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Gene: PIGS |
Gene summary for PIGS |
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Gene information | Species | Human | Gene symbol | PIGS | Gene ID | 94005 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class S | |
Gene Alias | DEE95 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NBL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94005 | PIGS | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.55e-09 | 1.88e-01 | 0.0155 |
94005 | PIGS | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.16e-13 | 3.95e-01 | -0.1808 |
94005 | PIGS | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.92e-17 | 4.70e-01 | -0.0811 |
94005 | PIGS | HTA11_78_2000001011 | Human | Colorectum | AD | 2.42e-13 | 3.59e-01 | -0.1088 |
94005 | PIGS | HTA11_347_2000001011 | Human | Colorectum | AD | 1.20e-28 | 5.22e-01 | -0.1954 |
94005 | PIGS | HTA11_411_2000001011 | Human | Colorectum | SER | 7.44e-09 | 8.27e-01 | -0.2602 |
94005 | PIGS | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-05 | 4.80e-01 | -0.2196 |
94005 | PIGS | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.26e-13 | 3.50e-01 | -0.1207 |
94005 | PIGS | HTA11_83_2000001011 | Human | Colorectum | SER | 7.80e-11 | 3.47e-01 | -0.1526 |
94005 | PIGS | HTA11_696_2000001011 | Human | Colorectum | AD | 2.11e-21 | 3.92e-01 | -0.1464 |
94005 | PIGS | HTA11_866_2000001011 | Human | Colorectum | AD | 8.94e-11 | 2.09e-01 | -0.1001 |
94005 | PIGS | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.87e-19 | 4.31e-01 | -0.059 |
94005 | PIGS | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 4.01e-01 | -0.1706 |
94005 | PIGS | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.57e-15 | 6.02e-01 | -0.2061 |
94005 | PIGS | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.36e-01 | -0.1462 |
94005 | PIGS | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 2.75e-01 | -0.0842 |
94005 | PIGS | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.59e-09 | 3.39e-01 | -0.0179 |
94005 | PIGS | HTA11_866_3004761011 | Human | Colorectum | AD | 1.60e-16 | 3.55e-01 | 0.096 |
94005 | PIGS | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.95e-07 | 3.65e-01 | 0.0528 |
94005 | PIGS | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-08 | 3.59e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19035092 | Esophagus | ESCC | liposaccharide metabolic process | 63/8552 | 101/18723 | 5.25e-04 | 2.90e-03 | 63 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:0009247 | Esophagus | ESCC | glycolipid biosynthetic process | 42/8552 | 68/18723 | 5.48e-03 | 2.05e-02 | 42 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:0042157 | Liver | Cirrhotic | lipoprotein metabolic process | 53/4634 | 135/18723 | 1.32e-04 | 1.29e-03 | 53 |
GO:0006643 | Liver | Cirrhotic | membrane lipid metabolic process | 69/4634 | 203/18723 | 1.89e-03 | 1.19e-02 | 69 |
GO:0042158 | Liver | Cirrhotic | lipoprotein biosynthetic process | 36/4634 | 96/18723 | 3.69e-03 | 2.03e-02 | 36 |
GO:0006497 | Liver | Cirrhotic | protein lipidation | 33/4634 | 92/18723 | 1.12e-02 | 4.92e-02 | 33 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:00421571 | Liver | HCC | lipoprotein metabolic process | 86/7958 | 135/18723 | 5.21e-07 | 8.38e-06 | 86 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:004647411 | Liver | HCC | glycerophospholipid biosynthetic process | 121/7958 | 211/18723 | 9.12e-06 | 1.06e-04 | 121 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:00421581 | Liver | HCC | lipoprotein biosynthetic process | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
GO:00064971 | Liver | HCC | protein lipidation | 55/7958 | 92/18723 | 6.12e-04 | 3.82e-03 | 55 |
GO:0046467 | Liver | HCC | membrane lipid biosynthetic process | 78/7958 | 142/18723 | 1.85e-03 | 9.46e-03 | 78 |
GO:0006664 | Liver | HCC | glycolipid metabolic process | 57/7958 | 100/18723 | 2.40e-03 | 1.17e-02 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005632 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa0056311 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa00563 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
hsa005631 | Liver | HCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 18/4020 | 26/8465 | 2.08e-02 | 4.81e-02 | 2.68e-02 | 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIGS | SNV | Missense_Mutation | novel | c.232N>T | p.Asp78Tyr | p.D78Y | Q96S52 | protein_coding | tolerated(0.08) | possibly_damaging(0.849) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIGS | SNV | Missense_Mutation | c.585G>C | p.Leu195Phe | p.L195F | Q96S52 | protein_coding | tolerated(1) | benign(0.007) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGS | insertion | Frame_Shift_Ins | novel | c.973_974insAGCGGACAAA | p.Leu325GlnfsTer9 | p.L325Qfs*9 | Q96S52 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
PIGS | deletion | Frame_Shift_Del | novel | c.1541delC | p.Pro514LeufsTer73 | p.P514Lfs*73 | Q96S52 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PIGS | SNV | Missense_Mutation | rs372383165 | c.433T>C | p.Tyr145His | p.Y145H | Q96S52 | protein_coding | tolerated(0.06) | probably_damaging(0.915) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PIGS | SNV | Missense_Mutation | c.1145T>C | p.Met382Thr | p.M382T | Q96S52 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGS | SNV | Missense_Mutation | c.860N>G | p.Asp287Gly | p.D287G | Q96S52 | protein_coding | deleterious(0.01) | benign(0.131) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGS | SNV | Missense_Mutation | c.163N>G | p.Asn55Asp | p.N55D | Q96S52 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PIGS | SNV | Missense_Mutation | c.958N>T | p.Pro320Ser | p.P320S | Q96S52 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PIGS | SNV | Missense_Mutation | c.284A>G | p.Lys95Arg | p.K95R | Q96S52 | protein_coding | tolerated(0.11) | possibly_damaging(0.493) | TCGA-EI-6508-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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