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Gene: PPA2 |
Gene summary for PPA2 |
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Gene information | Species | Human | Gene symbol | PPA2 | Gene ID | 27068 |
Gene name | inorganic pyrophosphatase 2 | |
Gene Alias | HSPC124 | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9H2U2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27068 | PPA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.33e-13 | -4.81e-01 | 0.0155 |
27068 | PPA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.59e-02 | 3.50e-01 | -0.1954 |
27068 | PPA2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.04e-07 | -3.55e-01 | -0.1001 |
27068 | PPA2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.33e-04 | -2.56e-01 | 0.0674 |
27068 | PPA2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.39e-05 | -5.32e-01 | 0.2585 |
27068 | PPA2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.33e-15 | -4.98e-01 | 0.3005 |
27068 | PPA2 | F007 | Human | Colorectum | FAP | 5.15e-03 | -2.84e-01 | 0.1176 |
27068 | PPA2 | A001-C-207 | Human | Colorectum | FAP | 3.02e-06 | -3.94e-01 | 0.1278 |
27068 | PPA2 | A015-C-203 | Human | Colorectum | FAP | 2.34e-39 | -6.48e-01 | -0.1294 |
27068 | PPA2 | A015-C-204 | Human | Colorectum | FAP | 7.29e-10 | -3.97e-01 | -0.0228 |
27068 | PPA2 | A014-C-040 | Human | Colorectum | FAP | 3.98e-05 | -4.24e-01 | -0.1184 |
27068 | PPA2 | A002-C-201 | Human | Colorectum | FAP | 5.51e-19 | -4.75e-01 | 0.0324 |
27068 | PPA2 | A002-C-203 | Human | Colorectum | FAP | 2.05e-05 | -1.25e-01 | 0.2786 |
27068 | PPA2 | A001-C-119 | Human | Colorectum | FAP | 8.21e-23 | -7.87e-01 | -0.1557 |
27068 | PPA2 | A001-C-108 | Human | Colorectum | FAP | 2.08e-29 | -5.54e-01 | -0.0272 |
27068 | PPA2 | A002-C-205 | Human | Colorectum | FAP | 4.57e-29 | -6.04e-01 | -0.1236 |
27068 | PPA2 | A001-C-104 | Human | Colorectum | FAP | 2.17e-10 | -4.14e-01 | 0.0184 |
27068 | PPA2 | A015-C-005 | Human | Colorectum | FAP | 1.34e-07 | -4.10e-01 | -0.0336 |
27068 | PPA2 | A015-C-006 | Human | Colorectum | FAP | 1.19e-23 | -6.94e-01 | -0.0994 |
27068 | PPA2 | A015-C-106 | Human | Colorectum | FAP | 7.54e-24 | -4.65e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:005188112 | Liver | HCC | regulation of mitochondrial membrane potential | 45/7958 | 74/18723 | 1.13e-03 | 6.43e-03 | 45 |
GO:00064707 | Lung | IAC | protein dephosphorylation | 60/2061 | 281/18723 | 3.24e-07 | 2.48e-05 | 60 |
GO:00163116 | Lung | IAC | dephosphorylation | 75/2061 | 417/18723 | 1.21e-05 | 3.64e-04 | 75 |
GO:000647012 | Lung | AIS | protein dephosphorylation | 56/1849 | 281/18723 | 2.47e-07 | 2.24e-05 | 56 |
GO:001631112 | Lung | AIS | dephosphorylation | 69/1849 | 417/18723 | 1.27e-05 | 4.78e-04 | 69 |
GO:000647015 | Oral cavity | OSCC | protein dephosphorylation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:00518819 | Oral cavity | OSCC | regulation of mitochondrial membrane potential | 46/7305 | 74/18723 | 4.61e-05 | 3.90e-04 | 46 |
GO:005188116 | Oral cavity | LP | regulation of mitochondrial membrane potential | 36/4623 | 74/18723 | 6.85e-06 | 1.34e-04 | 36 |
GO:000647016 | Oral cavity | LP | protein dephosphorylation | 89/4623 | 281/18723 | 4.60e-03 | 2.93e-02 | 89 |
GO:000647023 | Oral cavity | EOLP | protein dephosphorylation | 72/2218 | 281/18723 | 1.19e-10 | 1.35e-08 | 72 |
GO:001631114 | Oral cavity | EOLP | dephosphorylation | 85/2218 | 417/18723 | 3.19e-07 | 9.47e-06 | 85 |
GO:005188123 | Oral cavity | EOLP | regulation of mitochondrial membrane potential | 18/2218 | 74/18723 | 2.08e-03 | 1.32e-02 | 18 |
GO:000647024 | Skin | cSCC | protein dephosphorylation | 111/4864 | 281/18723 | 4.10e-07 | 7.96e-06 | 111 |
GO:005188118 | Skin | cSCC | regulation of mitochondrial membrane potential | 38/4864 | 74/18723 | 2.67e-06 | 4.28e-05 | 38 |
GO:001631115 | Skin | cSCC | dephosphorylation | 134/4864 | 417/18723 | 2.65e-03 | 1.50e-02 | 134 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00190 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa001901 | Colorectum | AD | Oxidative phosphorylation | 86/2092 | 134/8465 | 2.47e-22 | 2.76e-20 | 1.76e-20 | 86 |
hsa001904 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa001905 | Colorectum | MSS | Oxidative phosphorylation | 79/1875 | 134/8465 | 1.89e-20 | 7.90e-19 | 4.84e-19 | 79 |
hsa001908 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
hsa001909 | Colorectum | FAP | Oxidative phosphorylation | 44/1404 | 134/8465 | 2.56e-06 | 4.28e-05 | 2.60e-05 | 44 |
hsa00190210 | Esophagus | ESCC | Oxidative phosphorylation | 104/4205 | 134/8465 | 2.04e-11 | 2.98e-10 | 1.53e-10 | 104 |
hsa0019038 | Esophagus | ESCC | Oxidative phosphorylation | 104/4205 | 134/8465 | 2.04e-11 | 2.98e-10 | 1.53e-10 | 104 |
hsa0019014 | Liver | Cirrhotic | Oxidative phosphorylation | 83/2530 | 134/8465 | 1.03e-14 | 3.44e-13 | 2.12e-13 | 83 |
hsa0019015 | Liver | Cirrhotic | Oxidative phosphorylation | 83/2530 | 134/8465 | 1.03e-14 | 3.44e-13 | 2.12e-13 | 83 |
hsa0019022 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa0019032 | Liver | HCC | Oxidative phosphorylation | 103/4020 | 134/8465 | 2.39e-12 | 5.01e-11 | 2.79e-11 | 103 |
hsa0019028 | Oral cavity | OSCC | Oxidative phosphorylation | 88/3704 | 134/8465 | 2.15e-07 | 1.44e-06 | 7.32e-07 | 88 |
hsa00190112 | Oral cavity | OSCC | Oxidative phosphorylation | 88/3704 | 134/8465 | 2.15e-07 | 1.44e-06 | 7.32e-07 | 88 |
hsa0019029 | Oral cavity | LP | Oxidative phosphorylation | 81/2418 | 134/8465 | 9.58e-15 | 2.45e-13 | 1.58e-13 | 81 |
hsa0019037 | Oral cavity | LP | Oxidative phosphorylation | 81/2418 | 134/8465 | 9.58e-15 | 2.45e-13 | 1.58e-13 | 81 |
hsa0019045 | Oral cavity | EOLP | Oxidative phosphorylation | 36/1218 | 134/8465 | 1.05e-04 | 4.57e-04 | 2.69e-04 | 36 |
hsa0019055 | Oral cavity | EOLP | Oxidative phosphorylation | 36/1218 | 134/8465 | 1.05e-04 | 4.57e-04 | 2.69e-04 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPA2 | SNV | Missense_Mutation | rs772083375 | c.182N>T | p.Ser61Phe | p.S61F | Q9H2U2 | protein_coding | deleterious(0) | possibly_damaging(0.832) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPA2 | SNV | Missense_Mutation | novel | c.817C>G | p.Gln273Glu | p.Q273E | Q9H2U2 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
PPA2 | insertion | Frame_Shift_Ins | novel | c.779dupA | p.Asn260LysfsTer7 | p.N260Kfs*7 | Q9H2U2 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PPA2 | SNV | Missense_Mutation | rs765643758 | c.482G>A | p.Cys161Tyr | p.C161Y | Q9H2U2 | protein_coding | deleterious(0.02) | benign(0.335) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPA2 | SNV | Missense_Mutation | c.315A>C | p.Lys105Asn | p.K105N | Q9H2U2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PPA2 | SNV | Missense_Mutation | c.92C>T | p.Ala31Val | p.A31V | Q9H2U2 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPA2 | SNV | Missense_Mutation | rs146599366 | c.902G>A | p.Arg301His | p.R301H | Q9H2U2 | protein_coding | tolerated(0.58) | benign(0) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PPA2 | SNV | Missense_Mutation | c.532C>A | p.Leu178Ile | p.L178I | Q9H2U2 | protein_coding | tolerated(0.36) | benign(0.062) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPA2 | SNV | Missense_Mutation | novel | c.415A>C | p.Ile139Leu | p.I139L | Q9H2U2 | protein_coding | tolerated(0.08) | probably_damaging(0.987) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPA2 | SNV | Missense_Mutation | novel | c.389N>T | p.Ala130Val | p.A130V | Q9H2U2 | protein_coding | tolerated(0.06) | possibly_damaging(0.473) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27068 | PPA2 | ENZYME | risperidone | RISPERIDONE |
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