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Gene: PDE5A |
Gene summary for PDE5A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PDE5A | Gene ID | 8654 |
| Gene name | phosphodiesterase 5A | |
| Gene Alias | CGB-PDE | |
| Cytomap | 4q26 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O76074 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8654 | PDE5A | HTA12-15-2 | Human | Pancreas | PDAC | 1.52e-02 | 3.53e-01 | 0.2315 |
| 8654 | PDE5A | HTA12-26-1 | Human | Pancreas | PDAC | 2.29e-06 | 5.26e-01 | 0.3728 |
| 8654 | PDE5A | HTA12-29-1 | Human | Pancreas | PDAC | 3.37e-25 | 7.06e-01 | 0.3722 |
| 8654 | PDE5A | male-WTA | Human | Thyroid | PTC | 1.89e-51 | 6.76e-01 | 0.1037 |
| 8654 | PDE5A | PTC01 | Human | Thyroid | PTC | 2.98e-48 | 1.02e+00 | 0.1899 |
| 8654 | PDE5A | PTC03 | Human | Thyroid | PTC | 7.43e-17 | 9.76e-01 | 0.1784 |
| 8654 | PDE5A | PTC04 | Human | Thyroid | PTC | 2.02e-52 | 1.00e+00 | 0.1927 |
| 8654 | PDE5A | PTC05 | Human | Thyroid | PTC | 3.76e-62 | 2.54e+00 | 0.2065 |
| 8654 | PDE5A | PTC06 | Human | Thyroid | PTC | 2.80e-93 | 2.40e+00 | 0.2057 |
| 8654 | PDE5A | PTC07 | Human | Thyroid | PTC | 2.54e-102 | 1.79e+00 | 0.2044 |
| 8654 | PDE5A | ATC13 | Human | Thyroid | ATC | 7.30e-10 | 1.85e-01 | 0.34 |
| 8654 | PDE5A | ATC5 | Human | Thyroid | ATC | 6.33e-12 | 2.04e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
| GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
| GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
| GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
| GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
| GO:00725232 | Thyroid | ATC | purine-containing compound catabolic process | 26/6293 | 52/18723 | 1.05e-02 | 3.82e-02 | 26 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PDE5A | SNV | Missense_Mutation | c.2509N>A | p.Glu837Lys | p.E837K | O76074 | protein_coding | tolerated(0.1) | benign(0.358) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
| PDE5A | SNV | Missense_Mutation | novel | c.1570G>C | p.Glu524Gln | p.E524Q | O76074 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| PDE5A | SNV | Missense_Mutation | c.326N>G | p.Pro109Arg | p.P109R | O76074 | protein_coding | tolerated(0.11) | benign(0.062) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
| PDE5A | SNV | Missense_Mutation | c.287C>A | p.Thr96Lys | p.T96K | O76074 | protein_coding | deleterious(0) | benign(0.046) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| PDE5A | SNV | Missense_Mutation | c.472N>T | p.Asp158Tyr | p.D158Y | O76074 | protein_coding | deleterious(0) | possibly_damaging(0.556) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| PDE5A | SNV | Missense_Mutation | rs200355800 | c.1465G>A | p.Glu489Lys | p.E489K | O76074 | protein_coding | deleterious(0.03) | possibly_damaging(0.529) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PDE5A | SNV | Missense_Mutation | c.1073N>C | p.Ile358Thr | p.I358T | O76074 | protein_coding | tolerated(0.58) | benign(0.019) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| PDE5A | SNV | Missense_Mutation | c.1625C>T | p.Ser542Leu | p.S542L | O76074 | protein_coding | tolerated(0.28) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PDE5A | SNV | Missense_Mutation | c.430N>T | p.Asp144Tyr | p.D144Y | O76074 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| PDE5A | SNV | Missense_Mutation | c.153A>C | p.Arg51Ser | p.R51S | O76074 | protein_coding | tolerated(0.05) | benign(0.013) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | 178101953 | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | ICARIIN | ICARIIN | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | PENTOXIFYLLINE | PENTOXIFYLLINE | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | AVANAFIL | AVANAFIL | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | ENALAPRIL | ENALAPRIL | 15452190 | |
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | Udenafil | UDENAFIL | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | UK-371800 | CHEMBL460293 | ||
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1963681 | AVANAFIL | |
| 8654 | PDE5A | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1339 | VARDENAFIL HYDROCHLORIDE |
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