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Gene: SCAMP2 |
Gene summary for SCAMP2 |
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Gene information | Species | Human | Gene symbol | SCAMP2 | Gene ID | 10066 |
Gene name | secretory carrier membrane protein 2 | |
Gene Alias | SCAMP2 | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A8K769 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10066 | SCAMP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.17e-06 | 3.53e-01 | 0.0155 |
10066 | SCAMP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.45e-30 | 1.19e+00 | -0.1808 |
10066 | SCAMP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.93e-19 | 9.54e-01 | -0.0811 |
10066 | SCAMP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.97e-13 | 7.06e-01 | -0.1088 |
10066 | SCAMP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.64e-53 | 1.27e+00 | -0.1954 |
10066 | SCAMP2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.74e-12 | 1.90e+00 | -0.2602 |
10066 | SCAMP2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.13e-08 | 1.05e+00 | -0.2196 |
10066 | SCAMP2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.14e-19 | 9.02e-01 | -0.1207 |
10066 | SCAMP2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.04e-15 | 8.48e-01 | -0.1526 |
10066 | SCAMP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.40e-44 | 1.17e+00 | -0.1464 |
10066 | SCAMP2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.91e-20 | 8.42e-01 | -0.1001 |
10066 | SCAMP2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.62e-27 | 1.03e+00 | -0.059 |
10066 | SCAMP2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.98e-05 | 8.65e-01 | -0.1706 |
10066 | SCAMP2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.82e-15 | 1.10e+00 | -0.2061 |
10066 | SCAMP2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.61e-13 | 1.09e+00 | -0.1462 |
10066 | SCAMP2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.70e-18 | 1.10e+00 | -0.0842 |
10066 | SCAMP2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.34e-07 | 5.71e-01 | -0.0179 |
10066 | SCAMP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.23e-19 | 6.51e-01 | 0.096 |
10066 | SCAMP2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.55e-02 | 4.98e-01 | 0.0451 |
10066 | SCAMP2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.59e-05 | 6.27e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:000689218 | Thyroid | PTC | post-Golgi vesicle-mediated transport | 66/5968 | 104/18723 | 3.36e-11 | 1.24e-09 | 66 |
GO:0048193111 | Thyroid | ATC | Golgi vesicle transport | 189/6293 | 296/18723 | 9.58e-27 | 5.05e-24 | 189 |
GO:000689219 | Thyroid | ATC | post-Golgi vesicle-mediated transport | 68/6293 | 104/18723 | 3.30e-11 | 1.10e-09 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAMP2 | SNV | Missense_Mutation | novel | c.89C>A | p.Pro30Gln | p.P30Q | O15127 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
SCAMP2 | SNV | Missense_Mutation | c.160C>T | p.Leu54Phe | p.L54F | O15127 | protein_coding | tolerated(0.7) | benign(0.031) | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
SCAMP2 | SNV | Missense_Mutation | novel | c.177G>T | p.Gln59His | p.Q59H | O15127 | protein_coding | deleterious(0.02) | benign(0.043) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | c.836N>T | p.Ser279Leu | p.S279L | O15127 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAMP2 | SNV | Missense_Mutation | novel | c.335N>G | p.Asn112Ser | p.N112S | O15127 | protein_coding | tolerated(1) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | novel | c.560N>T | p.Ser187Phe | p.S187F | O15127 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | novel | c.572N>A | p.Phe191Tyr | p.F191Y | O15127 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | rs746545894 | c.440N>A | p.Arg147Gln | p.R147Q | O15127 | protein_coding | deleterious(0.02) | possibly_damaging(0.487) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | novel | c.560N>T | p.Ser187Phe | p.S187F | O15127 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCAMP2 | SNV | Missense_Mutation | novel | c.861N>A | p.His287Gln | p.H287Q | O15127 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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