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Gene: RPS6KA1 |
Gene summary for RPS6KA1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RPS6KA1 | Gene ID | 6195 |
Gene name | ribosomal protein S6 kinase A1 | |
Gene Alias | HU-1 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q15418 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6195 | RPS6KA1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.60e-03 | 4.38e-01 | -0.1808 |
6195 | RPS6KA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.67e-12 | 4.34e-01 | -0.1954 |
6195 | RPS6KA1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.54e-05 | 8.47e-01 | -0.2196 |
6195 | RPS6KA1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.20e-03 | 4.04e-01 | -0.1207 |
6195 | RPS6KA1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.79e-04 | 3.31e-01 | -0.1526 |
6195 | RPS6KA1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.41e-04 | 4.25e-01 | -0.1464 |
6195 | RPS6KA1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.96e-04 | 3.66e-01 | -0.1001 |
6195 | RPS6KA1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.42e-07 | 6.00e-01 | -0.059 |
6195 | RPS6KA1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.97e-02 | 4.67e-01 | -0.1706 |
6195 | RPS6KA1 | A015-C-203 | Human | Colorectum | FAP | 8.53e-07 | -4.26e-02 | -0.1294 |
6195 | RPS6KA1 | A001-C-108 | Human | Colorectum | FAP | 7.06e-03 | -8.09e-02 | -0.0272 |
6195 | RPS6KA1 | A002-C-205 | Human | Colorectum | FAP | 4.50e-04 | -1.97e-01 | -0.1236 |
6195 | RPS6KA1 | A015-C-104 | Human | Colorectum | FAP | 8.30e-08 | -6.52e-02 | -0.1899 |
6195 | RPS6KA1 | A001-C-014 | Human | Colorectum | FAP | 6.85e-03 | -8.23e-02 | 0.0135 |
6195 | RPS6KA1 | A002-C-016 | Human | Colorectum | FAP | 6.74e-06 | -1.31e-01 | 0.0521 |
6195 | RPS6KA1 | A002-C-116 | Human | Colorectum | FAP | 3.21e-09 | -1.99e-01 | -0.0452 |
6195 | RPS6KA1 | A018-E-020 | Human | Colorectum | FAP | 8.93e-03 | -4.09e-02 | -0.2034 |
6195 | RPS6KA1 | F034 | Human | Colorectum | FAP | 6.15e-05 | -1.31e-01 | -0.0665 |
6195 | RPS6KA1 | CRC-1-8810 | Human | Colorectum | CRC | 1.74e-04 | -1.95e-01 | 0.6257 |
6195 | RPS6KA1 | CRC-3-11773 | Human | Colorectum | CRC | 4.34e-04 | -9.93e-02 | 0.2564 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487321 | Colorectum | SER | gland development | 112/2897 | 436/18723 | 1.75e-08 | 1.28e-06 | 112 |
GO:00525471 | Colorectum | SER | regulation of peptidase activity | 114/2897 | 461/18723 | 1.18e-07 | 7.17e-06 | 114 |
GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
GO:00525481 | Colorectum | SER | regulation of endopeptidase activity | 103/2897 | 432/18723 | 2.86e-06 | 1.16e-04 | 103 |
GO:00610081 | Colorectum | SER | hepaticobiliary system development | 45/2897 | 150/18723 | 4.98e-06 | 1.85e-04 | 45 |
GO:00018891 | Colorectum | SER | liver development | 44/2897 | 147/18723 | 6.73e-06 | 2.35e-04 | 44 |
GO:00432811 | Colorectum | SER | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 57/2897 | 209/18723 | 8.08e-06 | 2.74e-04 | 57 |
GO:20001161 | Colorectum | SER | regulation of cysteine-type endopeptidase activity | 62/2897 | 235/18723 | 1.05e-05 | 3.39e-04 | 62 |
GO:00064171 | Colorectum | SER | regulation of translation | 100/2897 | 468/18723 | 3.76e-04 | 5.74e-03 | 100 |
GO:00015581 | Colorectum | SER | regulation of cell growth | 90/2897 | 414/18723 | 4.00e-04 | 6.02e-03 | 90 |
GO:00431541 | Colorectum | SER | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/2897 | 78/18723 | 5.04e-04 | 7.16e-03 | 24 |
GO:0051346 | Colorectum | SER | negative regulation of hydrolase activity | 82/2897 | 379/18723 | 8.19e-04 | 1.01e-02 | 82 |
GO:20001171 | Colorectum | SER | negative regulation of cysteine-type endopeptidase activity | 25/2897 | 86/18723 | 9.88e-04 | 1.17e-02 | 25 |
GO:00160491 | Colorectum | SER | cell growth | 100/2897 | 482/18723 | 1.07e-03 | 1.24e-02 | 100 |
GO:00436201 | Colorectum | SER | regulation of DNA-templated transcription in response to stress | 17/2897 | 53/18723 | 1.93e-03 | 1.94e-02 | 17 |
GO:0010466 | Colorectum | SER | negative regulation of peptidase activity | 57/2897 | 262/18723 | 4.15e-03 | 3.38e-02 | 57 |
GO:00303071 | Colorectum | SER | positive regulation of cell growth | 39/2897 | 166/18723 | 4.25e-03 | 3.45e-02 | 39 |
GO:00459271 | Colorectum | SER | positive regulation of growth | 56/2897 | 259/18723 | 5.10e-03 | 3.91e-02 | 56 |
GO:00181051 | Colorectum | SER | peptidyl-serine phosphorylation | 66/2897 | 315/18723 | 5.47e-03 | 4.06e-02 | 66 |
GO:00226121 | Colorectum | SER | gland morphogenesis | 29/2897 | 118/18723 | 6.54e-03 | 4.68e-02 | 29 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04714 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04722 | Colorectum | AD | Neurotrophin signaling pathway | 50/2092 | 119/8465 | 2.28e-05 | 2.24e-04 | 1.43e-04 | 50 |
hsa047141 | Colorectum | AD | Thermogenesis | 120/2092 | 232/8465 | 2.76e-19 | 1.16e-17 | 7.37e-18 | 120 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa047221 | Colorectum | AD | Neurotrophin signaling pathway | 50/2092 | 119/8465 | 2.28e-05 | 2.24e-04 | 1.43e-04 | 50 |
hsa047142 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa047222 | Colorectum | SER | Neurotrophin signaling pathway | 35/1580 | 119/8465 | 2.80e-03 | 2.02e-02 | 1.47e-02 | 35 |
hsa047202 | Colorectum | SER | Long-term potentiation | 21/1580 | 67/8465 | 8.52e-03 | 4.26e-02 | 3.09e-02 | 21 |
hsa047143 | Colorectum | SER | Thermogenesis | 106/1580 | 232/8465 | 1.15e-21 | 6.34e-20 | 4.61e-20 | 106 |
hsa051353 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa047223 | Colorectum | SER | Neurotrophin signaling pathway | 35/1580 | 119/8465 | 2.80e-03 | 2.02e-02 | 1.47e-02 | 35 |
hsa047203 | Colorectum | SER | Long-term potentiation | 21/1580 | 67/8465 | 8.52e-03 | 4.26e-02 | 3.09e-02 | 21 |
hsa047148 | Colorectum | FAP | Thermogenesis | 70/1404 | 232/8465 | 1.38e-07 | 3.08e-06 | 1.87e-06 | 70 |
hsa051356 | Colorectum | FAP | Yersinia infection | 43/1404 | 137/8465 | 1.21e-05 | 1.62e-04 | 9.86e-05 | 43 |
hsa047226 | Colorectum | FAP | Neurotrophin signaling pathway | 38/1404 | 119/8465 | 2.49e-05 | 2.78e-04 | 1.69e-04 | 38 |
hsa049312 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa04010 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa047206 | Colorectum | FAP | Long-term potentiation | 20/1404 | 67/8465 | 4.82e-03 | 1.91e-02 | 1.16e-02 | 20 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS6KA1 | SNV | Missense_Mutation | novel | c.107G>T | p.Gly36Val | p.G36V | Q15418 | protein_coding | tolerated(0.19) | benign(0.015) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RPS6KA1 | SNV | Missense_Mutation | novel | c.732C>A | p.Asn244Lys | p.N244K | Q15418 | protein_coding | tolerated(0.11) | benign(0.113) | TCGA-A8-A082-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RPS6KA1 | SNV | Missense_Mutation | rs768720668 | c.1195N>A | p.Asp399Asn | p.D399N | Q15418 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |
RPS6KA1 | SNV | Missense_Mutation | c.908N>A | p.Arg303Gln | p.R303Q | Q15418 | protein_coding | tolerated(0.17) | benign(0.179) | TCGA-EW-A1IY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
RPS6KA1 | SNV | Missense_Mutation | rs766116930 | c.1397N>T | p.Ser466Leu | p.S466L | Q15418 | protein_coding | deleterious(0.01) | benign(0.199) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
RPS6KA1 | insertion | Frame_Shift_Ins | novel | c.988_989insGTTTC | p.Tyr330CysfsTer68 | p.Y330Cfs*68 | Q15418 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
RPS6KA1 | insertion | Nonsense_Mutation | novel | c.989_990insGGGCGAAGCTAGGCATGCCCCAGTTT | p.Tyr330Ter | p.Y330* | Q15418 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
RPS6KA1 | SNV | Missense_Mutation | novel | c.154G>A | p.Glu52Lys | p.E52K | Q15418 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPS6KA1 | SNV | Missense_Mutation | rs779751417 | c.1207N>T | p.Arg403Cys | p.R403C | Q15418 | protein_coding | tolerated(0.06) | benign(0) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPS6KA1 | SNV | Missense_Mutation | novel | c.1016N>G | p.Tyr339Cys | p.Y339C | Q15418 | protein_coding | tolerated(0.06) | benign(0.054) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | 1,6-diazanaphthalenes and pyrido[2,3-d] pyrimidine derivative 1 | |||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 385612197 | ||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | 1,6-diazanaphthalenes and pyrido[2,3-d] pyrimidine derivative 2 | |||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 249565718 | CHEMBL573107 | |
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 178101606 | DORSOMORPHIN | |
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | 249565843 | ||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | Pyrrolo[2,3-d]pyrimidine derivative 2 | |||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BI-D1870 | CHEMBL573107 | ||
6195 | RPS6KA1 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | Pyrrolo[2,3-d]pyrimidine derivative 1 |
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