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Gene: OARD1 |
Gene summary for OARD1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | OARD1 | Gene ID | 221443 |
Gene name | O-acyl-ADP-ribose deacylase 1 | |
Gene Alias | C6orf130 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCY9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221443 | OARD1 | LZE2T | Human | Esophagus | ESCC | 8.69e-04 | 1.18e+00 | 0.082 |
221443 | OARD1 | LZE3D | Human | Esophagus | HGIN | 1.69e-04 | 5.48e-01 | 0.0668 |
221443 | OARD1 | LZE4T | Human | Esophagus | ESCC | 6.11e-04 | 1.02e-01 | 0.0811 |
221443 | OARD1 | LZE7T | Human | Esophagus | ESCC | 1.73e-09 | 3.00e-01 | 0.0667 |
221443 | OARD1 | LZE8T | Human | Esophagus | ESCC | 4.25e-05 | 7.03e-02 | 0.067 |
221443 | OARD1 | LZE20T | Human | Esophagus | ESCC | 2.47e-04 | 1.41e-01 | 0.0662 |
221443 | OARD1 | LZE24T | Human | Esophagus | ESCC | 3.13e-15 | 4.63e-01 | 0.0596 |
221443 | OARD1 | LZE21T | Human | Esophagus | ESCC | 2.02e-06 | 2.78e-01 | 0.0655 |
221443 | OARD1 | LZE6T | Human | Esophagus | ESCC | 6.19e-06 | 1.95e-01 | 0.0845 |
221443 | OARD1 | P1T-E | Human | Esophagus | ESCC | 7.24e-08 | 3.17e-01 | 0.0875 |
221443 | OARD1 | P2T-E | Human | Esophagus | ESCC | 3.71e-25 | 4.49e-01 | 0.1177 |
221443 | OARD1 | P4T-E | Human | Esophagus | ESCC | 4.07e-24 | 6.77e-01 | 0.1323 |
221443 | OARD1 | P5T-E | Human | Esophagus | ESCC | 8.85e-19 | 1.87e-01 | 0.1327 |
221443 | OARD1 | P8T-E | Human | Esophagus | ESCC | 8.26e-18 | 3.76e-01 | 0.0889 |
221443 | OARD1 | P9T-E | Human | Esophagus | ESCC | 2.27e-20 | 1.96e-01 | 0.1131 |
221443 | OARD1 | P10T-E | Human | Esophagus | ESCC | 1.39e-20 | 3.50e-01 | 0.116 |
221443 | OARD1 | P11T-E | Human | Esophagus | ESCC | 1.15e-12 | 3.72e-01 | 0.1426 |
221443 | OARD1 | P12T-E | Human | Esophagus | ESCC | 9.51e-29 | 5.19e-01 | 0.1122 |
221443 | OARD1 | P15T-E | Human | Esophagus | ESCC | 5.48e-13 | 2.80e-01 | 0.1149 |
221443 | OARD1 | P16T-E | Human | Esophagus | ESCC | 5.34e-29 | 7.48e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:007252128 | Thyroid | ATC | purine-containing compound metabolic process | 189/6293 | 416/18723 | 2.83e-07 | 4.29e-06 | 189 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OARD1 | SNV | Missense_Mutation | rs770268622 | c.263C>T | p.Ser88Leu | p.S88L | Q9Y530 | protein_coding | tolerated(0.64) | benign(0.214) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | rs770268622 | c.263N>T | p.Ser88Leu | p.S88L | Q9Y530 | protein_coding | tolerated(0.64) | benign(0.214) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | rs769331533 | c.376N>T | p.Arg126Cys | p.R126C | Q9Y530 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | rs769331533 | c.376C>T | p.Arg126Cys | p.R126C | Q9Y530 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | novel | c.343N>A | p.Leu115Ile | p.L115I | Q9Y530 | protein_coding | tolerated(0.69) | benign(0.012) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | rs529411165 | c.409N>A | p.Glu137Lys | p.E137K | Q9Y530 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
OARD1 | SNV | Missense_Mutation | c.445N>A | p.Val149Met | p.V149M | Q9Y530 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | |
OARD1 | SNV | Missense_Mutation | novel | c.150N>T | p.Lys50Asn | p.K50N | Q9Y530 | protein_coding | tolerated(0.24) | possibly_damaging(0.779) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | rs529411165 | c.409N>A | p.Glu137Lys | p.E137K | Q9Y530 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
OARD1 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q9Y530 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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