Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SENP5_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SENP5_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SENP5_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SENP5_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SENP5_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SENP5_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SENP5 | SNV | Missense_Mutation | novel | c.799N>G | p.Trp267Gly | p.W267G | Q96HI0 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SENP5 | SNV | Missense_Mutation | | c.1205N>C | p.Gln402Pro | p.Q402P | Q96HI0 | protein_coding | tolerated(0.24) | benign(0.026) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SENP5 | SNV | Missense_Mutation | rs369618833 | c.1430N>G | p.Lys477Arg | p.K477R | Q96HI0 | protein_coding | tolerated(0.08) | benign(0.054) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SENP5 | insertion | In_Frame_Ins | novel | c.1244_1245insTATGGAAGCTGA | p.Val415_Ser416insMetGluAlaGlu | p.V415_S416insMEAE | Q96HI0 | protein_coding | | | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
SENP5 | insertion | Frame_Shift_Ins | novel | c.1246_1247insGGGGAAGGGC | p.Ser416TrpfsTer12 | p.S416Wfs*12 | Q96HI0 | protein_coding | | | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
SENP5 | insertion | Frame_Shift_Ins | novel | c.953_954insAGCTCATGCAAGGTTTATCATCCTAA | p.Thr319AlafsTer31 | p.T319Afs*31 | Q96HI0 | protein_coding | | | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
SENP5 | insertion | Nonsense_Mutation | novel | c.657_658insTGCCTCTGCTTCTGAGCCTTTCTGCTTTCTG | p.Asn220CysfsTer5 | p.N220Cfs*5 | Q96HI0 | protein_coding | | | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SENP5 | insertion | Nonsense_Mutation | novel | c.1438_1439insCCTTCCCCAGAACCTAAAGACCCTTCTTGTCGGC | p.Asn480ThrfsTer6 | p.N480Tfs*6 | Q96HI0 | protein_coding | | | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SENP5 | insertion | Frame_Shift_Ins | novel | c.1354_1355insC | p.Ile452ThrfsTer3 | p.I452Tfs*3 | Q96HI0 | protein_coding | | | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |
SENP5 | insertion | In_Frame_Ins | novel | c.1356_1357insCAGAACCAAAAGCAAGGTTTGCAAGCTAAGAAAAGC | p.Ile452_Leu453insGlnAsnGlnLysGlnGlyLeuGlnAlaLysLysSer | p.I452_L453insQNQKQGLQAKKS | Q96HI0 | protein_coding | | | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |