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Gene: RPRD1A |
Gene summary for RPRD1A |
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Gene information | Species | Human | Gene symbol | RPRD1A | Gene ID | 55197 |
Gene name | regulation of nuclear pre-mRNA domain containing 1A | |
Gene Alias | HsT3101 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96P16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55197 | RPRD1A | CCI_2 | Human | Cervix | CC | 1.09e-04 | 7.23e-01 | 0.5249 |
55197 | RPRD1A | CCI_3 | Human | Cervix | CC | 4.86e-03 | 6.07e-01 | 0.516 |
55197 | RPRD1A | LZE2T | Human | Esophagus | ESCC | 1.69e-02 | 2.96e-01 | 0.082 |
55197 | RPRD1A | LZE4T | Human | Esophagus | ESCC | 7.74e-10 | 2.44e-01 | 0.0811 |
55197 | RPRD1A | LZE7T | Human | Esophagus | ESCC | 1.71e-13 | 6.68e-01 | 0.0667 |
55197 | RPRD1A | LZE8T | Human | Esophagus | ESCC | 7.56e-05 | 3.72e-02 | 0.067 |
55197 | RPRD1A | LZE24T | Human | Esophagus | ESCC | 5.37e-11 | 2.48e-01 | 0.0596 |
55197 | RPRD1A | LZE21T | Human | Esophagus | ESCC | 9.49e-03 | 1.58e-01 | 0.0655 |
55197 | RPRD1A | P1T-E | Human | Esophagus | ESCC | 1.08e-09 | 4.52e-01 | 0.0875 |
55197 | RPRD1A | P2T-E | Human | Esophagus | ESCC | 5.50e-26 | 5.21e-01 | 0.1177 |
55197 | RPRD1A | P4T-E | Human | Esophagus | ESCC | 6.92e-30 | 4.96e-01 | 0.1323 |
55197 | RPRD1A | P5T-E | Human | Esophagus | ESCC | 2.81e-21 | 1.69e-01 | 0.1327 |
55197 | RPRD1A | P8T-E | Human | Esophagus | ESCC | 1.24e-23 | 3.47e-01 | 0.0889 |
55197 | RPRD1A | P9T-E | Human | Esophagus | ESCC | 1.07e-34 | 6.68e-01 | 0.1131 |
55197 | RPRD1A | P10T-E | Human | Esophagus | ESCC | 7.93e-38 | 6.26e-01 | 0.116 |
55197 | RPRD1A | P11T-E | Human | Esophagus | ESCC | 7.82e-08 | 1.04e-01 | 0.1426 |
55197 | RPRD1A | P12T-E | Human | Esophagus | ESCC | 4.08e-19 | 3.29e-01 | 0.1122 |
55197 | RPRD1A | P15T-E | Human | Esophagus | ESCC | 1.78e-14 | 2.96e-01 | 0.1149 |
55197 | RPRD1A | P16T-E | Human | Esophagus | ESCC | 3.96e-27 | 3.03e-01 | 0.1153 |
55197 | RPRD1A | P17T-E | Human | Esophagus | ESCC | 1.06e-11 | 4.03e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:000647020 | Thyroid | PTC | protein dephosphorylation | 123/5968 | 281/18723 | 1.69e-05 | 1.77e-04 | 123 |
GO:003112312 | Thyroid | ATC | RNA 3'-end processing | 65/6293 | 116/18723 | 5.58e-07 | 7.93e-06 | 65 |
GO:003112413 | Thyroid | ATC | mRNA 3'-end processing | 40/6293 | 62/18723 | 6.25e-07 | 8.65e-06 | 40 |
GO:0006470111 | Thyroid | ATC | protein dephosphorylation | 129/6293 | 281/18723 | 1.11e-05 | 1.09e-04 | 129 |
GO:001631117 | Thyroid | ATC | dephosphorylation | 179/6293 | 417/18723 | 3.88e-05 | 3.15e-04 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPRD1A | SNV | Missense_Mutation | novel | c.894N>G | p.Ser298Arg | p.S298R | Q96P16 | protein_coding | deleterious(0) | possibly_damaging(0.514) | TCGA-E2-A1B4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD |
RPRD1A | SNV | Missense_Mutation | rs754314786 | c.656C>T | p.Ala219Val | p.A219V | Q96P16 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
RPRD1A | SNV | Missense_Mutation | novel | c.634C>T | p.Leu212Phe | p.L212F | Q96P16 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-EX-A8YF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RPRD1A | SNV | Missense_Mutation | c.826N>T | p.Arg276Cys | p.R276C | Q96P16 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RPRD1A | SNV | Missense_Mutation | novel | c.156N>C | p.Lys52Asn | p.K52N | Q96P16 | protein_coding | tolerated(0.09) | benign(0.058) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPRD1A | SNV | Missense_Mutation | rs781199117 | c.358G>A | p.Asp120Asn | p.D120N | Q96P16 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AG-3725-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPRD1A | SNV | Missense_Mutation | novel | c.869C>A | p.Ser290Tyr | p.S290Y | Q96P16 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPRD1A | SNV | Missense_Mutation | rs752379681 | c.914C>T | p.Ala305Val | p.A305V | Q96P16 | protein_coding | deleterious(0) | benign(0.228) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RPRD1A | SNV | Missense_Mutation | novel | c.472N>C | p.Ser158Arg | p.S158R | Q96P16 | protein_coding | tolerated(0.57) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPRD1A | SNV | Missense_Mutation | novel | c.777N>T | p.Glu259Asp | p.E259D | Q96P16 | protein_coding | deleterious(0.02) | possibly_damaging(0.566) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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