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Gene: PCOLCE |
Gene summary for PCOLCE |
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Gene information | Species | Human | Gene symbol | PCOLCE | Gene ID | 5118 |
Gene name | procollagen C-endopeptidase enhancer | |
Gene Alias | PCPE | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q15113 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5118 | PCOLCE | AEH-subject1 | Human | Endometrium | AEH | 3.55e-42 | -9.55e-01 | -0.3059 |
5118 | PCOLCE | AEH-subject2 | Human | Endometrium | AEH | 4.25e-43 | -9.34e-01 | -0.2525 |
5118 | PCOLCE | AEH-subject3 | Human | Endometrium | AEH | 1.46e-39 | -9.17e-01 | -0.2576 |
5118 | PCOLCE | AEH-subject4 | Human | Endometrium | AEH | 3.28e-24 | -8.09e-01 | -0.2657 |
5118 | PCOLCE | AEH-subject5 | Human | Endometrium | AEH | 1.40e-45 | -9.72e-01 | -0.2953 |
5118 | PCOLCE | EEC-subject1 | Human | Endometrium | EEC | 4.28e-49 | -9.79e-01 | -0.2682 |
5118 | PCOLCE | EEC-subject2 | Human | Endometrium | EEC | 2.52e-56 | -1.01e+00 | -0.2607 |
5118 | PCOLCE | EEC-subject3 | Human | Endometrium | EEC | 8.54e-55 | -9.84e-01 | -0.2525 |
5118 | PCOLCE | EEC-subject4 | Human | Endometrium | EEC | 1.87e-40 | -9.27e-01 | -0.2571 |
5118 | PCOLCE | EEC-subject5 | Human | Endometrium | EEC | 3.06e-50 | -9.79e-01 | -0.249 |
5118 | PCOLCE | GSM5276935 | Human | Endometrium | EEC | 2.72e-46 | -9.72e-01 | -0.123 |
5118 | PCOLCE | GSM5276937 | Human | Endometrium | EEC | 6.56e-10 | -4.34e-01 | -0.0897 |
5118 | PCOLCE | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.05e-36 | -9.06e-01 | -0.1869 |
5118 | PCOLCE | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.74e-36 | -9.56e-01 | -0.1875 |
5118 | PCOLCE | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 8.15e-41 | -9.24e-01 | -0.1883 |
5118 | PCOLCE | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.50e-51 | -9.81e-01 | -0.1934 |
5118 | PCOLCE | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.29e-57 | -1.01e+00 | -0.1917 |
5118 | PCOLCE | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.38e-64 | -1.02e+00 | -0.1916 |
5118 | PCOLCE | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 7.11e-17 | -6.94e-01 | -0.1269 |
5118 | PCOLCE | LZE24T | Human | Esophagus | ESCC | 8.59e-04 | 7.29e-02 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010952112 | Skin | SCCIS | positive regulation of peptidase activity | 21/919 | 197/18723 | 7.07e-04 | 1.01e-02 | 21 |
GO:004586229 | Skin | cSCC | positive regulation of proteolysis | 169/4864 | 372/18723 | 2.43e-16 | 2.21e-14 | 169 |
GO:005254728 | Skin | cSCC | regulation of peptidase activity | 177/4864 | 461/18723 | 2.21e-09 | 8.02e-08 | 177 |
GO:001095227 | Skin | cSCC | positive regulation of peptidase activity | 85/4864 | 197/18723 | 1.14e-07 | 2.69e-06 | 85 |
GO:004586234 | Thyroid | ATC | positive regulation of proteolysis | 202/6293 | 372/18723 | 1.07e-16 | 9.42e-15 | 202 |
GO:005254734 | Thyroid | ATC | regulation of peptidase activity | 200/6293 | 461/18723 | 6.25e-06 | 6.52e-05 | 200 |
GO:001095233 | Thyroid | ATC | positive regulation of peptidase activity | 94/6293 | 197/18723 | 2.67e-05 | 2.28e-04 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCOLCE | SNV | Missense_Mutation | novel | c.126N>T | p.Lys42Asn | p.K42N | Q15113 | protein_coding | deleterious(0.05) | benign(0.001) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PCOLCE | SNV | Missense_Mutation | c.211N>A | p.Glu71Lys | p.E71K | Q15113 | protein_coding | tolerated(0.08) | benign(0.036) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PCOLCE | SNV | Missense_Mutation | novel | c.113N>C | p.Gly38Ala | p.G38A | Q15113 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PCOLCE | SNV | Missense_Mutation | c.112N>A | p.Gly38Arg | p.G38R | Q15113 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6607-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PCOLCE | SNV | Missense_Mutation | rs780465700 | c.346N>T | p.Arg116Trp | p.R116W | Q15113 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PCOLCE | SNV | Missense_Mutation | rs200657795 | c.1231N>A | p.Val411Ile | p.V411I | Q15113 | protein_coding | tolerated(0.85) | benign(0.003) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCOLCE | SNV | Missense_Mutation | c.115G>T | p.Gly39Trp | p.G39W | Q15113 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCOLCE | deletion | Frame_Shift_Del | c.475delT | p.Cys159AlafsTer12 | p.C159Afs*12 | Q15113 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
PCOLCE | SNV | Missense_Mutation | novel | c.609G>T | p.Glu203Asp | p.E203D | Q15113 | protein_coding | tolerated(0.36) | benign(0.021) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCOLCE | SNV | Missense_Mutation | novel | c.934G>T | p.Ala312Ser | p.A312S | Q15113 | protein_coding | tolerated(0.75) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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