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Gene: PLS3 |
Gene summary for PLS3 |
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Gene information | Species | Human | Gene symbol | PLS3 | Gene ID | 5358 |
Gene name | plastin 3 | |
Gene Alias | BMND18 | |
Cytomap | Xq23 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P13797 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5358 | PLS3 | CA_HPV_1 | Human | Cervix | CC | 2.96e-02 | -1.08e-01 | 0.0264 |
5358 | PLS3 | CA_HPV_2 | Human | Cervix | CC | 1.02e-02 | 2.00e-01 | 0.0391 |
5358 | PLS3 | CA_HPV_3 | Human | Cervix | CC | 1.73e-03 | 1.60e-01 | 0.0414 |
5358 | PLS3 | CCI_1 | Human | Cervix | CC | 7.59e-04 | 9.93e-01 | 0.528 |
5358 | PLS3 | Tumor | Human | Cervix | CC | 7.78e-30 | 6.24e-01 | 0.1241 |
5358 | PLS3 | sample3 | Human | Cervix | CC | 4.68e-46 | 7.80e-01 | 0.1387 |
5358 | PLS3 | T3 | Human | Cervix | CC | 1.12e-46 | 7.49e-01 | 0.1389 |
5358 | PLS3 | LZE4T | Human | Esophagus | ESCC | 1.92e-29 | 1.13e+00 | 0.0811 |
5358 | PLS3 | LZE7T | Human | Esophagus | ESCC | 6.53e-15 | 1.03e+00 | 0.0667 |
5358 | PLS3 | LZE8T | Human | Esophagus | ESCC | 2.88e-03 | 2.24e-01 | 0.067 |
5358 | PLS3 | LZE20T | Human | Esophagus | ESCC | 5.42e-13 | 7.07e-01 | 0.0662 |
5358 | PLS3 | LZE22D1 | Human | Esophagus | HGIN | 8.76e-05 | 1.84e-01 | 0.0595 |
5358 | PLS3 | LZE22T | Human | Esophagus | ESCC | 5.13e-10 | 1.58e+00 | 0.068 |
5358 | PLS3 | LZE24T | Human | Esophagus | ESCC | 8.05e-25 | 9.65e-01 | 0.0596 |
5358 | PLS3 | LZE6T | Human | Esophagus | ESCC | 5.81e-03 | 4.41e-01 | 0.0845 |
5358 | PLS3 | P1T-E | Human | Esophagus | ESCC | 9.86e-06 | 6.29e-01 | 0.0875 |
5358 | PLS3 | P2T-E | Human | Esophagus | ESCC | 9.17e-39 | 7.54e-01 | 0.1177 |
5358 | PLS3 | P4T-E | Human | Esophagus | ESCC | 1.74e-30 | 7.09e-01 | 0.1323 |
5358 | PLS3 | P5T-E | Human | Esophagus | ESCC | 3.93e-50 | 1.19e+00 | 0.1327 |
5358 | PLS3 | P8T-E | Human | Esophagus | ESCC | 7.09e-51 | 1.15e+00 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005101733 | Oral cavity | NEOLP | actin filament bundle assembly | 36/2005 | 157/18723 | 7.50e-06 | 1.48e-04 | 36 |
GO:006157226 | Oral cavity | NEOLP | actin filament bundle organization | 36/2005 | 161/18723 | 1.36e-05 | 2.41e-04 | 36 |
GO:006034821 | Oral cavity | NEOLP | bone development | 38/2005 | 205/18723 | 5.28e-04 | 4.64e-03 | 38 |
GO:000701518 | Prostate | BPH | actin filament organization | 147/3107 | 442/18723 | 3.36e-18 | 1.15e-15 | 147 |
GO:005101718 | Prostate | BPH | actin filament bundle assembly | 65/3107 | 157/18723 | 1.31e-13 | 1.38e-11 | 65 |
GO:006157218 | Prostate | BPH | actin filament bundle organization | 65/3107 | 161/18723 | 5.29e-13 | 4.75e-11 | 65 |
GO:00603483 | Prostate | BPH | bone development | 50/3107 | 205/18723 | 2.60e-03 | 1.39e-02 | 50 |
GO:0051639 | Prostate | BPH | actin filament network formation | 6/3107 | 12/18723 | 7.73e-03 | 3.39e-02 | 6 |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:005101719 | Prostate | Tumor | actin filament bundle assembly | 63/3246 | 157/18723 | 1.18e-11 | 9.07e-10 | 63 |
GO:006157219 | Prostate | Tumor | actin filament bundle organization | 63/3246 | 161/18723 | 4.23e-11 | 2.82e-09 | 63 |
GO:006034811 | Prostate | Tumor | bone development | 50/3246 | 205/18723 | 6.30e-03 | 2.89e-02 | 50 |
GO:000701529 | Skin | cSCC | actin filament organization | 156/4864 | 442/18723 | 7.37e-06 | 1.02e-04 | 156 |
GO:005101729 | Skin | cSCC | actin filament bundle assembly | 60/4864 | 157/18723 | 4.86e-04 | 3.66e-03 | 60 |
GO:006157229 | Skin | cSCC | actin filament bundle organization | 60/4864 | 161/18723 | 1.02e-03 | 6.86e-03 | 60 |
GO:000701530 | Thyroid | HT | actin filament organization | 50/1272 | 442/18723 | 2.71e-04 | 3.73e-03 | 50 |
GO:005101730 | Thyroid | HT | actin filament bundle assembly | 23/1272 | 157/18723 | 3.91e-04 | 4.90e-03 | 23 |
GO:006157230 | Thyroid | HT | actin filament bundle organization | 23/1272 | 161/18723 | 5.63e-04 | 6.62e-03 | 23 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0051017112 | Thyroid | PTC | actin filament bundle assembly | 83/5968 | 157/18723 | 3.73e-08 | 8.18e-07 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLS3 | SNV | Missense_Mutation | novel | c.1186N>A | p.Glu396Lys | p.E396K | P13797 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PLS3 | SNV | Missense_Mutation | rs781990552 | c.555G>C | p.Lys185Asn | p.K185N | P13797 | protein_coding | deleterious(0) | possibly_damaging(0.702) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLS3 | SNV | Missense_Mutation | c.46G>A | p.Glu16Lys | p.E16K | P13797 | protein_coding | deleterious(0.04) | benign(0.271) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PLS3 | SNV | Missense_Mutation | c.869N>G | p.Asn290Ser | p.N290S | P13797 | protein_coding | tolerated(0.54) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLS3 | SNV | Missense_Mutation | c.874N>A | p.Phe292Ile | p.F292I | P13797 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PLS3 | SNV | Missense_Mutation | novel | c.569N>T | p.Pro190Leu | p.P190L | P13797 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLS3 | SNV | Missense_Mutation | c.535N>C | p.Asp179His | p.D179H | P13797 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PLS3 | SNV | Missense_Mutation | rs370999829 | c.1262N>T | p.Ala421Val | p.A421V | P13797 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-AA-3667-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLS3 | SNV | Missense_Mutation | rs370999829 | c.1262N>T | p.Ala421Val | p.A421V | P13797 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLS3 | SNV | Missense_Mutation | c.299N>C | p.Lys100Thr | p.K100T | P13797 | protein_coding | tolerated(0.05) | benign(0.15) | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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