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Gene: PFDN1 |
Gene summary for PFDN1 |
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Gene information | Species | Human | Gene symbol | PFDN1 | Gene ID | 5201 |
Gene name | prefoldin subunit 1 | |
Gene Alias | ||
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | O60925 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5201 | PFDN1 | LZE2T | Human | Esophagus | ESCC | 1.93e-06 | 4.94e-01 | 0.082 |
5201 | PFDN1 | LZE4T | Human | Esophagus | ESCC | 2.22e-12 | 2.83e-01 | 0.0811 |
5201 | PFDN1 | LZE5T | Human | Esophagus | ESCC | 9.54e-03 | 5.79e-01 | 0.0514 |
5201 | PFDN1 | LZE7T | Human | Esophagus | ESCC | 6.75e-10 | 5.28e-01 | 0.0667 |
5201 | PFDN1 | LZE8T | Human | Esophagus | ESCC | 9.24e-07 | 1.89e-01 | 0.067 |
5201 | PFDN1 | LZE22T | Human | Esophagus | ESCC | 7.88e-09 | 6.20e-01 | 0.068 |
5201 | PFDN1 | LZE24T | Human | Esophagus | ESCC | 1.66e-21 | 5.41e-01 | 0.0596 |
5201 | PFDN1 | LZE21T | Human | Esophagus | ESCC | 3.69e-02 | 2.71e-01 | 0.0655 |
5201 | PFDN1 | LZE6T | Human | Esophagus | ESCC | 7.33e-14 | 5.50e-01 | 0.0845 |
5201 | PFDN1 | P1T-E | Human | Esophagus | ESCC | 8.02e-09 | 4.70e-01 | 0.0875 |
5201 | PFDN1 | P2T-E | Human | Esophagus | ESCC | 2.83e-34 | 5.37e-01 | 0.1177 |
5201 | PFDN1 | P4T-E | Human | Esophagus | ESCC | 7.14e-26 | 5.38e-01 | 0.1323 |
5201 | PFDN1 | P5T-E | Human | Esophagus | ESCC | 2.19e-33 | 5.99e-01 | 0.1327 |
5201 | PFDN1 | P8T-E | Human | Esophagus | ESCC | 1.09e-29 | 5.68e-01 | 0.0889 |
5201 | PFDN1 | P9T-E | Human | Esophagus | ESCC | 1.27e-19 | 4.74e-01 | 0.1131 |
5201 | PFDN1 | P10T-E | Human | Esophagus | ESCC | 1.50e-32 | 4.73e-01 | 0.116 |
5201 | PFDN1 | P11T-E | Human | Esophagus | ESCC | 3.74e-26 | 9.97e-01 | 0.1426 |
5201 | PFDN1 | P12T-E | Human | Esophagus | ESCC | 1.16e-46 | 9.38e-01 | 0.1122 |
5201 | PFDN1 | P15T-E | Human | Esophagus | ESCC | 1.78e-28 | 6.17e-01 | 0.1149 |
5201 | PFDN1 | P16T-E | Human | Esophagus | ESCC | 9.82e-24 | 3.44e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19900009 | Oral cavity | OSCC | amyloid fibril formation | 21/7305 | 34/18723 | 6.02e-03 | 2.28e-02 | 21 |
GO:190290417 | Oral cavity | OSCC | negative regulation of supramolecular fiber organization | 81/7305 | 167/18723 | 7.70e-03 | 2.82e-02 | 81 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:1902903110 | Oral cavity | LP | regulation of supramolecular fiber organization | 131/4623 | 383/18723 | 1.58e-05 | 2.78e-04 | 131 |
GO:190590615 | Oral cavity | LP | regulation of amyloid fibril formation | 12/4623 | 16/18723 | 3.30e-05 | 5.02e-04 | 12 |
GO:190590715 | Oral cavity | LP | negative regulation of amyloid fibril formation | 10/4623 | 13/18723 | 1.12e-04 | 1.34e-03 | 10 |
GO:199000016 | Oral cavity | LP | amyloid fibril formation | 18/4623 | 34/18723 | 3.69e-04 | 3.64e-03 | 18 |
GO:190290418 | Oral cavity | LP | negative regulation of supramolecular fiber organization | 56/4623 | 167/18723 | 6.19e-03 | 3.66e-02 | 56 |
GO:190290318 | Prostate | BPH | regulation of supramolecular fiber organization | 133/3107 | 383/18723 | 2.40e-18 | 8.73e-16 | 133 |
GO:000645716 | Prostate | BPH | protein folding | 85/3107 | 212/18723 | 2.37e-16 | 4.74e-14 | 85 |
GO:190290410 | Prostate | BPH | negative regulation of supramolecular fiber organization | 55/3107 | 167/18723 | 1.60e-07 | 3.63e-06 | 55 |
GO:19059066 | Prostate | BPH | regulation of amyloid fibril formation | 10/3107 | 16/18723 | 4.73e-05 | 4.95e-04 | 10 |
GO:19059076 | Prostate | BPH | negative regulation of amyloid fibril formation | 8/3107 | 13/18723 | 3.33e-04 | 2.52e-03 | 8 |
GO:19900008 | Prostate | BPH | amyloid fibril formation | 14/3107 | 34/18723 | 5.89e-04 | 4.08e-03 | 14 |
GO:190290319 | Prostate | Tumor | regulation of supramolecular fiber organization | 131/3246 | 383/18723 | 6.68e-16 | 1.26e-13 | 131 |
GO:000645717 | Prostate | Tumor | protein folding | 85/3246 | 212/18723 | 3.37e-15 | 5.37e-13 | 85 |
GO:190290416 | Prostate | Tumor | negative regulation of supramolecular fiber organization | 54/3246 | 167/18723 | 1.64e-06 | 2.90e-05 | 54 |
GO:190590614 | Prostate | Tumor | regulation of amyloid fibril formation | 10/3246 | 16/18723 | 6.99e-05 | 7.41e-04 | 10 |
GO:190590714 | Prostate | Tumor | negative regulation of amyloid fibril formation | 8/3246 | 13/18723 | 4.54e-04 | 3.43e-03 | 8 |
GO:199000015 | Prostate | Tumor | amyloid fibril formation | 14/3246 | 34/18723 | 9.26e-04 | 6.10e-03 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFDN1 | SNV | Missense_Mutation | c.43N>C | p.Glu15Gln | p.E15Q | O60925 | protein_coding | tolerated(0.05) | possibly_damaging(0.566) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PFDN1 | SNV | Missense_Mutation | c.185N>G | p.Glu62Gly | p.E62G | O60925 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PFDN1 | SNV | Missense_Mutation | rs763185306 | c.119C>T | p.Thr40Met | p.T40M | O60925 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | c.80T>C | p.Val27Ala | p.V27A | O60925 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFDN1 | SNV | Missense_Mutation | rs757466775 | c.313N>A | p.Val105Ile | p.V105I | O60925 | protein_coding | tolerated(0.2) | benign(0.048) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | novel | c.52N>T | p.Ala18Ser | p.A18S | O60925 | protein_coding | tolerated(0.34) | benign(0.062) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | c.197G>T | p.Arg66Ile | p.R66I | O60925 | protein_coding | deleterious(0.02) | benign(0.376) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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