Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RYBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RYBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/RYBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RYBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RYBP_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RYBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/RYBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RYBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19033622 | Colorectum | MSS | regulation of cellular protein catabolic process | 99/3467 | 255/18723 | 1.90e-14 | 5.37e-12 | 99 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00313302 | Colorectum | MSS | negative regulation of cellular catabolic process | 96/3467 | 262/18723 | 2.67e-12 | 4.63e-10 | 96 |
GO:00098952 | Colorectum | MSS | negative regulation of catabolic process | 110/3467 | 320/18723 | 7.88e-12 | 1.20e-09 | 110 |
GO:19030502 | Colorectum | MSS | regulation of proteolysis involved in cellular protein catabolic process | 82/3467 | 221/18723 | 4.97e-11 | 5.64e-09 | 82 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:20000582 | Colorectum | MSS | regulation of ubiquitin-dependent protein catabolic process | 61/3467 | 164/18723 | 1.28e-08 | 7.61e-07 | 61 |
GO:00611362 | Colorectum | MSS | regulation of proteasomal protein catabolic process | 67/3467 | 187/18723 | 1.45e-08 | 8.47e-07 | 67 |
GO:19033632 | Colorectum | MSS | negative regulation of cellular protein catabolic process | 34/3467 | 75/18723 | 8.96e-08 | 4.44e-06 | 34 |
GO:00421772 | Colorectum | MSS | negative regulation of protein catabolic process | 47/3467 | 121/18723 | 1.28e-07 | 6.01e-06 | 47 |
GO:00324342 | Colorectum | MSS | regulation of proteasomal ubiquitin-dependent protein catabolic process | 49/3467 | 134/18723 | 6.02e-07 | 2.26e-05 | 49 |
GO:20000592 | Colorectum | MSS | negative regulation of ubiquitin-dependent protein catabolic process | 22/3467 | 48/18723 | 1.33e-05 | 3.07e-04 | 22 |
GO:00458612 | Colorectum | MSS | negative regulation of proteolysis | 97/3467 | 351/18723 | 1.57e-05 | 3.54e-04 | 97 |
GO:19030512 | Colorectum | MSS | negative regulation of proteolysis involved in cellular protein catabolic process | 26/3467 | 64/18723 | 3.19e-05 | 6.30e-04 | 26 |
GO:00324352 | Colorectum | MSS | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 17/3467 | 35/18723 | 5.07e-05 | 9.12e-04 | 17 |
GO:19017992 | Colorectum | MSS | negative regulation of proteasomal protein catabolic process | 19/3467 | 49/18723 | 7.20e-04 | 7.70e-03 | 19 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00335221 | Colorectum | MSS | histone H2A ubiquitination | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
GO:00065131 | Colorectum | MSS | protein monoubiquitination | 21/3467 | 67/18723 | 7.90e-03 | 4.84e-02 | 21 |
GO:0016574 | Colorectum | MSS | histone ubiquitination | 16/3467 | 47/18723 | 8.22e-03 | 4.99e-02 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RYBP | SNV | Missense_Mutation | novel | c.470G>A | p.Val158Ile | p.V158I | Q8N488 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RYBP | SNV | Missense_Mutation | novel | c.247G>C | p.Glu83Asp | p.E83D | Q8N488 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AR-A2LH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
RYBP | insertion | Frame_Shift_Ins | novel | c.459_460insTTCTATTTCATTCTCTTCA | p.Asn155SerfsTer16 | p.N155Sfs*16 | Q8N488 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
RYBP | insertion | Nonsense_Mutation | novel | c.458_459insACATAAAGATAGCTTGAGTAAACT | p.Gly154delinsAspIleLysIleAlaTerValAsnCys | p.G154delinsDIKIA*VNC | Q8N488 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
RYBP | SNV | Missense_Mutation | novel | c.515T>C | p.Ser173Pro | p.S173P | Q8N488 | protein_coding | deleterious(0.05) | benign(0.127) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
RYBP | SNV | Missense_Mutation | | c.407C>T | p.Arg137Trp | p.R137W | Q8N488 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RYBP | SNV | Missense_Mutation | novel | c.570N>T | p.Ser191Leu | p.S191L | Q8N488 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RYBP | SNV | Missense_Mutation | novel | c.282N>C | p.Lys95Thr | p.K95T | Q8N488 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RYBP | SNV | Missense_Mutation | novel | c.132N>A | p.Pro45His | p.P45H | Q8N488 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RYBP | SNV | Missense_Mutation | novel | c.144N>T | p.Ser49Phe | p.S49F | Q8N488 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |