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Gene: PDIA6 |
Gene summary for PDIA6 |
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Gene information | Species | Human | Gene symbol | PDIA6 | Gene ID | 10130 |
Gene name | protein disulfide isomerase family A member 6 | |
Gene Alias | ERP5 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q15084 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10130 | PDIA6 | GSM4909281 | Human | Breast | IDC | 2.50e-22 | 6.06e-01 | 0.21 |
10130 | PDIA6 | GSM4909285 | Human | Breast | IDC | 3.42e-40 | 7.61e-01 | 0.21 |
10130 | PDIA6 | GSM4909287 | Human | Breast | IDC | 2.53e-07 | 3.38e-01 | 0.2057 |
10130 | PDIA6 | GSM4909288 | Human | Breast | IDC | 1.81e-04 | 2.15e-01 | 0.0988 |
10130 | PDIA6 | GSM4909294 | Human | Breast | IDC | 2.31e-04 | -2.38e-01 | 0.2022 |
10130 | PDIA6 | GSM4909296 | Human | Breast | IDC | 8.05e-18 | -3.54e-01 | 0.1524 |
10130 | PDIA6 | GSM4909297 | Human | Breast | IDC | 3.64e-14 | -2.01e-01 | 0.1517 |
10130 | PDIA6 | GSM4909298 | Human | Breast | IDC | 9.62e-04 | -2.35e-01 | 0.1551 |
10130 | PDIA6 | GSM4909301 | Human | Breast | IDC | 1.75e-04 | -2.11e-01 | 0.1577 |
10130 | PDIA6 | GSM4909307 | Human | Breast | IDC | 2.73e-02 | -2.42e-01 | 0.1569 |
10130 | PDIA6 | GSM4909311 | Human | Breast | IDC | 7.23e-43 | -3.53e-01 | 0.1534 |
10130 | PDIA6 | GSM4909312 | Human | Breast | IDC | 5.10e-17 | 3.09e-04 | 0.1552 |
10130 | PDIA6 | GSM4909313 | Human | Breast | IDC | 4.76e-02 | -7.16e-02 | 0.0391 |
10130 | PDIA6 | GSM4909316 | Human | Breast | IDC | 6.49e-03 | -3.87e-02 | 0.21 |
10130 | PDIA6 | GSM4909317 | Human | Breast | IDC | 4.40e-08 | 3.92e-01 | 0.1355 |
10130 | PDIA6 | GSM4909319 | Human | Breast | IDC | 8.08e-47 | -3.67e-01 | 0.1563 |
10130 | PDIA6 | GSM4909320 | Human | Breast | IDC | 1.53e-09 | -3.05e-01 | 0.1575 |
10130 | PDIA6 | GSM4909321 | Human | Breast | IDC | 2.64e-19 | -1.04e-02 | 0.1559 |
10130 | PDIA6 | brca2 | Human | Breast | Precancer | 2.46e-09 | 3.64e-01 | -0.024 |
10130 | PDIA6 | M2 | Human | Breast | IDC | 8.13e-07 | 4.40e-02 | 0.21 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645731 | Stomach | CAG | protein folding | 36/552 | 212/18723 | 1.36e-17 | 3.03e-14 | 36 |
GO:000645741 | Stomach | WIM | protein folding | 28/426 | 212/18723 | 6.19e-14 | 8.17e-11 | 28 |
GO:00064575 | Stomach | SIM | protein folding | 39/708 | 212/18723 | 1.60e-16 | 1.08e-13 | 39 |
GO:000645727 | Thyroid | HT | protein folding | 45/1272 | 212/18723 | 5.29e-12 | 1.01e-09 | 45 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
GO:000645728 | Thyroid | goiters | protein folding | 33/497 | 212/18723 | 2.09e-16 | 8.64e-14 | 33 |
GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414144 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0414154 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDIA6 | SNV | Missense_Mutation | novel | c.70C>T | p.Arg24Cys | p.R24C | Q15084 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDIA6 | SNV | Missense_Mutation | novel | c.136N>G | p.Pro46Ala | p.P46A | Q15084 | protein_coding | tolerated_low_confidence(0.28) | benign(0) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
PDIA6 | SNV | Missense_Mutation | rs373388851 | c.713A>G | p.Tyr238Cys | p.Y238C | Q15084 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.788N>T | p.Thr263Met | p.T263M | Q15084 | protein_coding | tolerated(0.2) | probably_damaging(0.93) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PDIA6 | SNV | Missense_Mutation | novel | c.241G>A | p.Glu81Lys | p.E81K | Q15084 | protein_coding | tolerated(0.1) | benign(0.17) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.458T>C | p.Ile153Thr | p.I153T | Q15084 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDIA6 | SNV | Missense_Mutation | rs775783522 | c.581N>A | p.Arg194Gln | p.R194Q | Q15084 | protein_coding | tolerated(0.06) | benign(0.065) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDIA6 | SNV | Missense_Mutation | c.541N>G | p.Ser181Gly | p.S181G | Q15084 | protein_coding | tolerated(0.2) | benign(0.044) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDIA6 | SNV | Missense_Mutation | rs138012463 | c.1249C>T | p.Arg417Cys | p.R417C | Q15084 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
PDIA6 | SNV | Missense_Mutation | c.707N>C | p.Glu236Ala | p.E236A | Q15084 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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