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Gene: PDE9A |
Gene summary for PDE9A |
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Gene information | Species | Human | Gene symbol | PDE9A | Gene ID | 5152 |
Gene name | phosphodiesterase 9A | |
Gene Alias | HSPDE9A2 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A0S2Z4A3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5152 | PDE9A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.30e-18 | -6.84e-01 | 0.0155 |
5152 | PDE9A | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.95e-07 | -5.51e-02 | -0.2196 |
5152 | PDE9A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.50e-03 | -5.29e-01 | 0.0588 |
5152 | PDE9A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.98e-25 | -7.03e-01 | 0.294 |
5152 | PDE9A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.90e-12 | -7.93e-01 | 0.281 |
5152 | PDE9A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.21e-14 | -5.48e-01 | 0.3859 |
5152 | PDE9A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.85e-12 | -8.67e-01 | 0.2585 |
5152 | PDE9A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.45e-22 | -7.02e-01 | 0.3005 |
5152 | PDE9A | F007 | Human | Colorectum | FAP | 2.06e-20 | -8.16e-01 | 0.1176 |
5152 | PDE9A | A002-C-010 | Human | Colorectum | FAP | 1.29e-17 | -5.72e-01 | 0.242 |
5152 | PDE9A | A001-C-207 | Human | Colorectum | FAP | 5.45e-15 | -6.03e-01 | 0.1278 |
5152 | PDE9A | A015-C-203 | Human | Colorectum | FAP | 1.88e-31 | -5.42e-01 | -0.1294 |
5152 | PDE9A | A015-C-204 | Human | Colorectum | FAP | 4.08e-15 | -5.97e-01 | -0.0228 |
5152 | PDE9A | A014-C-040 | Human | Colorectum | FAP | 1.37e-07 | -5.77e-01 | -0.1184 |
5152 | PDE9A | A002-C-201 | Human | Colorectum | FAP | 4.94e-27 | -6.71e-01 | 0.0324 |
5152 | PDE9A | A002-C-203 | Human | Colorectum | FAP | 2.13e-11 | -4.75e-01 | 0.2786 |
5152 | PDE9A | A001-C-119 | Human | Colorectum | FAP | 6.35e-09 | -4.88e-01 | -0.1557 |
5152 | PDE9A | A001-C-108 | Human | Colorectum | FAP | 4.73e-18 | -4.42e-01 | -0.0272 |
5152 | PDE9A | A002-C-205 | Human | Colorectum | FAP | 4.87e-33 | -7.18e-01 | -0.1236 |
5152 | PDE9A | A001-C-104 | Human | Colorectum | FAP | 1.10e-05 | -2.83e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00196931 | Colorectum | SER | ribose phosphate metabolic process | 105/2897 | 396/18723 | 8.15e-09 | 7.14e-07 | 105 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:00902571 | Colorectum | SER | regulation of muscle system process | 60/2897 | 252/18723 | 3.28e-04 | 5.22e-03 | 60 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00346551 | Colorectum | SER | nucleobase-containing compound catabolic process | 88/2897 | 407/18723 | 5.53e-04 | 7.71e-03 | 88 |
GO:00194391 | Colorectum | SER | aromatic compound catabolic process | 98/2897 | 467/18723 | 8.09e-04 | 1.01e-02 | 98 |
GO:00061951 | Colorectum | SER | purine nucleotide catabolic process | 16/2897 | 46/18723 | 9.88e-04 | 1.17e-02 | 16 |
GO:00725231 | Colorectum | SER | purine-containing compound catabolic process | 17/2897 | 52/18723 | 1.53e-03 | 1.64e-02 | 17 |
GO:00435021 | Colorectum | SER | regulation of muscle adaptation | 27/2897 | 98/18723 | 1.54e-03 | 1.65e-02 | 27 |
GO:0043500 | Colorectum | SER | muscle adaptation | 31/2897 | 121/18723 | 2.58e-03 | 2.38e-02 | 31 |
GO:0003012 | Colorectum | SER | muscle system process | 92/2897 | 452/18723 | 2.98e-03 | 2.63e-02 | 92 |
GO:0009166 | Colorectum | SER | nucleotide catabolic process | 20/2897 | 73/18723 | 6.34e-03 | 4.56e-02 | 20 |
GO:00061632 | Colorectum | MSS | purine nucleotide metabolic process | 128/3467 | 396/18723 | 2.04e-11 | 3.02e-09 | 128 |
GO:00091502 | Colorectum | MSS | purine ribonucleotide metabolic process | 121/3467 | 368/18723 | 2.08e-11 | 3.02e-09 | 121 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE9A | SNV | Missense_Mutation | novel | c.926N>C | p.Asn309Thr | p.N309T | O76083 | protein_coding | tolerated(0.41) | possibly_damaging(0.662) | TCGA-AC-A23E-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
PDE9A | SNV | Missense_Mutation | rs765570911 | c.1127N>G | p.Asn376Ser | p.N376S | O76083 | protein_coding | deleterious(0.02) | probably_damaging(0.932) | TCGA-BH-A1EU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE9A | SNV | Missense_Mutation | rs188819062 | c.787G>A | p.Val263Ile | p.V263I | O76083 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-LL-A50Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | CR |
PDE9A | deletion | Frame_Shift_Del | c.240delN | p.Val81TrpfsTer26 | p.V81Wfs*26 | O76083 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PDE9A | SNV | Missense_Mutation | rs770883595 | c.205N>A | p.Ala69Thr | p.A69T | O76083 | protein_coding | tolerated(0.32) | benign(0.015) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDE9A | SNV | Missense_Mutation | rs781169820 | c.1280G>T | p.Arg427Ile | p.R427I | O76083 | protein_coding | deleterious(0) | benign(0.1) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PDE9A | SNV | Missense_Mutation | novel | c.1136N>T | p.Ser379Leu | p.S379L | O76083 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PDE9A | SNV | Missense_Mutation | rs766492657 | c.712N>T | p.Arg238Cys | p.R238C | O76083 | protein_coding | deleterious(0.02) | benign(0.037) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PDE9A | SNV | Missense_Mutation | rs139833833 | c.431N>A | p.Arg144His | p.R144H | O76083 | protein_coding | tolerated(0.26) | benign(0.031) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDE9A | SNV | Missense_Mutation | c.1518A>C | p.Lys506Asn | p.K506N | O76083 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5152 | PDE9A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
5152 | PDE9A | DRUGGABLE GENOME, ENZYME | inhibitor | 135651355 | ZAPRINAST | |
5152 | PDE9A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL932 | DIPYRIDAMOLE | |
5152 | PDE9A | DRUGGABLE GENOME, ENZYME | inhibitor | 178101953 |
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