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Gene: PSMD7 |
Gene summary for PSMD7 |
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Gene information | Species | Human | Gene symbol | PSMD7 | Gene ID | 5713 |
Gene name | proteasome 26S subunit, non-ATPase 7 | |
Gene Alias | MOV34 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P51665 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5713 | PSMD7 | GSM4909281 | Human | Breast | IDC | 1.02e-04 | 3.04e-01 | 0.21 |
5713 | PSMD7 | GSM4909282 | Human | Breast | IDC | 2.41e-13 | 3.51e-01 | -0.0288 |
5713 | PSMD7 | GSM4909296 | Human | Breast | IDC | 5.07e-05 | 2.44e-02 | 0.1524 |
5713 | PSMD7 | GSM4909297 | Human | Breast | IDC | 1.03e-09 | -2.46e-01 | 0.1517 |
5713 | PSMD7 | GSM4909311 | Human | Breast | IDC | 7.63e-25 | -2.39e-01 | 0.1534 |
5713 | PSMD7 | GSM4909312 | Human | Breast | IDC | 4.52e-07 | -1.37e-01 | 0.1552 |
5713 | PSMD7 | GSM4909317 | Human | Breast | IDC | 4.43e-02 | 2.16e-01 | 0.1355 |
5713 | PSMD7 | GSM4909319 | Human | Breast | IDC | 1.66e-24 | -2.80e-01 | 0.1563 |
5713 | PSMD7 | GSM4909320 | Human | Breast | IDC | 2.63e-05 | -3.19e-01 | 0.1575 |
5713 | PSMD7 | GSM4909321 | Human | Breast | IDC | 1.25e-10 | -6.26e-02 | 0.1559 |
5713 | PSMD7 | brca1 | Human | Breast | Precancer | 1.22e-35 | 7.24e-01 | -0.0338 |
5713 | PSMD7 | brca2 | Human | Breast | Precancer | 3.63e-11 | 4.02e-01 | -0.024 |
5713 | PSMD7 | brca3 | Human | Breast | Precancer | 1.70e-10 | 3.70e-01 | -0.0263 |
5713 | PSMD7 | NCCBC14 | Human | Breast | DCIS | 2.51e-02 | 5.19e-02 | 0.2021 |
5713 | PSMD7 | NCCBC2 | Human | Breast | DCIS | 1.90e-02 | 2.09e-03 | 0.1554 |
5713 | PSMD7 | NCCBC5 | Human | Breast | DCIS | 3.70e-05 | -1.25e-01 | 0.2046 |
5713 | PSMD7 | P1 | Human | Breast | IDC | 2.42e-15 | -9.09e-02 | 0.1527 |
5713 | PSMD7 | P2 | Human | Breast | IDC | 4.50e-16 | 6.40e-01 | 0.21 |
5713 | PSMD7 | DCIS2 | Human | Breast | DCIS | 1.63e-58 | 1.99e-01 | 0.0085 |
5713 | PSMD7 | AEH-subject1 | Human | Endometrium | AEH | 3.31e-03 | -2.05e-01 | -0.3059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498110 | Oral cavity | LP | proteasomal protein catabolic process | 224/4623 | 490/18723 | 9.57e-25 | 4.00e-22 | 224 |
GO:0043161110 | Oral cavity | LP | proteasome-mediated ubiquitin-dependent protein catabolic process | 190/4623 | 412/18723 | 1.08e-21 | 2.93e-19 | 190 |
GO:001049831 | Oral cavity | NEOLP | proteasomal protein catabolic process | 103/2005 | 490/18723 | 1.08e-11 | 1.65e-09 | 103 |
GO:004316131 | Oral cavity | NEOLP | proteasome-mediated ubiquitin-dependent protein catabolic process | 89/2005 | 412/18723 | 6.27e-11 | 7.44e-09 | 89 |
GO:001049818 | Prostate | BPH | proteasomal protein catabolic process | 153/3107 | 490/18723 | 4.13e-16 | 7.51e-14 | 153 |
GO:004316118 | Prostate | BPH | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3107 | 412/18723 | 3.84e-13 | 3.60e-11 | 127 |
GO:001049819 | Prostate | Tumor | proteasomal protein catabolic process | 158/3246 | 490/18723 | 3.05e-16 | 6.76e-14 | 158 |
GO:004316119 | Prostate | Tumor | proteasome-mediated ubiquitin-dependent protein catabolic process | 130/3246 | 412/18723 | 7.97e-13 | 8.00e-11 | 130 |
GO:001049827 | Skin | AK | proteasomal protein catabolic process | 97/1910 | 490/18723 | 9.65e-11 | 1.54e-08 | 97 |
GO:004316127 | Skin | AK | proteasome-mediated ubiquitin-dependent protein catabolic process | 84/1910 | 412/18723 | 3.96e-10 | 4.88e-08 | 84 |
GO:001049828 | Skin | cSCC | proteasomal protein catabolic process | 243/4864 | 490/18723 | 7.85e-30 | 4.10e-27 | 243 |
GO:004316128 | Skin | cSCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 205/4864 | 412/18723 | 1.46e-25 | 4.16e-23 | 205 |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305010 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516918 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0305013 | Breast | Precancer | Proteasome | 25/684 | 46/8465 | 4.35e-16 | 9.81e-15 | 7.52e-15 | 25 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0516919 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSMD7 | SNV | Missense_Mutation | c.148G>A | p.Val50Ile | p.V50I | P51665 | protein_coding | tolerated(0.17) | benign(0.085) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | |
PSMD7 | SNV | Missense_Mutation | novel | c.502N>A | p.Glu168Lys | p.E168K | P51665 | protein_coding | deleterious(0.04) | probably_damaging(0.929) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PSMD7 | SNV | Missense_Mutation | novel | c.376N>A | p.Val126Met | p.V126M | P51665 | protein_coding | deleterious(0.05) | possibly_damaging(0.594) | TCGA-ZJ-AAXD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PSMD7 | SNV | Missense_Mutation | c.328N>A | p.Glu110Lys | p.E110K | P51665 | protein_coding | deleterious(0) | benign(0.406) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PSMD7 | SNV | Missense_Mutation | novel | c.894N>T | p.Lys298Asn | p.K298N | P51665 | protein_coding | tolerated(0.2) | probably_damaging(0.95) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PSMD7 | SNV | Missense_Mutation | novel | c.383N>T | p.Pro128Leu | p.P128L | P51665 | protein_coding | deleterious(0.02) | benign(0.014) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PSMD7 | SNV | Missense_Mutation | rs575506029 | c.569N>A | p.Arg190Gln | p.R190Q | P51665 | protein_coding | tolerated(0.16) | benign(0.036) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PSMD7 | SNV | Missense_Mutation | novel | c.504N>T | p.Glu168Asp | p.E168D | P51665 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMD7 | SNV | Missense_Mutation | c.661N>T | p.Pro221Ser | p.P221S | P51665 | protein_coding | deleterious(0.05) | possibly_damaging(0.808) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
PSMD7 | SNV | Missense_Mutation | c.79N>A | p.Gly27Ser | p.G27S | P51665 | protein_coding | tolerated(0.31) | benign(0.006) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5713 | PSMD7 | PROTEASE | PROTEASOME INHIBITOR | 15221960 | ||
5713 | PSMD7 | PROTEASE | BORTEZOMIB | BORTEZOMIB | 24524217 | |
5713 | PSMD7 | PROTEASE | inhibitor | CARFILZOMIB | CARFILZOMIB | |
5713 | PSMD7 | PROTEASE | CARFILZOMIB | CARFILZOMIB | 24524217 | |
5713 | PSMD7 | PROTEASE | inhibitor | CHEMBL451887 | CARFILZOMIB | |
5713 | PSMD7 | PROTEASE | inhibitor | BORTEZOMIB | BORTEZOMIB | |
5713 | PSMD7 | PROTEASE | inhibitor | CHEMBL325041 | BORTEZOMIB | |
5713 | PSMD7 | PROTEASE | inhibitor | CHEMBL2103884 | OPROZOMIB | |
5713 | PSMD7 | PROTEASE | inhibitor | CHEMBL3545432 | IXAZOMIB CITRATE |
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