Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: RALY

Gene summary for RALY

Gene summary.

Gene information	Species	Human
	Gene symbol	RALY
	Gene ID	22913
	Gene name	RALY heterogeneous nuclear ribonucleoprotein
	Gene Alias	HNRPCL2
	Cytomap	20q11.22
	Gene Type	protein-coding
	GO ID	GO:0000375
	UniProtAcc	Q9UKM9

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
22913	RALY	HTA11_2487_2000001011	Human	Colorectum	SER	9.82e-03	4.85e-01	-0.1808
22913	RALY	HTA11_347_2000001011	Human	Colorectum	AD	1.03e-03	4.21e-01	-0.1954
22913	RALY	HTA11_411_2000001011	Human	Colorectum	SER	3.16e-06	8.54e-01	-0.2602
22913	RALY	HTA11_99999965104_69814	Human	Colorectum	MSS	1.12e-05	6.25e-01	0.281
22913	RALY	HTA11_99999971662_82457	Human	Colorectum	MSS	1.88e-10	8.40e-01	0.3859
22913	RALY	HTA11_99999974143_84620	Human	Colorectum	MSS	4.39e-05	5.04e-01	0.3005
22913	RALY	F007	Human	Colorectum	FAP	2.96e-04	-2.22e-01	0.1176
22913	RALY	A002-C-010	Human	Colorectum	FAP	1.05e-06	-1.96e-01	0.242
22913	RALY	A001-C-207	Human	Colorectum	FAP	4.87e-07	-2.95e-01	0.1278
22913	RALY	A015-C-203	Human	Colorectum	FAP	2.96e-29	-3.84e-01	-0.1294
22913	RALY	A015-C-204	Human	Colorectum	FAP	5.61e-09	-3.20e-01	-0.0228
22913	RALY	A014-C-040	Human	Colorectum	FAP	1.43e-05	-4.74e-01	-0.1184
22913	RALY	A002-C-201	Human	Colorectum	FAP	8.05e-17	-4.02e-01	0.0324
22913	RALY	A002-C-203	Human	Colorectum	FAP	5.61e-04	-1.07e-01	0.2786
22913	RALY	A001-C-119	Human	Colorectum	FAP	8.97e-16	-5.93e-01	-0.1557
22913	RALY	A001-C-108	Human	Colorectum	FAP	3.22e-20	-3.96e-01	-0.0272
22913	RALY	A002-C-205	Human	Colorectum	FAP	1.14e-24	-4.47e-01	-0.1236
22913	RALY	A001-C-104	Human	Colorectum	FAP	1.59e-06	-3.11e-01	0.0184
22913	RALY	A015-C-005	Human	Colorectum	FAP	1.26e-09	-3.73e-01	-0.0336
22913	RALY	A015-C-006	Human	Colorectum	FAP	3.73e-21	-5.44e-01	-0.0994

Page: 1 2 3 4 5 6 7 8 9

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:0008380111	Esophagus	ESCC	RNA splicing	336/8552	434/18723	1.74e-42	3.67e-39	336
GO:0000375111	Esophagus	ESCC	RNA splicing, via transesterification reactions	248/8552	324/18723	3.05e-30	1.49e-27	248
GO:0000377111	Esophagus	ESCC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	244/8552	320/18723	2.52e-29	1.07e-26	244
GO:0000398111	Esophagus	ESCC	mRNA splicing, via spliceosome	244/8552	320/18723	2.52e-29	1.07e-26	244
GO:000838012	Liver	Cirrhotic	RNA splicing	229/4634	434/18723	9.13e-37	2.86e-33	229
GO:000037512	Liver	Cirrhotic	RNA splicing, via transesterification reactions	175/4634	324/18723	5.95e-30	7.47e-27	175
GO:000037712	Liver	Cirrhotic	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	172/4634	320/18723	4.02e-29	3.60e-26	172
GO:000039812	Liver	Cirrhotic	mRNA splicing, via spliceosome	172/4634	320/18723	4.02e-29	3.60e-26	172
GO:005508811	Liver	Cirrhotic	lipid homeostasis	74/4634	167/18723	2.46e-08	8.51e-07	74
GO:004263211	Liver	Cirrhotic	cholesterol homeostasis	46/4634	96/18723	7.15e-07	1.52e-05	46
GO:005509211	Liver	Cirrhotic	sterol homeostasis	46/4634	97/18723	1.04e-06	2.13e-05	46
GO:000838022	Liver	HCC	RNA splicing	313/7958	434/18723	1.36e-36	1.73e-33	313
GO:000037522	Liver	HCC	RNA splicing, via transesterification reactions	228/7958	324/18723	1.47e-24	4.06e-22	228
GO:000037722	Liver	HCC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	224/7958	320/18723	1.16e-23	2.62e-21	224
GO:000039822	Liver	HCC	mRNA splicing, via spliceosome	224/7958	320/18723	1.16e-23	2.62e-21	224
GO:00550882	Liver	HCC	lipid homeostasis	103/7958	167/18723	4.27e-07	7.18e-06	103
GO:005509221	Liver	HCC	sterol homeostasis	59/7958	97/18723	2.06e-04	1.58e-03	59
GO:004263221	Liver	HCC	cholesterol homeostasis	58/7958	96/18723	2.99e-04	2.13e-03	58
GO:00083808	Lung	IAC	RNA splicing	75/2061	434/18723	4.89e-05	1.12e-03	75
GO:00003778	Lung	IAC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	52/2061	320/18723	2.64e-03	2.44e-02	52

Page: 1 2 3 4

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

RALY

SNV

Missense_Mutation

novel

c.898N>T

p.Ala300Ser

p.A300S

Q9UKM9

protein_coding

deleterious_low_confidence(0.03)

benign(0.285)

TCGA-A2-A25A-01

Breast

breast invasive carcinoma

Female

<65

I/II

Unspecific

Cytoxan

RALY

SNV

Missense_Mutation

rs768865097

c.364N>A

p.Asp122Asn

p.D122N

Q9UKM9

protein_coding

tolerated(0.08)

possibly_damaging(0.494)

TCGA-AQ-A0Y5-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

cytoxan

RALY

SNV

Missense_Mutation

c.406N>A

p.Pro136Thr

p.P136T

Q9UKM9

protein_coding

deleterious(0)

possibly_damaging(0.714)

TCGA-BH-A0BZ-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

doxorubicin

RALY

SNV

Missense_Mutation

c.169T>C

p.Tyr57His

p.Y57H

Q9UKM9

protein_coding

deleterious(0.02)

possibly_damaging(0.739)

TCGA-D8-A1XQ-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

RALY

SNV

Missense_Mutation

novel

c.205N>T

p.Arg69Trp

p.R69W

Q9UKM9

protein_coding

deleterious(0.05)

benign(0.362)

TCGA-LL-A73Y-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

taxotere

RALY

SNV

Missense_Mutation

novel

c.185A>G

p.Tyr62Cys

p.Y62C

Q9UKM9

protein_coding

deleterious(0.04)

benign(0.434)

TCGA-LL-A740-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

adriamycin

RALY

SNV

Missense_Mutation

c.271N>A

p.Gly91Arg

p.G91R

Q9UKM9

protein_coding

deleterious(0)

probably_damaging(0.995)

TCGA-EK-A2PG-01

Cervix

cervical & endocervical cancer

Female

>=65

I/II

Unknown

RALY

SNV

Missense_Mutation

c.67G>C

p.Val23Leu

p.V23L

Q9UKM9

protein_coding

deleterious(0.01)

probably_damaging(0.997)

TCGA-LP-A4AW-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

RALY

SNV

Missense_Mutation

novel

c.233N>A

p.Arg78Gln

p.R78Q

Q9UKM9

protein_coding

deleterious(0.03)

benign(0.074)

TCGA-AA-3864-01

Colorectum

colon adenocarcinoma

Male

>=65

I/II

Unknown

RALY

SNV

Missense_Mutation

c.104N>C

p.Lys35Thr

p.K35T

Q9UKM9

protein_coding

deleterious(0.01)

probably_damaging(0.999)

TCGA-AA-3977-01

Colorectum

colon adenocarcinoma

Male

>=65

I/II

Unknown

Page: 1 2 3 4

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1