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Gene: OCIAD1 |
Gene summary for OCIAD1 |
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Gene information | Species | Human | Gene symbol | OCIAD1 | Gene ID | 54940 |
Gene name | OCIA domain containing 1 | |
Gene Alias | ASRIJ | |
Cytomap | 4p11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R9U3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54940 | OCIAD1 | AEH-subject1 | Human | Endometrium | AEH | 3.05e-15 | -3.66e-01 | -0.3059 |
54940 | OCIAD1 | AEH-subject2 | Human | Endometrium | AEH | 5.71e-13 | -3.35e-01 | -0.2525 |
54940 | OCIAD1 | AEH-subject3 | Human | Endometrium | AEH | 1.22e-16 | -3.16e-01 | -0.2576 |
54940 | OCIAD1 | AEH-subject4 | Human | Endometrium | AEH | 1.80e-03 | -2.15e-01 | -0.2657 |
54940 | OCIAD1 | AEH-subject5 | Human | Endometrium | AEH | 1.57e-06 | -2.75e-01 | -0.2953 |
54940 | OCIAD1 | EEC-subject1 | Human | Endometrium | EEC | 1.70e-14 | -3.07e-01 | -0.2682 |
54940 | OCIAD1 | EEC-subject2 | Human | Endometrium | EEC | 4.65e-20 | -4.42e-01 | -0.2607 |
54940 | OCIAD1 | EEC-subject3 | Human | Endometrium | EEC | 1.59e-45 | -4.98e-01 | -0.2525 |
54940 | OCIAD1 | EEC-subject4 | Human | Endometrium | EEC | 2.10e-07 | -2.30e-01 | -0.2571 |
54940 | OCIAD1 | EEC-subject5 | Human | Endometrium | EEC | 1.01e-04 | -1.74e-01 | -0.249 |
54940 | OCIAD1 | GSM5276934 | Human | Endometrium | EEC | 7.72e-03 | -1.62e-02 | -0.0913 |
54940 | OCIAD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.29e-37 | -4.55e-01 | -0.1869 |
54940 | OCIAD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.32e-39 | -3.04e-01 | -0.1875 |
54940 | OCIAD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.60e-38 | -4.30e-01 | -0.1883 |
54940 | OCIAD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.45e-36 | -2.57e-01 | -0.1934 |
54940 | OCIAD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.90e-58 | -3.43e-01 | -0.1917 |
54940 | OCIAD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.44e-55 | -4.56e-01 | -0.1916 |
54940 | OCIAD1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.53e-07 | -8.86e-02 | -0.1269 |
54940 | OCIAD1 | LZE4T | Human | Esophagus | ESCC | 2.20e-15 | 6.46e-01 | 0.0811 |
54940 | OCIAD1 | LZE5T | Human | Esophagus | ESCC | 4.29e-07 | 6.97e-02 | 0.0514 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200073613 | Oral cavity | LP | regulation of stem cell differentiation | 24/4623 | 58/18723 | 3.78e-03 | 2.48e-02 | 24 |
GO:004887226 | Oral cavity | EOLP | homeostasis of number of cells | 68/2218 | 272/18723 | 1.20e-09 | 8.27e-08 | 68 |
GO:004887233 | Oral cavity | NEOLP | homeostasis of number of cells | 65/2005 | 272/18723 | 3.20e-10 | 2.93e-08 | 65 |
GO:200073621 | Oral cavity | NEOLP | regulation of stem cell differentiation | 17/2005 | 58/18723 | 8.04e-05 | 1.01e-03 | 17 |
GO:004886316 | Oral cavity | NEOLP | stem cell differentiation | 38/2005 | 206/18723 | 5.82e-04 | 5.05e-03 | 38 |
GO:004887218 | Prostate | BPH | homeostasis of number of cells | 79/3107 | 272/18723 | 1.79e-07 | 3.99e-06 | 79 |
GO:00488636 | Prostate | BPH | stem cell differentiation | 55/3107 | 206/18723 | 1.56e-04 | 1.36e-03 | 55 |
GO:20007363 | Prostate | BPH | regulation of stem cell differentiation | 21/3107 | 58/18723 | 2.44e-04 | 1.94e-03 | 21 |
GO:004887219 | Prostate | Tumor | homeostasis of number of cells | 86/3246 | 272/18723 | 5.29e-09 | 2.11e-07 | 86 |
GO:200073612 | Prostate | Tumor | regulation of stem cell differentiation | 21/3246 | 58/18723 | 4.52e-04 | 3.42e-03 | 21 |
GO:004886315 | Prostate | Tumor | stem cell differentiation | 55/3246 | 206/18723 | 4.81e-04 | 3.57e-03 | 55 |
GO:004887229 | Skin | cSCC | homeostasis of number of cells | 104/4864 | 272/18723 | 5.34e-06 | 7.71e-05 | 104 |
GO:200073615 | Skin | cSCC | regulation of stem cell differentiation | 31/4864 | 58/18723 | 7.55e-06 | 1.04e-04 | 31 |
GO:004886317 | Skin | cSCC | stem cell differentiation | 69/4864 | 206/18723 | 9.56e-03 | 4.30e-02 | 69 |
GO:004887230 | Thyroid | HT | homeostasis of number of cells | 38/1272 | 272/18723 | 1.82e-05 | 4.31e-04 | 38 |
GO:0061484 | Thyroid | HT | hematopoietic stem cell homeostasis | 5/1272 | 18/18723 | 5.83e-03 | 3.74e-02 | 5 |
GO:004886310 | Thyroid | HT | stem cell differentiation | 24/1272 | 206/18723 | 6.84e-03 | 4.19e-02 | 24 |
GO:0048872113 | Thyroid | PTC | homeostasis of number of cells | 125/5968 | 272/18723 | 7.25e-07 | 1.14e-05 | 125 |
GO:20007367 | Thyroid | PTC | regulation of stem cell differentiation | 32/5968 | 58/18723 | 2.01e-04 | 1.50e-03 | 32 |
GO:004886318 | Thyroid | PTC | stem cell differentiation | 85/5968 | 206/18723 | 2.71e-03 | 1.36e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OCIAD1 | SNV | Missense_Mutation | c.683N>C | p.Arg228Thr | p.R228T | Q9NX40 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
OCIAD1 | SNV | Missense_Mutation | c.565G>C | p.Glu189Gln | p.E189Q | Q9NX40 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
OCIAD1 | SNV | Missense_Mutation | c.622N>C | p.Glu208Gln | p.E208Q | Q9NX40 | protein_coding | tolerated(0.07) | benign(0.074) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
OCIAD1 | SNV | Missense_Mutation | novel | c.465N>A | p.Met155Ile | p.M155I | Q9NX40 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
OCIAD1 | SNV | Missense_Mutation | c.494N>A | p.Ser165Asn | p.S165N | Q9NX40 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OCIAD1 | SNV | Missense_Mutation | c.61A>G | p.Ile21Val | p.I21V | Q9NX40 | protein_coding | tolerated(0.46) | benign(0.191) | TCGA-AD-6890-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OCIAD1 | SNV | Missense_Mutation | novel | c.535N>G | p.His179Asp | p.H179D | Q9NX40 | protein_coding | tolerated(0.46) | benign(0.003) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OCIAD1 | SNV | Missense_Mutation | novel | c.310N>C | p.Lys104Gln | p.K104Q | Q9NX40 | protein_coding | tolerated(0.15) | benign(0.196) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
OCIAD1 | deletion | Frame_Shift_Del | c.690delN | p.Glu233LysfsTer4 | p.E233Kfs*4 | Q9NX40 | protein_coding | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |||
OCIAD1 | deletion | Frame_Shift_Del | c.696delA | p.Glu233LysfsTer4 | p.E233Kfs*4 | Q9NX40 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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