Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/RAP1GDS1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/RAP1GDS1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/RAP1GDS1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RAP1GDS1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RAP1GDS1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RAP1GDS1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RAP1GDS1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00030122 | Colorectum | FAP | muscle system process | 89/2622 | 452/18723 | 4.63e-04 | 5.39e-03 | 89 |
GO:0003018 | Colorectum | FAP | vascular process in circulatory system | 56/2622 | 263/18723 | 7.67e-04 | 8.12e-03 | 56 |
GO:00324693 | Colorectum | FAP | endoplasmic reticulum calcium ion homeostasis | 10/2622 | 25/18723 | 1.24e-03 | 1.16e-02 | 10 |
GO:0014829 | Colorectum | FAP | vascular associated smooth muscle contraction | 9/2622 | 26/18723 | 6.73e-03 | 4.14e-02 | 9 |
GO:00515603 | Colorectum | FAP | mitochondrial calcium ion homeostasis | 9/2622 | 26/18723 | 6.73e-03 | 4.14e-02 | 9 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00435473 | Colorectum | CRC | positive regulation of GTPase activity | 49/2078 | 255/18723 | 8.67e-05 | 1.77e-03 | 49 |
GO:00030123 | Colorectum | CRC | muscle system process | 74/2078 | 452/18723 | 3.92e-04 | 5.80e-03 | 74 |
GO:00324694 | Colorectum | CRC | endoplasmic reticulum calcium ion homeostasis | 9/2078 | 25/18723 | 9.76e-04 | 1.17e-02 | 9 |
GO:00515604 | Colorectum | CRC | mitochondrial calcium ion homeostasis | 9/2078 | 26/18723 | 1.35e-03 | 1.49e-02 | 9 |
GO:00030181 | Colorectum | CRC | vascular process in circulatory system | 45/2078 | 263/18723 | 2.10e-03 | 2.08e-02 | 45 |
GO:0032469110 | Esophagus | ESCC | endoplasmic reticulum calcium ion homeostasis | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430875 | Liver | NAFLD | regulation of GTPase activity | 62/1882 | 348/18723 | 5.65e-06 | 2.03e-04 | 62 |
GO:00435474 | Liver | NAFLD | positive regulation of GTPase activity | 45/1882 | 255/18723 | 1.30e-04 | 2.47e-03 | 45 |
GO:00030182 | Liver | NAFLD | vascular process in circulatory system | 46/1882 | 263/18723 | 1.36e-04 | 2.58e-03 | 46 |
GO:00515613 | Liver | NAFLD | positive regulation of mitochondrial calcium ion concentration | 5/1882 | 11/18723 | 2.81e-03 | 2.55e-02 | 5 |
GO:00515605 | Liver | NAFLD | mitochondrial calcium ion homeostasis | 8/1882 | 26/18723 | 3.06e-03 | 2.75e-02 | 8 |
GO:0035296 | Liver | NAFLD | regulation of tube diameter | 24/1882 | 141/18723 | 7.04e-03 | 4.91e-02 | 24 |
GO:0097746 | Liver | NAFLD | blood vessel diameter maintenance | 24/1882 | 141/18723 | 7.04e-03 | 4.91e-02 | 24 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAP1GDS1 | SNV | Missense_Mutation | | c.764A>G | p.Asn255Ser | p.N255S | P52306 | protein_coding | tolerated(0.18) | benign(0.076) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RAP1GDS1 | SNV | Missense_Mutation | | c.1528N>C | p.Glu510Gln | p.E510Q | P52306 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RAP1GDS1 | SNV | Missense_Mutation | | c.1619N>G | p.His540Arg | p.H540R | P52306 | protein_coding | deleterious(0.04) | benign(0.025) | TCGA-D8-A1JD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
RAP1GDS1 | SNV | Missense_Mutation | | c.1518N>G | p.Ile506Met | p.I506M | P52306 | protein_coding | deleterious(0.01) | probably_damaging(0.921) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
RAP1GDS1 | deletion | Frame_Shift_Del | novel | c.893delN | p.Leu299TyrfsTer57 | p.L299Yfs*57 | P52306 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RAP1GDS1 | SNV | Missense_Mutation | rs377518587 | c.149G>A | p.Gly50Glu | p.G50E | P52306 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
RAP1GDS1 | insertion | In_Frame_Ins | novel | c.1287_1288insGAATTCAGTTGT | p.Met429_Leu430insGluPheSerCys | p.M429_L430insEFSC | P52306 | protein_coding | | | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
RAP1GDS1 | SNV | Missense_Mutation | | c.568N>A | p.Leu190Met | p.L190M | P52306 | protein_coding | tolerated(0.19) | probably_damaging(0.998) | TCGA-AA-3655-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RAP1GDS1 | SNV | Missense_Mutation | novel | c.1234N>A | p.Leu412Ile | p.L412I | P52306 | protein_coding | tolerated(0.07) | possibly_damaging(0.756) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RAP1GDS1 | SNV | Missense_Mutation | | c.1598N>T | p.Ala533Val | p.A533V | P52306 | protein_coding | deleterious(0.05) | possibly_damaging(0.786) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |