GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00015221 | Esophagus | ESCC | pseudouridine synthesis | 16/8552 | 18/18723 | 1.78e-04 | 1.15e-03 | 16 |
GO:0090646 | Esophagus | ESCC | mitochondrial tRNA processing | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
GO:0000154 | Esophagus | ESCC | rRNA modification | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
GO:00311182 | Esophagus | ESCC | rRNA pseudouridine synthesis | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:000641720 | Oral cavity | OSCC | regulation of translation | 274/7305 | 468/18723 | 4.39e-18 | 4.63e-16 | 274 |
GO:004572719 | Oral cavity | OSCC | positive regulation of translation | 101/7305 | 136/18723 | 5.85e-17 | 4.94e-15 | 101 |
GO:003425019 | Oral cavity | OSCC | positive regulation of cellular amide metabolic process | 115/7305 | 162/18723 | 1.28e-16 | 1.05e-14 | 115 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00094511 | Oral cavity | OSCC | RNA modification | 95/7305 | 167/18723 | 2.05e-06 | 2.62e-05 | 95 |
GO:00064001 | Oral cavity | OSCC | tRNA modification | 53/7305 | 90/18723 | 1.04e-04 | 7.70e-04 | 53 |
GO:00701291 | Oral cavity | OSCC | regulation of mitochondrial translation | 17/7305 | 24/18723 | 1.59e-03 | 7.56e-03 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPUSD4 | SNV | Missense_Mutation | | c.770N>T | p.Ala257Val | p.A257V | Q96CM3 | protein_coding | deleterious(0.05) | possibly_damaging(0.824) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPUSD4 | SNV | Missense_Mutation | rs369015729 | c.694N>A | p.Val232Met | p.V232M | Q96CM3 | protein_coding | tolerated(0.09) | benign(0.177) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
RPUSD4 | SNV | Missense_Mutation | | c.718G>C | p.Ala240Pro | p.A240P | Q96CM3 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-GM-A2DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
RPUSD4 | insertion | Frame_Shift_Ins | novel | c.819_820insGTGGGCACCCTGAAGAAGCTGGGGCTAGAACAGTCGAAGG | p.His274ValfsTer26 | p.H274Vfs*26 | Q96CM3 | protein_coding | | | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RPUSD4 | insertion | Nonsense_Mutation | novel | c.1090_1091insTCATGTCATCTGCTTGTAATTAGTTACCATCTGAGCTTGA | p.Asp364ValfsTer8 | p.D364Vfs*8 | Q96CM3 | protein_coding | | | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
RPUSD4 | SNV | Missense_Mutation | | c.703C>T | p.Arg235Trp | p.R235W | Q96CM3 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPUSD4 | SNV | Missense_Mutation | rs142091462 | c.451C>T | p.Arg151Trp | p.R151W | Q96CM3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RPUSD4 | SNV | Missense_Mutation | rs574615517 | c.598N>A | p.Val200Met | p.V200M | Q96CM3 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPUSD4 | SNV | Missense_Mutation | novel | c.487N>A | p.Ala163Thr | p.A163T | Q96CM3 | protein_coding | deleterious(0.04) | possibly_damaging(0.558) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPUSD4 | SNV | Missense_Mutation | | c.104N>T | p.Ala35Val | p.A35V | Q96CM3 | protein_coding | tolerated(0.09) | benign(0.265) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |