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Gene: PCBP2 |
Gene summary for PCBP2 |
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Gene information | Species | Human | Gene symbol | PCBP2 | Gene ID | 5094 |
Gene name | poly(rC) binding protein 2 | |
Gene Alias | HNRNPE2 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q15366 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5094 | PCBP2 | CA_HPV_1 | Human | Cervix | CC | 3.13e-11 | -5.53e-02 | 0.0264 |
5094 | PCBP2 | CCI_1 | Human | Cervix | CC | 4.91e-02 | -4.02e-01 | 0.528 |
5094 | PCBP2 | CCI_3 | Human | Cervix | CC | 2.16e-04 | -5.07e-01 | 0.516 |
5094 | PCBP2 | CCII_1 | Human | Cervix | CC | 2.18e-07 | -5.20e-01 | 0.3249 |
5094 | PCBP2 | L1 | Human | Cervix | CC | 4.92e-02 | -2.73e-01 | 0.0802 |
5094 | PCBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.31e-03 | -1.91e-01 | 0.0155 |
5094 | PCBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.76e-06 | 4.27e-01 | -0.1954 |
5094 | PCBP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.96e-03 | 3.79e-01 | 0.096 |
5094 | PCBP2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.16e-08 | 9.57e-01 | 0.0171 |
5094 | PCBP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.96e-03 | 4.44e-01 | 0.0674 |
5094 | PCBP2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.04e-11 | 1.53e+00 | 0.3487 |
5094 | PCBP2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.75e-15 | 9.27e-01 | 0.281 |
5094 | PCBP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.59e-05 | 6.63e-01 | 0.3859 |
5094 | PCBP2 | A002-C-010 | Human | Colorectum | FAP | 7.37e-06 | -1.45e-01 | 0.242 |
5094 | PCBP2 | A015-C-203 | Human | Colorectum | FAP | 1.45e-26 | -3.02e-01 | -0.1294 |
5094 | PCBP2 | A015-C-204 | Human | Colorectum | FAP | 3.82e-04 | -1.73e-01 | -0.0228 |
5094 | PCBP2 | A014-C-040 | Human | Colorectum | FAP | 5.56e-03 | -1.80e-01 | -0.1184 |
5094 | PCBP2 | A002-C-201 | Human | Colorectum | FAP | 1.56e-10 | -1.94e-01 | 0.0324 |
5094 | PCBP2 | A001-C-119 | Human | Colorectum | FAP | 3.42e-03 | -2.94e-01 | -0.1557 |
5094 | PCBP2 | A001-C-108 | Human | Colorectum | FAP | 7.48e-17 | -3.43e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019080 | Colorectum | AD | viral gene expression | 42/3918 | 94/18723 | 1.90e-07 | 8.02e-06 | 42 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0075522 | Colorectum | AD | IRES-dependent viral translational initiation | 8/3918 | 11/18723 | 3.26e-04 | 3.85e-03 | 8 |
GO:0019081 | Colorectum | AD | viral translation | 10/3918 | 16/18723 | 3.64e-04 | 4.22e-03 | 10 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00190801 | Colorectum | SER | viral gene expression | 29/2897 | 94/18723 | 1.32e-04 | 2.66e-03 | 29 |
GO:00190791 | Colorectum | SER | viral genome replication | 37/2897 | 131/18723 | 1.36e-04 | 2.72e-03 | 37 |
GO:00755221 | Colorectum | SER | IRES-dependent viral translational initiation | 7/2897 | 11/18723 | 3.91e-04 | 5.91e-03 | 7 |
GO:00190811 | Colorectum | SER | viral translation | 8/2897 | 16/18723 | 1.30e-03 | 1.45e-02 | 8 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
GO:00190582 | Colorectum | MSS | viral life cycle | 111/3467 | 317/18723 | 1.65e-12 | 2.95e-10 | 111 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00190802 | Colorectum | MSS | viral gene expression | 41/3467 | 94/18723 | 1.74e-08 | 9.85e-07 | 41 |
GO:00190792 | Colorectum | MSS | viral genome replication | 49/3467 | 131/18723 | 2.73e-07 | 1.11e-05 | 49 |
GO:00190812 | Colorectum | MSS | viral translation | 10/3467 | 16/18723 | 1.25e-04 | 1.93e-03 | 10 |
GO:00755222 | Colorectum | MSS | IRES-dependent viral translational initiation | 8/3467 | 11/18723 | 1.32e-04 | 2.01e-03 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421614 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa0421615 | Cervix | CC | Ferroptosis | 14/1267 | 41/8465 | 1.75e-03 | 7.21e-03 | 4.26e-03 | 14 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa042162 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042163 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042164 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042165 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa042166 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa042167 | Colorectum | CRC | Ferroptosis | 13/1091 | 41/8465 | 1.36e-03 | 1.08e-02 | 7.33e-03 | 13 |
hsa0421616 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421617 | Endometrium | AEH | Ferroptosis | 15/1197 | 41/8465 | 2.83e-04 | 2.30e-03 | 1.68e-03 | 15 |
hsa0421625 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421635 | Endometrium | EEC | Ferroptosis | 16/1237 | 41/8465 | 1.09e-04 | 1.08e-03 | 8.08e-04 | 16 |
hsa0421628 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa04216111 | Esophagus | HGIN | Ferroptosis | 15/1383 | 41/8465 | 1.35e-03 | 1.26e-02 | 1.00e-02 | 15 |
hsa0421629 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa0421638 | Esophagus | ESCC | Ferroptosis | 33/4205 | 41/8465 | 4.58e-05 | 1.99e-04 | 1.02e-04 | 33 |
hsa042168 | Liver | NAFLD | Ferroptosis | 12/1043 | 41/8465 | 2.98e-03 | 2.96e-02 | 2.39e-02 | 12 |
hsa0421611 | Liver | NAFLD | Ferroptosis | 12/1043 | 41/8465 | 2.98e-03 | 2.96e-02 | 2.39e-02 | 12 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCBP2 | SNV | Missense_Mutation | c.255N>G | p.Ser85Arg | p.S85R | Q15366 | protein_coding | tolerated(0.11) | benign(0.009) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PCBP2 | SNV | Missense_Mutation | novel | c.284N>C | p.Arg95Thr | p.R95T | Q15366 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PCBP2 | SNV | Missense_Mutation | c.58A>G | p.Met20Val | p.M20V | Q15366 | protein_coding | deleterious(0) | possibly_damaging(0.812) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCBP2 | SNV | Missense_Mutation | c.388C>G | p.Gln130Glu | p.Q130E | Q15366 | protein_coding | deleterious(0.02) | benign(0.092) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
PCBP2 | insertion | Frame_Shift_Ins | novel | c.482_483insT | p.Gln161HisfsTer61 | p.Q161Hfs*61 | Q15366 | protein_coding | TCGA-A7-A26H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | ||
PCBP2 | insertion | Frame_Shift_Ins | novel | c.347_348insAGACT | p.Gly117AspfsTer64 | p.G117Dfs*64 | Q15366 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
PCBP2 | insertion | Nonsense_Mutation | novel | c.349_350insACTAGGAAGCTCCACTGA | p.Gly117delinsAspTerGluAlaProLeuArg | p.G117delinsD*EAPLR | Q15366 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
PCBP2 | insertion | Frame_Shift_Ins | rs776329515 | c.517_518insC | p.Lys176GlufsTer46 | p.K176Efs*46 | Q15366 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
PCBP2 | insertion | Frame_Shift_Ins | rs776329515 | c.517_518insC | p.Lys176GlufsTer46 | p.K176Efs*46 | Q15366 | protein_coding | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PCBP2 | SNV | Missense_Mutation | c.524C>T | p.Pro175Leu | p.P175L | Q15366 | protein_coding | deleterious(0.02) | benign(0.036) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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