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Gene: RPP14 |
Gene summary for RPP14 |
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Gene information | Species | Human | Gene symbol | RPP14 | Gene ID | 11102 |
Gene name | ribonuclease P/MRP subunit p14 | |
Gene Alias | P14 | |
Cytomap | 3p14.3 | |
Gene Type | protein-coding | GO ID | GO:0000966 | UniProtAcc | O95059 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11102 | RPP14 | HCC1_Meng | Human | Liver | HCC | 1.81e-43 | 4.80e-02 | 0.0246 |
11102 | RPP14 | HCC1 | Human | Liver | HCC | 5.24e-23 | 3.62e+00 | 0.5336 |
11102 | RPP14 | HCC2 | Human | Liver | HCC | 4.55e-44 | 3.87e+00 | 0.5341 |
11102 | RPP14 | HCC5 | Human | Liver | HCC | 1.07e-46 | 2.56e+00 | 0.4932 |
11102 | RPP14 | Pt13.b | Human | Liver | HCC | 1.91e-03 | 8.58e-02 | 0.0251 |
11102 | RPP14 | Pt14.b | Human | Liver | HCC | 3.71e-02 | 2.26e-01 | 0.018 |
11102 | RPP14 | S014 | Human | Liver | HCC | 2.83e-09 | 3.54e-01 | 0.2254 |
11102 | RPP14 | S015 | Human | Liver | HCC | 4.79e-11 | 4.64e-01 | 0.2375 |
11102 | RPP14 | S016 | Human | Liver | HCC | 2.35e-16 | 5.43e-01 | 0.2243 |
11102 | RPP14 | S027 | Human | Liver | HCC | 1.09e-03 | 5.09e-01 | 0.2446 |
11102 | RPP14 | S028 | Human | Liver | HCC | 1.08e-23 | 9.69e-01 | 0.2503 |
11102 | RPP14 | S029 | Human | Liver | HCC | 6.60e-17 | 7.28e-01 | 0.2581 |
11102 | RPP14 | P1_cSCC | Human | Skin | cSCC | 1.41e-17 | 6.25e-01 | 0.0292 |
11102 | RPP14 | P2_cSCC | Human | Skin | cSCC | 1.00e-11 | 4.06e-01 | -0.024 |
11102 | RPP14 | P4_cSCC | Human | Skin | cSCC | 8.75e-17 | 3.66e-01 | -0.00290000000000005 |
11102 | RPP14 | P10_cSCC | Human | Skin | cSCC | 2.08e-11 | 4.24e-01 | 0.1017 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905024 | Skin | cSCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 34/4864 | 82/18723 | 1.58e-03 | 9.75e-03 | 34 |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPP14 | SNV | Missense_Mutation | rs773275466 | c.137C>T | p.Ser46Leu | p.S46L | O95059 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPP14 | SNV | Missense_Mutation | c.331N>A | p.Leu111Ile | p.L111I | O95059 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RPP14 | SNV | Missense_Mutation | c.331N>A | p.Leu111Ile | p.L111I | O95059 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPP14 | SNV | Missense_Mutation | novel | c.155N>C | p.Phe52Ser | p.F52S | O95059 | protein_coding | deleterious(0.01) | possibly_damaging(0.598) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPP14 | SNV | Missense_Mutation | novel | c.173N>T | p.Ala58Val | p.A58V | O95059 | protein_coding | tolerated(0.05) | probably_damaging(0.947) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RPP14 | SNV | Missense_Mutation | c.29G>T | p.Arg10Ile | p.R10I | O95059 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
RPP14 | SNV | Missense_Mutation | novel | c.136N>C | p.Ser46Pro | p.S46P | O95059 | protein_coding | tolerated(0.12) | possibly_damaging(0.691) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPP14 | insertion | In_Frame_Ins | novel | c.246_247insCTCTTCATA | p.Leu82_Val83insLeuPheIle | p.L82_V83insLFI | O95059 | protein_coding | TCGA-AX-A06B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RPP14 | insertion | In_Frame_Ins | novel | c.337_338insTCACTAATTGTCCAACATGTTTTCCTACTA | p.Ala113delinsValThrAsnCysProThrCysPheProThrThr | p.A113delinsVTNCPTCFPTT | O95059 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
RPP14 | SNV | Missense_Mutation | c.30N>C | p.Arg10Ser | p.R10S | O95059 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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