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Gene: PGAP3 |
Gene summary for PGAP3 |
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Gene information | Species | Human | Gene symbol | PGAP3 | Gene ID | 93210 |
Gene name | post-GPI attachment to proteins phospholipase 3 | |
Gene Alias | AGLA546 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96FM1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93210 | PGAP3 | GSM4909289 | Human | Breast | IDC | 2.84e-02 | 2.77e-01 | 0.1064 |
93210 | PGAP3 | GSM4909290 | Human | Breast | IDC | 3.86e-35 | 6.86e-01 | 0.2096 |
93210 | PGAP3 | GSM4909291 | Human | Breast | IDC | 1.35e-08 | 3.05e-01 | 0.1753 |
93210 | PGAP3 | GSM4909292 | Human | Breast | IDC | 8.93e-07 | 6.12e-01 | 0.1236 |
93210 | PGAP3 | GSM4909293 | Human | Breast | IDC | 3.95e-52 | 6.53e-01 | 0.1581 |
93210 | PGAP3 | GSM4909294 | Human | Breast | IDC | 1.04e-08 | 2.63e-01 | 0.2022 |
93210 | PGAP3 | NCCBC14 | Human | Breast | DCIS | 6.80e-03 | 2.87e-01 | 0.2021 |
93210 | PGAP3 | NCCBC5 | Human | Breast | DCIS | 4.33e-07 | 4.00e-01 | 0.2046 |
93210 | PGAP3 | DCIS2 | Human | Breast | DCIS | 8.67e-03 | 2.01e-02 | 0.0085 |
93210 | PGAP3 | LZE4T | Human | Esophagus | ESCC | 4.81e-06 | 9.06e-02 | 0.0811 |
93210 | PGAP3 | LZE7T | Human | Esophagus | ESCC | 6.72e-04 | 2.22e-01 | 0.0667 |
93210 | PGAP3 | LZE24T | Human | Esophagus | ESCC | 2.30e-07 | 2.49e-01 | 0.0596 |
93210 | PGAP3 | P1T-E | Human | Esophagus | ESCC | 7.29e-06 | 1.61e-01 | 0.0875 |
93210 | PGAP3 | P2T-E | Human | Esophagus | ESCC | 8.91e-20 | 1.80e-01 | 0.1177 |
93210 | PGAP3 | P4T-E | Human | Esophagus | ESCC | 1.47e-13 | 1.09e-01 | 0.1323 |
93210 | PGAP3 | P5T-E | Human | Esophagus | ESCC | 7.51e-04 | 3.55e-02 | 0.1327 |
93210 | PGAP3 | P8T-E | Human | Esophagus | ESCC | 1.15e-17 | 3.34e-01 | 0.0889 |
93210 | PGAP3 | P9T-E | Human | Esophagus | ESCC | 9.72e-09 | 9.44e-02 | 0.1131 |
93210 | PGAP3 | P10T-E | Human | Esophagus | ESCC | 2.29e-10 | 1.37e-01 | 0.116 |
93210 | PGAP3 | P11T-E | Human | Esophagus | ESCC | 1.68e-08 | 2.05e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00086543 | Oral cavity | OSCC | phospholipid biosynthetic process | 130/7305 | 253/18723 | 3.96e-05 | 3.46e-04 | 130 |
GO:00421582 | Oral cavity | OSCC | lipoprotein biosynthetic process | 57/7305 | 96/18723 | 4.17e-05 | 3.61e-04 | 57 |
GO:00464672 | Oral cavity | OSCC | membrane lipid biosynthetic process | 77/7305 | 142/18723 | 1.63e-04 | 1.13e-03 | 77 |
GO:00065062 | Oral cavity | OSCC | GPI anchor biosynthetic process | 21/7305 | 32/18723 | 2.08e-03 | 9.59e-03 | 21 |
GO:00066641 | Oral cavity | OSCC | glycolipid metabolic process | 53/7305 | 100/18723 | 3.09e-03 | 1.33e-02 | 53 |
GO:00464743 | Oral cavity | OSCC | glycerophospholipid biosynthetic process | 102/7305 | 211/18723 | 3.50e-03 | 1.48e-02 | 102 |
GO:00065052 | Oral cavity | OSCC | GPI anchor metabolic process | 21/7305 | 33/18723 | 3.63e-03 | 1.51e-02 | 21 |
GO:19035091 | Oral cavity | OSCC | liposaccharide metabolic process | 53/7305 | 101/18723 | 4.06e-03 | 1.66e-02 | 53 |
GO:00066445 | Oral cavity | OSCC | phospholipid metabolic process | 175/7305 | 383/18723 | 4.21e-03 | 1.71e-02 | 175 |
GO:004215711 | Oral cavity | LP | lipoprotein metabolic process | 57/4623 | 135/18723 | 5.59e-06 | 1.11e-04 | 57 |
GO:000649711 | Oral cavity | LP | protein lipidation | 40/4623 | 92/18723 | 6.04e-05 | 8.20e-04 | 40 |
GO:004215811 | Oral cavity | LP | lipoprotein biosynthetic process | 41/4623 | 96/18723 | 8.04e-05 | 1.04e-03 | 41 |
GO:00065061 | Oral cavity | LP | GPI anchor biosynthetic process | 18/4623 | 32/18723 | 1.33e-04 | 1.54e-03 | 18 |
GO:00065051 | Oral cavity | LP | GPI anchor metabolic process | 18/4623 | 33/18723 | 2.26e-04 | 2.41e-03 | 18 |
GO:000664311 | Oral cavity | LP | membrane lipid metabolic process | 69/4623 | 203/18723 | 1.77e-03 | 1.34e-02 | 69 |
GO:00464671 | Oral cavity | LP | membrane lipid biosynthetic process | 49/4623 | 142/18723 | 5.44e-03 | 3.31e-02 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PGAP3 | SNV | Missense_Mutation | rs760427744 | c.194N>A | p.Arg65Gln | p.R65Q | Q96FM1 | protein_coding | tolerated(0.35) | benign(0.011) | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD |
PGAP3 | insertion | Frame_Shift_Ins | novel | c.944_945insGTGCTCCATAACGCCTGGA | p.Asp315GlufsTer101 | p.D315Efs*101 | Q96FM1 | protein_coding | TCGA-AR-A24U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
PGAP3 | SNV | Missense_Mutation | c.665N>T | p.Gly222Val | p.G222V | Q96FM1 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PGAP3 | SNV | Missense_Mutation | rs532257048 | c.808N>A | p.Glu270Lys | p.E270K | Q96FM1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A9UP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PGAP3 | SNV | Missense_Mutation | novel | c.468N>G | p.Phe156Leu | p.F156L | Q96FM1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PGAP3 | SNV | Missense_Mutation | c.215G>A | p.Cys72Tyr | p.C72Y | Q96FM1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PGAP3 | SNV | Missense_Mutation | c.665N>A | p.Gly222Asp | p.G222D | Q96FM1 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PGAP3 | SNV | Missense_Mutation | rs369388252 | c.886N>A | p.Val296Ile | p.V296I | Q96FM1 | protein_coding | tolerated(0.41) | benign(0.028) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PGAP3 | SNV | Missense_Mutation | rs752623171 | c.325N>A | p.Val109Met | p.V109M | Q96FM1 | protein_coding | tolerated(0.2) | benign(0.034) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PGAP3 | SNV | Missense_Mutation | c.160C>T | p.Pro54Ser | p.P54S | Q96FM1 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-CI-6619-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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