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Gene: POM121 |
Gene summary for POM121 |
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Gene information | Species | Human | Gene symbol | POM121 | Gene ID | 9883 |
Gene name | POM121 transmembrane nucleoporin | |
Gene Alias | P145 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | Q96HA1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9883 | POM121 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.36e-04 | 2.62e-01 | -0.1954 |
9883 | POM121 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.52e-02 | 3.61e-01 | -0.059 |
9883 | POM121 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.67e-09 | 6.90e-01 | 0.3859 |
9883 | POM121 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.26e-10 | 6.36e-01 | 0.3005 |
9883 | POM121 | F007 | Human | Colorectum | FAP | 3.51e-02 | -3.59e-01 | 0.1176 |
9883 | POM121 | A002-C-010 | Human | Colorectum | FAP | 2.39e-03 | -2.23e-01 | 0.242 |
9883 | POM121 | A015-C-203 | Human | Colorectum | FAP | 1.52e-17 | -3.43e-01 | -0.1294 |
9883 | POM121 | A015-C-204 | Human | Colorectum | FAP | 7.00e-04 | -3.19e-01 | -0.0228 |
9883 | POM121 | A014-C-040 | Human | Colorectum | FAP | 6.53e-03 | -4.07e-01 | -0.1184 |
9883 | POM121 | A002-C-201 | Human | Colorectum | FAP | 9.61e-11 | -3.55e-01 | 0.0324 |
9883 | POM121 | A001-C-119 | Human | Colorectum | FAP | 1.87e-03 | -2.35e-01 | -0.1557 |
9883 | POM121 | A001-C-108 | Human | Colorectum | FAP | 3.90e-11 | -2.61e-01 | -0.0272 |
9883 | POM121 | A002-C-205 | Human | Colorectum | FAP | 5.15e-15 | -2.72e-01 | -0.1236 |
9883 | POM121 | A015-C-006 | Human | Colorectum | FAP | 4.08e-10 | -1.96e-01 | -0.0994 |
9883 | POM121 | A015-C-106 | Human | Colorectum | FAP | 5.72e-09 | -1.89e-01 | -0.0511 |
9883 | POM121 | A002-C-114 | Human | Colorectum | FAP | 2.79e-14 | -4.04e-01 | -0.1561 |
9883 | POM121 | A015-C-104 | Human | Colorectum | FAP | 2.49e-18 | -3.28e-01 | -0.1899 |
9883 | POM121 | A001-C-014 | Human | Colorectum | FAP | 3.39e-11 | -3.59e-01 | 0.0135 |
9883 | POM121 | A002-C-016 | Human | Colorectum | FAP | 2.59e-14 | -3.33e-01 | 0.0521 |
9883 | POM121 | A015-C-002 | Human | Colorectum | FAP | 1.87e-07 | -3.47e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00170382 | Colorectum | MSS | protein import | 65/3467 | 206/18723 | 4.28e-06 | 1.22e-04 | 65 |
GO:00512362 | Colorectum | MSS | establishment of RNA localization | 55/3467 | 166/18723 | 4.54e-06 | 1.27e-04 | 55 |
GO:00506572 | Colorectum | MSS | nucleic acid transport | 54/3467 | 163/18723 | 5.54e-06 | 1.49e-04 | 54 |
GO:00506582 | Colorectum | MSS | RNA transport | 54/3467 | 163/18723 | 5.54e-06 | 1.49e-04 | 54 |
GO:00511682 | Colorectum | MSS | nuclear export | 51/3467 | 154/18723 | 1.01e-05 | 2.43e-04 | 51 |
GO:00511702 | Colorectum | MSS | import into nucleus | 52/3467 | 159/18723 | 1.23e-05 | 2.87e-04 | 52 |
GO:00066062 | Colorectum | MSS | protein import into nucleus | 50/3467 | 155/18723 | 2.72e-05 | 5.58e-04 | 50 |
GO:00510281 | Colorectum | MSS | mRNA transport | 40/3467 | 130/18723 | 4.94e-04 | 5.75e-03 | 40 |
GO:0006405 | Colorectum | MSS | RNA export from nucleus | 27/3467 | 84/18723 | 1.89e-03 | 1.66e-02 | 27 |
GO:00069134 | Colorectum | FAP | nucleocytoplasmic transport | 77/2622 | 301/18723 | 6.15e-08 | 4.54e-06 | 77 |
GO:00511694 | Colorectum | FAP | nuclear transport | 77/2622 | 301/18723 | 6.15e-08 | 4.54e-06 | 77 |
GO:00725944 | Colorectum | FAP | establishment of protein localization to organelle | 96/2622 | 422/18723 | 6.63e-07 | 3.20e-05 | 96 |
GO:00345044 | Colorectum | FAP | protein localization to nucleus | 66/2622 | 290/18723 | 3.47e-05 | 7.64e-04 | 66 |
GO:00064034 | Colorectum | FAP | RNA localization | 47/2622 | 201/18723 | 2.27e-04 | 3.22e-03 | 47 |
GO:00511704 | Colorectum | FAP | import into nucleus | 39/2622 | 159/18723 | 2.68e-04 | 3.64e-03 | 39 |
GO:00066064 | Colorectum | FAP | protein import into nucleus | 38/2622 | 155/18723 | 3.23e-04 | 4.15e-03 | 38 |
GO:00170384 | Colorectum | FAP | protein import | 47/2622 | 206/18723 | 4.10e-04 | 4.94e-03 | 47 |
GO:00511684 | Colorectum | FAP | nuclear export | 37/2622 | 154/18723 | 5.81e-04 | 6.46e-03 | 37 |
GO:00512364 | Colorectum | FAP | establishment of RNA localization | 39/2622 | 166/18723 | 6.71e-04 | 7.28e-03 | 39 |
GO:00506574 | Colorectum | FAP | nucleic acid transport | 38/2622 | 163/18723 | 9.12e-04 | 9.19e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POM121 | SNV | Missense_Mutation | c.409N>A | p.Ala137Thr | p.A137T | Q96HA1 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POM121 | SNV | Missense_Mutation | c.159G>C | p.Glu53Asp | p.E53D | Q96HA1 | protein_coding | tolerated(0.08) | possibly_damaging(0.795) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
POM121 | SNV | Missense_Mutation | c.2713N>A | p.Glu905Lys | p.E905K | Q96HA1 | protein_coding | tolerated(0.05) | benign(0.219) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
POM121 | SNV | Missense_Mutation | c.2977N>A | p.Ser993Thr | p.S993T | Q96HA1 | protein_coding | tolerated_low_confidence(0.67) | benign(0.034) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
POM121 | SNV | Missense_Mutation | novel | c.349G>A | p.Asp117Asn | p.D117N | Q96HA1 | protein_coding | deleterious(0.01) | possibly_damaging(0.691) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
POM121 | SNV | Missense_Mutation | novel | c.2656N>T | p.Ala886Ser | p.A886S | Q96HA1 | protein_coding | tolerated(0.48) | benign(0.009) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
POM121 | insertion | Nonsense_Mutation | novel | c.151_152insACTACCAGACTTTTTAAACAGCTTTATTAAGATATAAT | p.Leu51HisfsTer6 | p.L51Hfs*6 | Q96HA1 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
POM121 | SNV | Missense_Mutation | c.2836T>G | p.Phe946Val | p.F946V | Q96HA1 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
POM121 | SNV | Missense_Mutation | novel | c.351N>G | p.Asp117Glu | p.D117E | Q96HA1 | protein_coding | tolerated(0.19) | benign(0.039) | TCGA-AA-3818-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
POM121 | SNV | Missense_Mutation | novel | c.1700N>T | p.Ser567Leu | p.S567L | Q96HA1 | protein_coding | tolerated(0.71) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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