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Gene: SDC1 |
Gene summary for SDC1 |
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Gene information | Species | Human | Gene symbol | SDC1 | Gene ID | 6382 |
Gene name | syndecan 1 | |
Gene Alias | CD138 | |
Cytomap | 2p24.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P18827 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6382 | SDC1 | GSM4909281 | Human | Breast | IDC | 4.25e-12 | 4.54e-01 | 0.21 |
6382 | SDC1 | GSM4909282 | Human | Breast | IDC | 2.37e-02 | 3.09e-01 | -0.0288 |
6382 | SDC1 | GSM4909285 | Human | Breast | IDC | 3.23e-29 | 6.20e-01 | 0.21 |
6382 | SDC1 | GSM4909289 | Human | Breast | IDC | 6.00e-08 | 6.62e-01 | 0.1064 |
6382 | SDC1 | GSM4909290 | Human | Breast | IDC | 2.79e-11 | 3.70e-01 | 0.2096 |
6382 | SDC1 | GSM4909291 | Human | Breast | IDC | 6.71e-18 | 5.57e-01 | 0.1753 |
6382 | SDC1 | GSM4909296 | Human | Breast | IDC | 2.00e-02 | 2.84e-01 | 0.1524 |
6382 | SDC1 | GSM4909297 | Human | Breast | IDC | 8.87e-03 | 1.72e-01 | 0.1517 |
6382 | SDC1 | GSM4909302 | Human | Breast | IDC | 1.41e-12 | 4.25e-01 | 0.1545 |
6382 | SDC1 | GSM4909304 | Human | Breast | IDC | 2.63e-06 | 3.75e-01 | 0.1636 |
6382 | SDC1 | GSM4909305 | Human | Breast | IDC | 2.59e-04 | 2.69e-01 | 0.0436 |
6382 | SDC1 | GSM4909311 | Human | Breast | IDC | 1.40e-02 | 3.21e-03 | 0.1534 |
6382 | SDC1 | GSM4909313 | Human | Breast | IDC | 9.09e-03 | 2.45e-01 | 0.0391 |
6382 | SDC1 | GSM4909317 | Human | Breast | IDC | 6.63e-35 | 7.95e-01 | 0.1355 |
6382 | SDC1 | GSM4909319 | Human | Breast | IDC | 6.66e-06 | -5.13e-02 | 0.1563 |
6382 | SDC1 | brca2 | Human | Breast | Precancer | 3.80e-08 | 3.21e-01 | -0.024 |
6382 | SDC1 | M2 | Human | Breast | IDC | 1.40e-06 | 5.66e-01 | 0.21 |
6382 | SDC1 | DCIS2 | Human | Breast | DCIS | 2.09e-50 | 4.40e-01 | 0.0085 |
6382 | SDC1 | CA_HPV_1 | Human | Cervix | CC | 8.81e-06 | -2.40e-01 | 0.0264 |
6382 | SDC1 | CA_HPV_3 | Human | Cervix | CC | 3.11e-06 | 1.79e-01 | 0.0414 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19901826 | Breast | Precancer | exosomal secretion | 5/1080 | 20/18723 | 4.74e-03 | 3.61e-02 | 5 |
GO:00140749 | Breast | Precancer | response to purine-containing compound | 17/1080 | 148/18723 | 5.17e-03 | 3.86e-02 | 17 |
GO:00720735 | Breast | Precancer | kidney epithelium development | 16/1080 | 136/18723 | 5.21e-03 | 3.88e-02 | 16 |
GO:00977346 | Breast | Precancer | extracellular exosome biogenesis | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:00016572 | Breast | Precancer | ureteric bud development | 12/1080 | 91/18723 | 5.97e-03 | 4.22e-02 | 12 |
GO:00721632 | Breast | Precancer | mesonephric epithelium development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:00721642 | Breast | Precancer | mesonephric tubule development | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
GO:000697914 | Breast | IDC | response to oxidative stress | 83/1434 | 446/18723 | 2.36e-14 | 7.06e-12 | 83 |
GO:001003814 | Breast | IDC | response to metal ion | 65/1434 | 373/18723 | 2.95e-10 | 3.42e-08 | 65 |
GO:000030214 | Breast | IDC | response to reactive oxygen species | 46/1434 | 222/18723 | 4.12e-10 | 4.59e-08 | 46 |
GO:003196013 | Breast | IDC | response to corticosteroid | 37/1434 | 167/18723 | 3.10e-09 | 2.63e-07 | 37 |
GO:004254213 | Breast | IDC | response to hydrogen peroxide | 32/1434 | 146/18723 | 4.65e-08 | 3.02e-06 | 32 |
GO:005138413 | Breast | IDC | response to glucocorticoid | 32/1434 | 148/18723 | 6.52e-08 | 4.07e-06 | 32 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:004860812 | Breast | IDC | reproductive structure development | 60/1434 | 424/18723 | 2.71e-06 | 1.03e-04 | 60 |
GO:006145813 | Breast | IDC | reproductive system development | 60/1434 | 427/18723 | 3.41e-06 | 1.24e-04 | 60 |
GO:005159114 | Breast | IDC | response to cAMP | 20/1434 | 93/18723 | 2.00e-05 | 4.91e-04 | 20 |
GO:004668312 | Breast | IDC | response to organophosphorus | 24/1434 | 131/18723 | 5.22e-05 | 1.12e-03 | 24 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541818 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0520514 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0541819 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0520515 | Breast | Precancer | Proteoglycans in cancer | 30/684 | 205/8465 | 1.00e-03 | 7.18e-03 | 5.50e-03 | 30 |
hsa0541824 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0541834 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0541844 | Breast | DCIS | Fluid shear stress and atherosclerosis | 34/846 | 139/8465 | 5.31e-07 | 9.03e-06 | 6.65e-06 | 34 |
hsa0520542 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0541854 | Breast | DCIS | Fluid shear stress and atherosclerosis | 34/846 | 139/8465 | 5.31e-07 | 9.03e-06 | 6.65e-06 | 34 |
hsa0520552 | Breast | DCIS | Proteoglycans in cancer | 39/846 | 205/8465 | 5.36e-05 | 5.58e-04 | 4.11e-04 | 39 |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa05418110 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451421 | Cervix | HSIL_HPV | Cell adhesion molecules | 20/459 | 157/8465 | 3.03e-04 | 3.06e-03 | 2.47e-03 | 20 |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
COL1A1 | SDC1 | COL1A1_SDC1 | COLLAGEN | Breast | DCIS |
COL1A2 | SDC1 | COL1A2_SDC1 | COLLAGEN | Breast | DCIS |
COL4A1 | SDC1 | COL4A1_SDC1 | COLLAGEN | Breast | DCIS |
COL4A2 | SDC1 | COL4A2_SDC1 | COLLAGEN | Breast | DCIS |
COL6A1 | SDC1 | COL6A1_SDC1 | COLLAGEN | Breast | DCIS |
COL6A2 | SDC1 | COL6A2_SDC1 | COLLAGEN | Breast | DCIS |
COL6A3 | SDC1 | COL6A3_SDC1 | COLLAGEN | Breast | DCIS |
MDK | SDC1 | MDK_SDC1 | MK | Breast | DCIS |
FN1 | SDC1 | FN1_SDC1 | FN1 | Breast | DCIS |
PTN | SDC1 | PTN_SDC1 | PTN | Breast | DCIS |
THBS1 | SDC1 | THBS1_SDC1 | THBS | Breast | DCIS |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | DCIS |
THBS3 | SDC1 | THBS3_SDC1 | THBS | Breast | DCIS |
ANGPTL4 | SDC1 | ANGPTL4_SDC1 | ANGPTL | Breast | DCIS |
TNC | SDC1 | TNC_SDC1 | TENASCIN | Breast | DCIS |
TNXB | SDC1 | TNXB_SDC1 | TENASCIN | Breast | DCIS |
COL1A1 | SDC1 | COL1A1_SDC1 | COLLAGEN | Breast | Healthy |
COL1A2 | SDC1 | COL1A2_SDC1 | COLLAGEN | Breast | Healthy |
COL4A1 | SDC1 | COL4A1_SDC1 | COLLAGEN | Breast | Healthy |
COL4A2 | SDC1 | COL4A2_SDC1 | COLLAGEN | Breast | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDC1 | deletion | Frame_Shift_Del | novel | c.644_647delNNNN | p.Thr215ArgfsTer7 | p.T215Rfs*7 | P18827 | protein_coding | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | ||
SDC1 | SNV | Missense_Mutation | c.491N>G | p.Thr164Ser | p.T164S | P18827 | protein_coding | tolerated(0.39) | possibly_damaging(0.724) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SDC1 | SNV | Missense_Mutation | novel | c.703N>C | p.Val235Leu | p.V235L | P18827 | protein_coding | tolerated(0.15) | benign(0.05) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SDC1 | SNV | Missense_Mutation | rs753254745 | c.847N>A | p.Glu283Lys | p.E283K | P18827 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SDC1 | SNV | Missense_Mutation | c.627N>T | p.Gln209His | p.Q209H | P18827 | protein_coding | tolerated(0.05) | possibly_damaging(0.756) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
SDC1 | SNV | Missense_Mutation | novel | c.103N>A | p.Asp35Asn | p.D35N | P18827 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SDC1 | SNV | Missense_Mutation | novel | c.132N>A | p.Phe44Leu | p.F44L | P18827 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SDC1 | SNV | Missense_Mutation | novel | c.187T>A | p.Ser63Thr | p.S63T | P18827 | protein_coding | tolerated(0.3) | benign(0.187) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SDC1 | SNV | Missense_Mutation | novel | c.97G>T | p.Asp33Tyr | p.D33Y | P18827 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SDC1 | SNV | Missense_Mutation | rs747228317 | c.718N>G | p.Thr240Ala | p.T240A | P18827 | protein_coding | tolerated(0.76) | benign(0.046) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CAR138 T Cells | |||
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CART-138 cells | |||
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CD138 CAR T cells | |||
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | BT-062 | INDATUXIMAB RAVTANSINE | ||
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | HEPARIN | HEPARIN | 11333985 | |
6382 | SDC1 | CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | CAR-T cells targeting CD138 |
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