus | ESCC | 2.52e-09 | 2.67e-01 | 0.068 |
6464 | SHC1 | LZE24T | Human | Esophagus | ESCC | 2.49e-09 | 2.19e-01 | 0.0596 |
6464 | SHC1 | LZE21T | Human | Esophagus | ESCC | 3.17e-05 | 1.58e-01 | 0.0655 |
6464 | SHC1 | LZE6T | Human | Esophagus | ESCC | 1.89e-08 | 9.17e-01 | 0.0845 |
6464 | SHC1 | P1T-E | Human | Esophagus | ESCC | 3.34e-05 | 4.12e-01 | 0.0875 |
6464 | SHC1 | P2T-E | Human | Esophagus | ESCC | 3.86e-25 | 4.30e-01 | 0.1177 |
6464 | SHC1 | P4T-E | Human | Esophagus | ESCC | 2.61e-14 | 3.09e-01 | 0.1323 |
6464 | SHC1 | P5T-E | Human | Esophagus | ESCC | 2.51e-37 | 8.52e-01 | 0.1327 |
6464 | SHC1 | P8T-E | Human | Esophagus | ESCC | 7.37e-19 | 3.48e-01 | 0.0889 |
6464 | SHC1 | P9T-E | Human | Esophagus | ESCC | 9.63e-16 | 3.94e-01 | 0.1131 |
6464 | SHC1 | P10T-E | Human | Esophagus | ESCC | 3.00e-34 | 8.00e-01 | 0.116 |
6464 | SHC1 | P11T-E | Human | Esophagus | ESCC | 1.48e-20 | 1.12e+00 | 0.1426 |
6464 | SHC1 | P12T-E | Human | Esophagus | ESCC | 7.32e-10 | 1.13e-01 | 0.1122 |
6464 | SHC1 | P15T-E | Human | Esophagus | ESCC | 7.60e-46 | 1.17e+00 | 0.1149 |
6464 | SHC1 | P16T-E | Human | Esophagus | ESCC | 8.11e-23 | 1.47e-01 | 0.1153 |
6464 | SHC1 | P17T-E | Human | Esophagus | ESCC | 1.22e-13 | 8.19e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:00988767 | Cervix | CC | vesicle-mediated transport to the plasma membrane | 34/2311 | 136/18723 | 3.75e-05 | 5.91e-04 | 34 |
GO:00308339 | Cervix | CC | regulation of actin filament polymerization | 40/2311 | 172/18723 | 4.90e-05 | 7.40e-04 | 40 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:003227310 | Cervix | CC | positive regulation of protein polymerization | 33/2311 | 138/18723 | 1.23e-04 | 1.53e-03 | 33 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:00308389 | Cervix | CC | positive regulation of actin filament polymerization | 24/2311 | 99/18723 | 7.93e-04 | 6.99e-03 | 24 |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:00343147 | Cervix | CC | Arp2/3 complex-mediated actin nucleation | 11/2311 | 39/18723 | 6.13e-03 | 3.48e-02 | 11 |
GO:0030198 | Cervix | CC | extracellular matrix organization | 52/2311 | 301/18723 | 7.43e-03 | 3.98e-02 | 52 |
GO:0043062 | Cervix | CC | extracellular structure organization | 52/2311 | 302/18723 | 7.92e-03 | 4.17e-02 | 52 |
GO:0022617 | Cervix | CC | extracellular matrix disassembly | 15/2311 | 63/18723 | 8.52e-03 | 4.40e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0522020 | Esophagus | ESCC | Chronic myeloid leukemia | 61/4205 | 76/8465 | 3.20e-08 | 2.68e-07 | 1.37e-07 | 61 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa0472225 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0152110 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0521417 | Esophagus | ESCC | Glioma | 52/4205 | 75/8465 | 4.20e-04 | 1.45e-03 | 7.43e-04 | 52 |
hsa049268 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
hsa0401218 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa015227 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa05220110 | Esophagus | ESCC | Chronic myeloid leukemia | 61/4205 | 76/8465 | 3.20e-08 | 2.68e-07 | 1.37e-07 | 61 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
hsa04722111 | Esophagus | ESCC | Neurotrophin signaling pathway | 80/4205 | 119/8465 | 7.33e-05 | 3.07e-04 | 1.57e-04 | 80 |
hsa04510111 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa0491014 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0152115 | Esophagus | ESCC | EGFR tyrosine kinase inhibitor resistance | 55/4205 | 79/8465 | 2.44e-04 | 8.78e-04 | 4.50e-04 | 55 |
hsa0521418 | Esophagus | ESCC | Glioma | 52/4205 | 75/8465 | 4.20e-04 | 1.45e-03 | 7.43e-04 | 52 |
hsa0492616 | Esophagus | ESCC | Relaxin signaling pathway | 81/4205 | 129/8465 | 1.72e-03 | 5.09e-03 | 2.61e-03 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SHC1 | SNV | Missense_Mutation | c.556N>G | p.Gln186Glu | p.Q186E | P29353 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SHC1 | SNV | Missense_Mutation | c.1280N>G | p.Ser427Cys | p.S427C | P29353 | protein_coding | tolerated(0.31) | benign(0.01) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SHC1 | SNV | Missense_Mutation | rs780262070 | c.1133G>A | p.Arg378Gln | p.R378Q | P29353 | protein_coding | tolerated(0.61) | benign(0.09) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
SHC1 | SNV | Missense_Mutation | novel | c.1069N>A | p.Glu357Lys | p.E357K | P29353 | protein_coding | tolerated(0.17) | benign(0.408) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SHC1 | SNV | Missense_Mutation | novel | c.880N>C | p.Glu294Gln | p.E294Q | P29353 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SHC1 | SNV | Missense_Mutation | c.456C>A | p.Asn152Lys | p.N152K | P29353 | protein_coding | tolerated(0.08) | benign(0.31) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SHC1 | SNV | Missense_Mutation | c.430N>T | p.Pro144Ser | p.P144S | P29353 | protein_coding | deleterious(0.03) | benign(0.143) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SHC1 | SNV | Missense_Mutation | rs780518716 | c.1745G>A | p.Arg582Gln | p.R582Q | P29353 | protein_coding | deleterious(0.02) | benign(0.422) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
SHC1 | SNV | Missense_Mutation | c.1485C>G | p.Ser495Arg | p.S495R | P29353 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-D5-6533-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | CR | |
SHC1 | SNV | Missense_Mutation | rs116278635 | c.1396N>A | p.Glu466Lys | p.E466K | P29353 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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