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Gene: PCSK5 |
Gene summary for PCSK5 |
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Gene information | Species | Human | Gene symbol | PCSK5 | Gene ID | 5125 |
Gene name | proprotein convertase subtilisin/kexin type 5 | |
Gene Alias | PC5 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q92824 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5125 | PCSK5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.06e-51 | -1.22e+00 | 0.0155 |
5125 | PCSK5 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.25e-06 | -1.09e+00 | 0.0216 |
5125 | PCSK5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.44e-11 | -6.95e-01 | -0.0811 |
5125 | PCSK5 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.71e-03 | -1.35e-01 | -0.1088 |
5125 | PCSK5 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.35e-36 | 1.24e+00 | -0.1954 |
5125 | PCSK5 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.13e-02 | 4.30e-01 | -0.1526 |
5125 | PCSK5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.25e-03 | 3.50e-02 | -0.1464 |
5125 | PCSK5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.35e-02 | -5.94e-01 | -0.00410000000000005 |
5125 | PCSK5 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.24e-32 | -1.04e+00 | 0.096 |
5125 | PCSK5 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.83e-07 | -1.12e+00 | 0.0451 |
5125 | PCSK5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.33e-07 | -9.56e-01 | 0.0528 |
5125 | PCSK5 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.10e-17 | -9.34e-01 | 0.0338 |
5125 | PCSK5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.36e-71 | -1.22e+00 | 0.0674 |
5125 | PCSK5 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.34e-13 | -9.85e-01 | 0.0112 |
5125 | PCSK5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 5.71e-26 | -1.19e+00 | 0.0588 |
5125 | PCSK5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.14e-57 | -1.12e+00 | 0.294 |
5125 | PCSK5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.20e-02 | -8.59e-01 | 0.3487 |
5125 | PCSK5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.70e-25 | -9.11e-01 | 0.281 |
5125 | PCSK5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.09e-34 | -9.05e-01 | 0.3859 |
5125 | PCSK5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.93e-22 | -1.28e+00 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487361 | Colorectum | SER | appendage development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00601731 | Colorectum | SER | limb development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
GO:00064651 | Colorectum | SER | signal peptide processing | 7/2897 | 14/18723 | 2.64e-03 | 2.41e-02 | 7 |
GO:0035107 | Colorectum | SER | appendage morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
GO:0035108 | Colorectum | SER | limb morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00190582 | Colorectum | MSS | viral life cycle | 111/3467 | 317/18723 | 1.65e-12 | 2.95e-10 | 111 |
GO:00064652 | Colorectum | MSS | signal peptide processing | 11/3467 | 14/18723 | 1.81e-06 | 5.70e-05 | 11 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:00164852 | Colorectum | MSS | protein processing | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:0001655 | Colorectum | MSS | urogenital system development | 81/3467 | 338/18723 | 6.88e-03 | 4.43e-02 | 81 |
GO:00160323 | Colorectum | MSI-H | viral process | 74/1319 | 415/18723 | 8.87e-14 | 2.05e-11 | 74 |
GO:00190583 | Colorectum | MSI-H | viral life cycle | 53/1319 | 317/18723 | 3.27e-09 | 4.32e-07 | 53 |
GO:00064653 | Colorectum | MSI-H | signal peptide processing | 7/1319 | 14/18723 | 1.87e-05 | 7.82e-04 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK5 | SNV | Missense_Mutation | novel | c.5425N>C | p.Glu1809Gln | p.E1809Q | Q92824 | protein_coding | tolerated(0.06) | benign(0.198) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PCSK5 | SNV | Missense_Mutation | rs752780597 | c.4225A>G | p.Thr1409Ala | p.T1409A | Q92824 | protein_coding | tolerated(0.29) | benign(0.162) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK5 | SNV | Missense_Mutation | rs763309564 | c.1391N>A | p.Arg464Gln | p.R464Q | Q92824 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | |
PCSK5 | SNV | Missense_Mutation | novel | c.2485N>A | p.Glu829Lys | p.E829K | Q92824 | protein_coding | deleterious(0.03) | benign(0.039) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCSK5 | SNV | Missense_Mutation | c.2609G>C | p.Gly870Ala | p.G870A | Q92824 | protein_coding | deleterious(0.01) | possibly_damaging(0.643) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PCSK5 | SNV | Missense_Mutation | c.471N>C | p.Lys157Asn | p.K157N | Q92824 | protein_coding | deleterious(0) | benign(0.313) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PCSK5 | SNV | Missense_Mutation | c.1817N>G | p.Thr606Ser | p.T606S | Q92824 | protein_coding | tolerated(0.18) | benign(0.029) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PCSK5 | SNV | Missense_Mutation | rs373649072 | c.2213N>A | p.Arg738Gln | p.R738Q | Q92824 | protein_coding | deleterious(0.02) | probably_damaging(0.915) | TCGA-E2-A1IE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
PCSK5 | SNV | Missense_Mutation | c.2276G>C | p.Gly759Ala | p.G759A | Q92824 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PCSK5 | insertion | Frame_Shift_Ins | novel | c.3960_3961insCAATTCTCCTGTCTCAGCCTCCCGAGTAGCT | p.Gly1321GlnfsTer26 | p.G1321Qfs*26 | Q92824 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5125 | PCSK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178103178 | ||
5125 | PCSK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166868 |
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