GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:000640118 | Oral cavity | OSCC | RNA catabolic process | 184/7305 | 278/18723 | 2.71e-20 | 4.19e-18 | 184 |
GO:003465517 | Oral cavity | OSCC | nucleobase-containing compound catabolic process | 244/7305 | 407/18723 | 5.38e-18 | 5.49e-16 | 244 |
GO:004670015 | Oral cavity | OSCC | heterocycle catabolic process | 254/7305 | 445/18723 | 5.07e-15 | 3.31e-13 | 254 |
GO:004427016 | Oral cavity | OSCC | cellular nitrogen compound catabolic process | 256/7305 | 451/18723 | 9.67e-15 | 5.88e-13 | 256 |
GO:001943915 | Oral cavity | OSCC | aromatic compound catabolic process | 263/7305 | 467/18723 | 1.49e-14 | 8.84e-13 | 263 |
GO:190136115 | Oral cavity | OSCC | organic cyclic compound catabolic process | 272/7305 | 495/18723 | 2.73e-13 | 1.36e-11 | 272 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00080332 | Oral cavity | OSCC | tRNA processing | 78/7305 | 127/18723 | 2.56e-07 | 4.00e-06 | 78 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00063991 | Oral cavity | OSCC | tRNA metabolic process | 101/7305 | 179/18723 | 1.65e-06 | 2.15e-05 | 101 |
GO:00991162 | Oral cavity | OSCC | tRNA 5'-end processing | 14/7305 | 16/18723 | 9.15e-05 | 6.93e-04 | 14 |
GO:00344712 | Oral cavity | OSCC | ncRNA 5'-end processing | 17/7305 | 21/18723 | 1.07e-04 | 7.89e-04 | 17 |
GO:00009662 | Oral cavity | OSCC | RNA 5'-end processing | 18/7305 | 23/18723 | 1.47e-04 | 1.04e-03 | 18 |
GO:00346612 | Oral cavity | OSCC | ncRNA catabolic process | 28/7305 | 43/18723 | 4.71e-04 | 2.79e-03 | 28 |
GO:00016822 | Oral cavity | OSCC | tRNA 5'-leader removal | 11/7305 | 13/18723 | 1.02e-03 | 5.29e-03 | 11 |
GO:00905022 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 44/7305 | 82/18723 | 4.95e-03 | 1.94e-02 | 44 |
GO:00160781 | Oral cavity | OSCC | tRNA catabolic process | 10/7305 | 13/18723 | 6.32e-03 | 2.35e-02 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POP1 | SNV | Missense_Mutation | | c.3051N>G | p.Phe1017Leu | p.F1017L | Q99575 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
POP1 | SNV | Missense_Mutation | novel | c.2557N>A | p.Pro853Thr | p.P853T | Q99575 | protein_coding | deleterious(0.01) | possibly_damaging(0.811) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
POP1 | SNV | Missense_Mutation | | c.2461N>T | p.Pro821Ser | p.P821S | Q99575 | protein_coding | tolerated(0.09) | probably_damaging(0.987) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POP1 | SNV | Missense_Mutation | novel | c.91G>A | p.Gly31Ser | p.G31S | Q99575 | protein_coding | tolerated(0.24) | benign(0.033) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
POP1 | SNV | Missense_Mutation | | c.2071N>G | p.Lys691Glu | p.K691E | Q99575 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
POP1 | SNV | Missense_Mutation | | c.667G>C | p.Gly223Arg | p.G223R | Q99575 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
POP1 | SNV | Missense_Mutation | | c.1745N>T | p.Pro582Leu | p.P582L | Q99575 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
POP1 | SNV | Missense_Mutation | | c.107N>C | p.Ser36Thr | p.S36T | Q99575 | protein_coding | tolerated(0.2) | benign(0.01) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
POP1 | insertion | Frame_Shift_Ins | novel | c.981_982insAGAAAGAAACT | p.Trp328ArgfsTer17 | p.W328Rfs*17 | Q99575 | protein_coding | | | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
POP1 | insertion | Nonsense_Mutation | novel | c.983_984insAAGCTCTCATTACTCATTTAACACATATTTGTTGA | p.Trp328Ter | p.W328* | Q99575 | protein_coding | | | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |