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Gene: RAP2A |
Gene summary for RAP2A |
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Gene information | Species | Human | Gene symbol | RAP2A | Gene ID | 5911 |
Gene name | RAP2A, member of RAS oncogene family | |
Gene Alias | K-REV | |
Cytomap | 13q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P10114 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5911 | RAP2A | P2T-E | Human | Esophagus | ESCC | 1.45e-20 | 4.33e-02 | 0.1177 |
5911 | RAP2A | P4T-E | Human | Esophagus | ESCC | 2.87e-08 | 1.17e-01 | 0.1323 |
5911 | RAP2A | P5T-E | Human | Esophagus | ESCC | 1.80e-06 | 4.75e-03 | 0.1327 |
5911 | RAP2A | P8T-E | Human | Esophagus | ESCC | 4.22e-03 | 9.76e-03 | 0.0889 |
5911 | RAP2A | P9T-E | Human | Esophagus | ESCC | 2.56e-06 | 3.69e-02 | 0.1131 |
5911 | RAP2A | P10T-E | Human | Esophagus | ESCC | 1.09e-08 | 9.12e-02 | 0.116 |
5911 | RAP2A | P11T-E | Human | Esophagus | ESCC | 1.75e-03 | 9.55e-02 | 0.1426 |
5911 | RAP2A | P12T-E | Human | Esophagus | ESCC | 1.44e-08 | 6.95e-02 | 0.1122 |
5911 | RAP2A | P15T-E | Human | Esophagus | ESCC | 1.67e-06 | 2.25e-02 | 0.1149 |
5911 | RAP2A | P16T-E | Human | Esophagus | ESCC | 6.52e-19 | 3.56e-01 | 0.1153 |
5911 | RAP2A | P21T-E | Human | Esophagus | ESCC | 1.27e-06 | 3.41e-02 | 0.1617 |
5911 | RAP2A | P22T-E | Human | Esophagus | ESCC | 2.01e-02 | -1.41e-02 | 0.1236 |
5911 | RAP2A | P24T-E | Human | Esophagus | ESCC | 2.10e-09 | 1.07e-02 | 0.1287 |
5911 | RAP2A | P26T-E | Human | Esophagus | ESCC | 1.04e-07 | 3.54e-03 | 0.1276 |
5911 | RAP2A | P30T-E | Human | Esophagus | ESCC | 6.70e-08 | 1.17e-01 | 0.137 |
5911 | RAP2A | P31T-E | Human | Esophagus | ESCC | 1.76e-08 | 8.04e-03 | 0.1251 |
5911 | RAP2A | P32T-E | Human | Esophagus | ESCC | 1.45e-12 | 9.12e-02 | 0.1666 |
5911 | RAP2A | P37T-E | Human | Esophagus | ESCC | 1.23e-09 | 9.17e-02 | 0.1371 |
5911 | RAP2A | P39T-E | Human | Esophagus | ESCC | 2.29e-04 | -3.97e-02 | 0.0894 |
5911 | RAP2A | P47T-E | Human | Esophagus | ESCC | 4.57e-16 | -2.97e-04 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:00467775 | Liver | HCC | protein autophosphorylation | 123/7958 | 227/18723 | 2.40e-04 | 1.80e-03 | 123 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:00325286 | Liver | HCC | microvillus organization | 18/7958 | 24/18723 | 1.27e-03 | 6.92e-03 | 18 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
GO:00714662 | Liver | HCC | cellular response to xenobiotic stimulus | 93/7958 | 177/18723 | 4.35e-03 | 1.89e-02 | 93 |
GO:003153212 | Liver | HCC | actin cytoskeleton reorganization | 59/7958 | 107/18723 | 5.57e-03 | 2.32e-02 | 59 |
GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
GO:007265918 | Oral cavity | OSCC | protein localization to plasma membrane | 169/7305 | 284/18723 | 1.69e-12 | 7.21e-11 | 169 |
GO:199077816 | Oral cavity | OSCC | protein localization to cell periphery | 190/7305 | 333/18723 | 1.46e-11 | 5.13e-10 | 190 |
GO:00072659 | Oral cavity | OSCC | Ras protein signal transduction | 185/7305 | 337/18723 | 1.95e-09 | 4.60e-08 | 185 |
GO:003109816 | Oral cavity | OSCC | stress-activated protein kinase signaling cascade | 141/7305 | 247/18723 | 5.74e-09 | 1.25e-07 | 141 |
GO:005140316 | Oral cavity | OSCC | stress-activated MAPK cascade | 134/7305 | 239/18723 | 6.02e-08 | 1.09e-06 | 134 |
GO:007030210 | Oral cavity | OSCC | regulation of stress-activated protein kinase signaling cascade | 111/7305 | 195/18723 | 2.82e-07 | 4.34e-06 | 111 |
GO:003287210 | Oral cavity | OSCC | regulation of stress-activated MAPK cascade | 108/7305 | 192/18723 | 8.97e-07 | 1.22e-05 | 108 |
GO:00467779 | Oral cavity | OSCC | protein autophosphorylation | 123/7305 | 227/18723 | 2.31e-06 | 2.93e-05 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAP2A | SNV | Missense_Mutation | novel | c.463G>A | p.Glu155Lys | p.E155K | P10114 | protein_coding | deleterious(0.02) | benign(0.111) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAP2A | SNV | Missense_Mutation | c.503N>T | p.Ala168Val | p.A168V | P10114 | protein_coding | tolerated(0.17) | benign(0.017) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAP2A | SNV | Missense_Mutation | novel | c.507N>T | p.Gln169His | p.Q169H | P10114 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAP2A | SNV | Missense_Mutation | c.429N>T | p.Met143Ile | p.M143I | P10114 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
RAP2A | SNV | Missense_Mutation | c.439N>A | p.Ala147Thr | p.A147T | P10114 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
RAP2A | SNV | Missense_Mutation | novel | c.463G>A | p.Glu155Lys | p.E155K | P10114 | protein_coding | deleterious(0.02) | benign(0.111) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAP2A | SNV | Missense_Mutation | novel | c.463N>A | p.Glu155Lys | p.E155K | P10114 | protein_coding | deleterious(0.02) | benign(0.111) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAP2A | insertion | Nonsense_Mutation | novel | c.505_506insTCACAGTGGATGATAAAATGAGTTTTATGAAATGATGTTTT | p.Gln169LeufsTer12 | p.Q169Lfs*12 | P10114 | protein_coding | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RAP2A | SNV | Missense_Mutation | c.429N>T | p.Met143Ile | p.M143I | P10114 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RAP2A | SNV | Missense_Mutation | novel | c.490A>T | p.Met164Leu | p.M164L | P10114 | protein_coding | deleterious(0.01) | benign(0.009) | TCGA-55-6975-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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